SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4f0u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_D_IMND476_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 4f0u ALLOPHYCOCYANIN,
BETA SUBUNIT
(Synechococcus
elongatus) 		5 / 12 THR B 129
ILE B 169
TYR B 119
ILE B 126
LEU B 115
 CYC  B 201 (-4.2A)
None
None
None
CYC  B 201 ( 4.9A)
 1.01A 1z9hD-4f0uB:
undetectable		 1z9hD-4f0uB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_A_STIA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4f0u ALLOPHYCOCYANIN
ALPHA CHAIN
ALLOPHYCOCYANIN,
BETA SUBUNIT
(Synechococcus
elongatus) 		4 / 6 LEU B  24
VAL A  52
ILE A  44
ARG A  86
 None
None
None
CYC  A 201 (-3.0A)
 0.92A 2hyyA-4f0uB:
undetectable		 2hyyA-4f0uB:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF502_3
(PHOSPHOLIPASE A2)		 4f0u ALLOPHYCOCYANIN
ALPHA CHAIN
ALLOPHYCOCYANIN,
BETA SUBUNIT
(Synechococcus
elongatus) 		5 / 12 VAL A 100
GLY A  98
ILE A 107
PRO A 106
THR B   6
 None
 1.17A 3bjwF-4f0uA:
undetectable		 3bjwF-4f0uA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAT_A_BEZA1000_0
(BENZOATE-COENZYME A
LIGASE)		 4f0u ALLOPHYCOCYANIN
ALPHA CHAIN
(Synechococcus
elongatus) 		4 / 7 ALA A 142
ALA A 162
GLY A 163
ILE A  44
 None
 0.58A 4eatA-4f0uA:
undetectable		 4eatA-4f0uA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_H_D16H301_1
(THYMIDYLATE SYNTHASE)		 4f0u ALLOPHYCOCYANIN
ALPHA CHAIN
ALLOPHYCOCYANIN,
BETA SUBUNIT
(Synechococcus
elongatus) 		5 / 11 SER A   3
ILE B   5
ASP A  35
GLY A  34
PHE A  30
 None
 1.44A 4foxH-4f0uA:
undetectable		 4foxH-4f0uA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_ACTA402_0
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 4f0u ALLOPHYCOCYANIN,
BETA SUBUNIT
(Synechococcus
elongatus) 		3 / 3 LYS B  75
TYR B  76
ARG B  80
 MEN  B  72 (-3.2A)
None
None
 1.34A 4gc9A-4f0uB:
undetectable		 4gc9A-4f0uB:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5)		 4f0u ALLOPHYCOCYANIN,
BETA SUBUNIT
(Synechococcus
elongatus) 		5 / 7 THR B 140
ALA B  40
THR B  43
ALA B  42
THR B  96
 None
 1.26A 4qw0K-4f0uB:
undetectable		 4qw0K-4f0uB:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5)		 4f0u ALLOPHYCOCYANIN,
BETA SUBUNIT
(Synechococcus
elongatus) 		5 / 7 THR B 140
ALA B  40
THR B  43
ALA B  42
THR B  96
 None
 1.26A 4qw0Y-4f0uB:
undetectable		 4qw0Y-4f0uB:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_C_RTLC201_0
(RETINOL-BINDING
PROTEIN 2)		 4f0u ALLOPHYCOCYANIN,
BETA SUBUNIT
(Synechococcus
elongatus) 		5 / 12 ALA B  98
THR B 129
VAL B 130
LEU B 115
LEU B 112
 None
CYC  B 201 (-4.2A)
None
CYC  B 201 ( 4.9A)
None
 1.16A 4qzuC-4f0uB:
undetectable		 4qzuC-4f0uB:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA406_0
(FAD:PROTEIN FMN
TRANSFERASE)		 4f0u ALLOPHYCOCYANIN
ALPHA CHAIN
ALLOPHYCOCYANIN,
BETA SUBUNIT
(Synechococcus
elongatus;
Synechococcus
elongatus) 		4 / 5 SER B  12
ARG A  93
LEU B  19
ASP B  20
 None
 1.45A 4xdtA-4f0uB:
undetectable		 4xdtA-4f0uB:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE1_A_X2NA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4f0u ALLOPHYCOCYANIN
ALPHA CHAIN
ALLOPHYCOCYANIN,
BETA SUBUNIT
(Synechococcus
elongatus) 		4 / 5 VAL A  32
TYR B 165
ILE B 169
THR B 140
 None
 1.33A 4ze1A-4f0uA:
1.4		 4ze1A-4f0uA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_B_AQ4B602_1
(CYTOCHROME P450 1A1)		 4f0u ALLOPHYCOCYANIN
ALPHA CHAIN
(Synechococcus
elongatus) 		4 / 7 SER A 121
GLY A 114
VAL A 169
LEU A 173
 None
 0.74A 6dwnB-4f0uA:
undetectable		 6dwnB-4f0uA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JMJ_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 4f0u ALLOPHYCOCYANIN,
BETA SUBUNIT
(Synechococcus
elongatus) 		4 / 5 GLY B 127
THR B 129
SER B 171
SER B 170
 None
CYC  B 201 (-4.2A)
None
None
 1.12A 6jmjA-4f0uB:
undetectable		 6jmjA-4f0uB:
24.46