SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4f0x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ME7_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 4f0x MALONYL-COA
DECARBOXYLASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 SER A 381
SER A 382
ILE A 444
GLY A 443
 None
 0.77A 1me7A-4f0xA:
undetectable		 1me7A-4f0xA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MIC_A_DVAA6_0
(GRAMICIDIN A)		 4f0x MALONYL-COA
DECARBOXYLASE,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 ALA A 393
VAL A 391
TRP A 384
 None
 0.88A 1micA-4f0xA:
undetectable
1micB-4f0xA:
undetectable		 1micA-4f0xA:
3.27
1micB-4f0xA:
3.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_A_BEZA11_0
(CES1 PROTEIN)		 4f0x MALONYL-COA
DECARBOXYLASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 4 LEU A 406
SER A 329
LEU A 424
LEU A 430
 None
 1.02A 1yajA-4f0xA:
undetectable		 1yajA-4f0xA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q7L_A_TESA155_1
(ANDROGEN RECEPTOR)		 4f0x MALONYL-COA
DECARBOXYLASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 LEU A 157
TRP A 189
MET A 185
VAL A 181
MET A 178
 None
 1.49A 2q7lA-4f0xA:
undetectable		 2q7lA-4f0xA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1010_1
(SERUM ALBUMIN)		 4f0x MALONYL-COA
DECARBOXYLASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 LEU A 328
ILE A 265
HIS A 219
GLY A 443
 None
 0.96A 3b9lA-4f0xA:
undetectable		 3b9lA-4f0xA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ERD_B_DESB800_1
(ESTROGEN RECEPTOR
ALPHA)		 4f0x MALONYL-COA
DECARBOXYLASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 LEU A 379
LEU A 378
MET A 436
LEU A 398
MET A 399
 None
 1.26A 3erdB-4f0xA:
undetectable		 3erdB-4f0xA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_A_CHDA4_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4f0x MALONYL-COA
DECARBOXYLASE,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 LEU A 398
PRO A 397
LEU A 401
 None
 0.52A 3hcrA-4f0xA:
undetectable		 3hcrA-4f0xA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_A_9PLA501_1
(CYTOCHROME P450 2E1)		 4f0x MALONYL-COA
DECARBOXYLASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 PHE A  71
LEU A  88
PHE A 141
LEU A  44
 None
 0.97A 3t3zA-4f0xA:
undetectable		 3t3zA-4f0xA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_B_9PLB501_1
(CYTOCHROME P450 2E1)		 4f0x MALONYL-COA
DECARBOXYLASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 PHE A  71
LEU A  88
PHE A 141
LEU A  44
 None
 0.97A 3t3zB-4f0xA:
undetectable		 3t3zB-4f0xA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_D_9PLD501_1
(CYTOCHROME P450 2E1)		 4f0x MALONYL-COA
DECARBOXYLASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 PHE A  71
LEU A  88
PHE A 141
LEU A  44
 None
 1.01A 3t3zD-4f0xA:
undetectable		 3t3zD-4f0xA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_D_ACTD1113_0
(BLR5658 PROTEIN)		 4f0x MALONYL-COA
DECARBOXYLASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 4 TRP A 384
LEU A 398
LEU A 338
THR A 335
 None
 1.27A 4bboD-4f0xA:
undetectable		 4bboD-4f0xA:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA504_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 4f0x MALONYL-COA
DECARBOXYLASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 GLY A 304
LEU A 307
ILE A 308
ILE A 291
 None
 0.71A 4em2A-4f0xA:
undetectable		 4em2A-4f0xA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KF9_A_ACTA407_0
(GLUTATHIONE
S-TRANSFERASE
PROTEIN)		 4f0x MALONYL-COA
DECARBOXYLASE,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 GLU A 216
ARG A 230
HIS A 254
 None
 0.80A 4kf9A-4f0xA:
1.6		 4kf9A-4f0xA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_A_ADNA501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 4f0x MALONYL-COA
DECARBOXYLASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 GLN A 156
THR A 245
HIS A 242
LEU A 250
 None
 1.40A 4lvcA-4f0xA:
undetectable		 4lvcA-4f0xA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA602_0
(THIOCYANATE
DEHYDROGENASE)		 4f0x MALONYL-COA
DECARBOXYLASE,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 LYS A 146
HIS A 142
HIS A 143
 None
 1.32A 5oexA-4f0xA:
undetectable		 5oexA-4f0xA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_B_CUB602_0
(THIOCYANATE
DEHYDROGENASE)		 4f0x MALONYL-COA
DECARBOXYLASE,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 LYS A 146
HIS A 142
HIS A 143
 None
 1.33A 5oexB-4f0xA:
undetectable		 5oexB-4f0xA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_C_CUC603_0
(THIOCYANATE
DEHYDROGENASE)		 4f0x MALONYL-COA
DECARBOXYLASE,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 LYS A 146
HIS A 142
HIS A 143
 None
 1.31A 5oexC-4f0xA:
undetectable		 5oexC-4f0xA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_D_CUD603_0
(THIOCYANATE
DEHYDROGENASE)		 4f0x MALONYL-COA
DECARBOXYLASE,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 LYS A 146
HIS A 142
HIS A 143
 None
 1.29A 5oexD-4f0xA:
undetectable		 5oexD-4f0xA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ1_G_6ELG501_0
(PROTEIN CEREBLON)		 4f0x MALONYL-COA
DECARBOXYLASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 TRP A 189
PHE A 194
HIS A 143
THR A  60
 None
 1.25A 5yj1G-4f0xA:
undetectable
5yj1Y-4f0xA:
undetectable		 5yj1G-4f0xA:
12.85
5yj1Y-4f0xA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YVN_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 4f0x MALONYL-COA
DECARBOXYLASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 GLU A 302
LEU A 307
LEU A 250
LEU A 195
 None
 1.17A 5yvnA-4f0xA:
3.5		 5yvnA-4f0xA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4f0x MALONYL-COA
DECARBOXYLASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 11 ILE A 331
PRO A 332
PRO A 418
LEU A 406
LEU A 424
 None
 1.38A 6dlzA-4f0xA:
undetectable
6dlzD-4f0xA:
undetectable		 6dlzA-4f0xA:
10.24
6dlzD-4f0xA:
10.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4f0x MALONYL-COA
DECARBOXYLASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 11 ILE A 331
PRO A 332
PRO A 418
LEU A 406
LEU A 424
 None
 1.38A 6dm1A-4f0xA:
undetectable
6dm1D-4f0xA:
undetectable		 6dm1A-4f0xA:
10.24
6dm1D-4f0xA:
10.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NJ9_K_SAMK500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 4f0x MALONYL-COA
DECARBOXYLASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 PRO A 173
GLY A  89
GLY A  96
GLY A  94
VAL A  48
 None
 1.03A 6nj9K-4f0xA:
undetectable		 6nj9K-4f0xA:
21.43