SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4f15'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3A7E_A_SAMA216_1 (CATECHOL O-METHYLTRANSFERASE)	4f15	FAB FRAGMENT, HEAVY CHAIN (Mus musculus)	4 / 6	GLY B 52 GLU B 55 ILE B 50 ASP B 30	None	0.98A	3a7eA-4f15B: undetectable	3a7eA-4f15B: 20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4F93_B_SANB3004_1 (U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 200 KDA HELICASE)	4f15	FAB FRAGMENT, HEAVY CHAIN (Mus musculus)	4 / 8	GLU B 88 GLU B 81 GLY B 15 SER B 16	None	0.92A	4f93B-4f15B: 4.8	4f93B-4f15B: 8.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4M93_B_ACTB303_0 (S25-26 FAB (IGG1K) HEAVY CHAIN S25-26 FAB (IGG1K) LIGHT CHAIN)	4f15	FAB FRAGMENT, HEAVY CHAIN (Mus musculus)	4 / 5	GLY B 25 SER B 24 ALA B 23 PHE B 26	None	0.99A	4m93B-4f15B: 19.9 4m93C-4f15B: 15.0	4m93B-4f15B: 55.11 4m93C-4f15B: 30.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BPY_A_ACTA408_0 (THIOREDOXIN REDUCTASE)	4f15	FAB FRAGMENT, HEAVY CHAIN (Mus musculus)	3 / 3	PRO B 193 SER B 195 SER B 196	None	0.61A	6bpyA-4f15B: undetectable	6bpyA-4f15B: 22.52

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3A7E_A_SAMA216_1","CATECHOL O-METHYLTRANSFERASE","4f15","FAB FRAGMENT, HEAVY CHAIN","Mus musculus",4,"GLY B  52;GLU B  55;ILE B  50;ASP B  30","None","0.98A","3a7eA-4f15B:undetectable","3a7eA-4f15B:20.82"],["4F93_B_SANB3004_1","U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 200 KDA HELICASE","4f15","FAB FRAGMENT, HEAVY CHAIN","Mus musculus",4,"GLU B  88;GLU B  81;GLY B  15;SER B  16","None","0.92A","4f93B-4f15B:4.8","4f93B-4f15B:8.28"],["4M93_B_ACTB303_0","S25-26 FAB (IGG1K) HEAVY CHAIN;S25-26 FAB (IGG1K) LIGHT CHAIN","4f15","FAB FRAGMENT, HEAVY CHAIN","Mus musculus",4,"GLY B  25;SER B  24;ALA B  23;PHE B  26","None","0.99A","4m93B-4f15B:19.9;4m93C-4f15B:15.0","4m93B-4f15B:55.11;4m93C-4f15B:30.33"],["6BPY_A_ACTA408_0","THIOREDOXIN REDUCTASE","4f15","FAB FRAGMENT, HEAVY CHAIN","Mus musculus",3,"PRO B 193;SER B 195;SER B 196","None","0.61A","6bpyA-4f15B:undetectable","6bpyA-4f15B:22.52"]]