SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4f1k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC5_A_NCAA2001_0
(NAD-DEPENDENT
DEACETYLASE)		 4f1k THROMBOSPONDIN
RELATED ANONYMOUS
PROTEIN
(Plasmodium
falciparum) 		4 / 7 SER A  56
ILE A  59
ILE A 190
ASP A 162
 None
 1.00A 1yc5A-4f1kA:
4.5		 1yc5A-4f1kA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_D_SAMD301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4f1k THROMBOSPONDIN
RELATED ANONYMOUS
PROTEIN
(Plasmodium
falciparum) 		3 / 3 ASP A 135
ASP A 170
ASN A  95
 None
None
EDO  A 306 (-4.8A)
 0.78A 2bm9D-4f1kA:
undetectable		 2bm9D-4f1kA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJT_A_SAMA501_1
(N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE)		 4f1k THROMBOSPONDIN
RELATED ANONYMOUS
PROTEIN
(Plasmodium
falciparum) 		3 / 3 ARG A 181
ASP A  48
ASP A  45
 SO4  A 303 (-4.2A)
None
None
 0.75A 2ejtA-4f1kA:
undetectable		 2ejtA-4f1kA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_C_VIAC903_2
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4f1k THROMBOSPONDIN
RELATED ANONYMOUS
PROTEIN
(Plasmodium
falciparum) 		3 / 3 ASN A 125
ILE A  59
MET A  53
 None
 0.85A 2h42C-4f1kA:
undetectable		 2h42C-4f1kA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZQ9_A_CLSA11_1
(BETA-LACTAMASE
TOHO-1)		 4f1k THROMBOSPONDIN
RELATED ANONYMOUS
PROTEIN
(Plasmodium
falciparum) 		4 / 4 GLU A  46
ARG A 150
ASN A 149
ASP A  48
 EDO  A 307 (-3.7A)
EDO  A 307 (-3.9A)
None
None
 1.50A 2zq9A-4f1kA:
undetectable		 2zq9A-4f1kA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_B_CGEB501_1
(CYTOCHROME P450 2B4)		 4f1k THROMBOSPONDIN
RELATED ANONYMOUS
PROTEIN
(Plasmodium
falciparum) 		4 / 8 ILE A 159
PHE A  93
ALA A  97
VAL A 157
 None
 0.70A 3me6B-4f1kA:
undetectable		 3me6B-4f1kA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_D_CGED501_1
(CYTOCHROME P450 2B4)		 4f1k THROMBOSPONDIN
RELATED ANONYMOUS
PROTEIN
(Plasmodium
falciparum) 		5 / 9 ILE A 159
PHE A  93
ALA A  97
VAL A 140
VAL A 157
 None
 1.22A 3me6D-4f1kA:
undetectable		 3me6D-4f1kA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OLS_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 4f1k THROMBOSPONDIN
RELATED ANONYMOUS
PROTEIN
(Plasmodium
falciparum) 		5 / 12 MET A  53
LEU A  51
LEU A  79
ILE A 118
LEU A  71
 None
 1.28A 3olsB-4f1kA:
undetectable		 3olsB-4f1kA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VRM_A_VD3A502_1
(VITAMIN D(3)
25-HYDROXYLASE)		 4f1k THROMBOSPONDIN
RELATED ANONYMOUS
PROTEIN
(Plasmodium
falciparum) 		5 / 12 ILE A  76
LEU A  88
ALA A  90
ILE A 227
LEU A 160
 None
 0.95A 3vrmA-4f1kA:
undetectable		 3vrmA-4f1kA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA301_1
(CHITOSANASE)		 4f1k THROMBOSPONDIN
RELATED ANONYMOUS
PROTEIN
(Plasmodium
falciparum) 		4 / 8 ILE A  59
ASP A 162
GLY A 129
THR A 131
 None
 1.06A 5hwaA-4f1kA:
undetectable		 5hwaA-4f1kA:
22.18