SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4f1n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_A_RBFA98_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 4f1n KPAGO
(Vanderwaltozyma
polyspora) 		5 / 10 LEU A 959
LEU A 958
ILE A 953
PHE A1000
THR A 998
 None
 1.29A 1i18A-4f1nA:
undetectable
1i18B-4f1nA:
undetectable		 1i18A-4f1nA:
6.85
1i18B-4f1nA:
6.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_B_RBFB99_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 4f1n KPAGO
(Vanderwaltozyma
polyspora) 		5 / 10 PHE A1000
THR A 998
LEU A 959
LEU A 958
ILE A 953
 None
 1.29A 1i18A-4f1nA:
undetectable
1i18B-4f1nA:
undetectable		 1i18A-4f1nA:
6.85
1i18B-4f1nA:
6.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P33_A_MTXA351_1
(PTERIDINE REDUCTASE
1)		 4f1n KPAGO
(Vanderwaltozyma
polyspora) 		5 / 12 SER A 870
PHE A 831
LEU A 905
LEU A 880
LEU A 879
 None
 1.37A 1p33A-4f1nA:
undetectable		 1p33A-4f1nA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P91_B_SAMB2401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)		 4f1n KPAGO
(Vanderwaltozyma
polyspora) 		5 / 12 LEU A 398
GLY A 480
GLY A 249
TYR A 402
ILE A 401
 None
 1.07A 1p91B-4f1nA:
undetectable		 1p91B-4f1nA:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XR2_B_C2FB1201_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)		 4f1n KPAGO
(Vanderwaltozyma
polyspora) 		4 / 8 LYS A 432
SER A 336
ARG A 325
GLU A 341
 None
 1.25A 1xr2B-4f1nA:
3.5		 1xr2B-4f1nA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D55_C_DVAC2_0
(ACTINOMYCIN D)		 4f1n KPAGO
(Vanderwaltozyma
polyspora) 		3 / 3 THR A 869
PRO A 871
PRO A 834
 None
 0.65A 2d55C-4f1nA:
undetectable		 2d55C-4f1nA:
1.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D55_C_DVAC8_0
(ACTINOMYCIN D)		 4f1n KPAGO
(Vanderwaltozyma
polyspora) 		3 / 3 PRO A 834
THR A 869
PRO A 871
 None
 0.80A 2d55C-4f1nA:
undetectable		 2d55C-4f1nA:
1.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTJ_B_THRB402_0
(ASPARTOKINASE)		 4f1n KPAGO
(Vanderwaltozyma
polyspora) 		5 / 9 ILE A 786
ILE A 908
GLY A 832
GLU A 873
THR A 909
 None
 1.39A 2dtjA-4f1nA:
undetectable
2dtjB-4f1nA:
undetectable		 2dtjA-4f1nA:
9.85
2dtjB-4f1nA:
9.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6K_A_ADNA699_1
(CHLORINASE)		 4f1n KPAGO
(Vanderwaltozyma
polyspora) 		4 / 7 PHE A1044
TYR A1195
TYR A1196
PRO A1193
 None
A  E   5 ( 4.5A)
None
None
 1.32A 2q6kA-4f1nA:
undetectable		 2q6kA-4f1nA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBM_A_CAMA517_0
(CYTOCHROME P450-CAM)		 4f1n KPAGO
(Vanderwaltozyma
polyspora) 		4 / 8 THR A 333
THR A 423
VAL A 396
ILE A 274
 None
 0.97A 2qbmA-4f1nA:
undetectable		 2qbmA-4f1nA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_A_VD3A701_2
(CYTOCHROME P450 2R1)		 4f1n KPAGO
(Vanderwaltozyma
polyspora) 		3 / 3 MET A 646
VAL A 649
GLU A 661
 None
 0.75A 3c6gA-4f1nA:
undetectable		 3c6gA-4f1nA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKX_B_1UNB201_2
(PROTEASE)		 4f1n KPAGO
(Vanderwaltozyma
polyspora) 		5 / 11 VAL A 729
ILE A1131
ILE A1141
VAL A 237
ILE A 239
 None
 0.99A 3ekxB-4f1nA:
undetectable		 3ekxB-4f1nA:
7.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_B_CHDB924_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4f1n KPAGO
(Vanderwaltozyma
polyspora) 		4 / 7 LEU A1237
ARG A1203
SER A1020
GLY A1002
 None
U  E   1 ( 4.5A)
None
None
 1.03A 3hcrB-4f1nA:
undetectable		 3hcrB-4f1nA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGX_A_SALA102_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 4f1n KPAGO
(Vanderwaltozyma
polyspora) 		4 / 7 VAL A1048
ILE A1015
ILE A1014
GLN A1052
 None
 0.96A 3hgxA-4f1nA:
undetectable		 3hgxA-4f1nA:
8.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_B_DVAB8_0
(GRAMICIDIN D)		 4f1n KPAGO
(Vanderwaltozyma
polyspora) 		3 / 3 VAL A1050
VAL A1048
TRP A1157
 None
 0.90A 3l8lA-4f1nA:
undetectable
3l8lB-4f1nA:
undetectable		 3l8lA-4f1nA:
1.43
3l8lB-4f1nA:
1.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4f1n KPAGO
(Vanderwaltozyma
polyspora) 		4 / 7 TYR A 724
VAL A1096
VAL A 472
ILE A 696
 None
 1.01A 3mssB-4f1nA:
undetectable		 3mssB-4f1nA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHN_A_ACTA108_0
(PROTEIN P-30)		 4f1n KPAGO
(Vanderwaltozyma
polyspora) 		3 / 3 THR A1132
SER A1133
ARG A 227
 None
 0.76A 3phnA-4f1nA:
undetectable		 3phnA-4f1nA:
7.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4f1n KPAGO
(Vanderwaltozyma
polyspora) 		4 / 8 ILE A1041
LEU A 971
VAL A1018
GLY A1019
 None
 0.86A 3w1wA-4f1nA:
3.0		 3w1wA-4f1nA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_A_REAA501_1
(RETINOIC ACID
RECEPTOR BETA)		 4f1n KPAGO
(Vanderwaltozyma
polyspora) 		5 / 11 PHE A 433
LEU A 246
LEU A 483
ILE A 244
PHE A 470
 None
 1.19A 4dm8A-4f1nA:
undetectable		 4dm8A-4f1nA:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K39_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 4f1n KPAGO
(Vanderwaltozyma
polyspora) 		5 / 12 PHE A 392
TYR A 277
ASN A 329
LEU A 428
ILE A 274
 None
 1.32A 4k39A-4f1nA:
undetectable		 4k39A-4f1nA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTJ_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4f1n KPAGO
(Vanderwaltozyma
polyspora) 		3 / 3 ASP A 710
LYS A 270
LEU A 246
 None
 1.06A 4ptjA-4f1nA:
undetectable		 4ptjA-4f1nA:
9.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QN9_B_DXCB610_0
(N-ACYL-PHOSPHATIDYLE
THANOLAMINE-HYDROLYZ
ING PHOSPHOLIPASE D)		 4f1n KPAGO
(Vanderwaltozyma
polyspora) 		3 / 3 GLY A 832
PRO A 833
ALA A1210
 None
 0.36A 4qn9B-4f1nA:
undetectable		 4qn9B-4f1nA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVP_B_GBMB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 4f1n KPAGO
(Vanderwaltozyma
polyspora) 		5 / 12 LEU A1177
VAL A 970
ILE A 968
ASN A 955
LEU A 958
 None
 1.10A 4yvpB-4f1nA:
undetectable		 4yvpB-4f1nA:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 4f1n KPAGO
(Vanderwaltozyma
polyspora) 		4 / 7 LEU A1026
PRO A1038
LEU A1075
TYR A1081
 None
 1.00A 4z4fA-4f1nA:
36.9		 4z4fA-4f1nA:
27.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_C_PAUC602_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 4f1n KPAGO
(Vanderwaltozyma
polyspora) 		4 / 7 GLU A1060
SER A 973
GLY A 972
ALA A1089
 None
 0.87A 5e26C-4f1nA:
undetectable
5e26D-4f1nA:
2.3		 5e26C-4f1nA:
16.06
5e26D-4f1nA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_A_X6XA201_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 4f1n KPAGO
(Vanderwaltozyma
polyspora) 		5 / 9 HIS A 476
TYR A 478
GLY A 479
GLY A 480
VAL A1134
 None
 1.17A 5f8yA-4f1nA:
undetectable		 5f8yA-4f1nA:
9.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_A_X6XA203_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 4f1n KPAGO
(Vanderwaltozyma
polyspora) 		5 / 9 HIS A 476
TYR A 478
GLY A 479
GLY A 480
VAL A1134
 None
 1.14A 5f8yA-4f1nA:
undetectable		 5f8yA-4f1nA:
9.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_B_X6XB202_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 4f1n KPAGO
(Vanderwaltozyma
polyspora) 		5 / 9 HIS A 476
TYR A 478
GLY A 479
GLY A 480
VAL A1134
 None
 1.11A 5f8yB-4f1nA:
undetectable		 5f8yB-4f1nA:
9.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_B_X6XB203_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 4f1n KPAGO
(Vanderwaltozyma
polyspora) 		5 / 9 HIS A 476
TYR A 478
GLY A 479
GLY A 480
VAL A1134
 None
 1.19A 5f8yB-4f1nA:
undetectable		 5f8yB-4f1nA:
9.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_B_TESB502_1
(-)		 4f1n KPAGO
(Vanderwaltozyma
polyspora) 		5 / 12 LEU A 429
LEU A 708
TRP A 269
ILE A 401
ALA A 247
 None
 1.16A 5og9B-4f1nA:
undetectable		 5og9B-4f1nA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB309_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 4f1n KPAGO
(Vanderwaltozyma
polyspora) 		3 / 3 TYR A1160
ALA A 220
TYR A 222
 None
 0.85A 5uunB-4f1nA:
undetectable		 5uunB-4f1nA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW4_A_SAMA302_1
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)		 4f1n KPAGO
(Vanderwaltozyma
polyspora) 		4 / 6 GLU A 511
ARG A 504
ASP A 502
ASP A 517
 None
 1.13A 5zw4A-4f1nA:
undetectable		 5zw4A-4f1nA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_A_9SCA601_0
(SERUM ALBUMIN)		 4f1n KPAGO
(Vanderwaltozyma
polyspora) 		5 / 12 LEU A 515
ILE A 519
GLY A 463
CYH A 522
LEU A 564
 None
 1.23A 6a7pA-4f1nA:
undetectable		 6a7pA-4f1nA:
20.45