SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4f1p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CEO_A_T44A1395_1
(THYROXINE-BINDING
GLOBULIN)		 4f1p ARF-GAP WITH
COILED-COIL, ANK
REPEAT AND PH
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		5 / 11 ALA A 614
LEU A 476
LEU A 472
ASN A 629
LEU A 585
 None
 0.97A 2ceoA-4f1pA:
undetectable		 2ceoA-4f1pA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RIW_A_T44A1395_1
(THYROXINE-BINDING
GLOBULIN)		 4f1p ARF-GAP WITH
COILED-COIL, ANK
REPEAT AND PH
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		5 / 10 ALA A 614
LEU A 476
LEU A 472
ASN A 629
LEU A 585
 None
 0.92A 2riwA-4f1pA:
undetectable
2riwB-4f1pA:
undetectable		 2riwA-4f1pA:
22.52
2riwB-4f1pA:
9.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN6_A_T44A1370_1
(THYROXINE-BINDING
GLOBULIN)		 4f1p ARF-GAP WITH
COILED-COIL, ANK
REPEAT AND PH
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		5 / 10 ALA A 614
LEU A 476
LEU A 472
ASN A 629
LEU A 585
 None
 0.90A 2xn6A-4f1pA:
undetectable
2xn6B-4f1pA:
undetectable		 2xn6A-4f1pA:
23.02
2xn6B-4f1pA:
8.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN7_A_T44A1355_1
(THYROXINE-BINDING
GLOBULIN)		 4f1p ARF-GAP WITH
COILED-COIL, ANK
REPEAT AND PH
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		5 / 10 ALA A 614
LEU A 476
LEU A 472
ASN A 629
LEU A 585
 None
 0.94A 2xn7A-4f1pA:
undetectable
2xn7B-4f1pA:
undetectable		 2xn7A-4f1pA:
22.77
2xn7B-4f1pA:
8.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_B_C2FB4000_0
(DIHYDROPTEROATE
SYNTHASE DHPS)		 4f1p ARF-GAP WITH
COILED-COIL, ANK
REPEAT AND PH
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		5 / 12 ILE A 510
GLY A 436
SER A 432
ASN A 434
ILE A 481
 None
 1.05A 4o1eB-4f1pA:
undetectable		 4o1eB-4f1pA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OT2_A_NPSA601_1
(SERUM ALBUMIN)		 4f1p ARF-GAP WITH
COILED-COIL, ANK
REPEAT AND PH
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU A 450
VAL A 437
GLY A 436
SER A 432
LEU A 439
 None
 1.48A 4ot2A-4f1pA:
undetectable		 4ot2A-4f1pA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UIL_H_QI9H1223_0
(FAB 314.1)		 4f1p ARF-GAP WITH
COILED-COIL, ANK
REPEAT AND PH
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		5 / 12 ALA A 656
GLY A 663
GLY A 667
LEU A 692
PRO A 676
 None
 1.29A 4uilH-4f1pA:
undetectable
4uilL-4f1pA:
undetectable		 4uilH-4f1pA:
19.68
4uilL-4f1pA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DCH_A_ACTA401_0
(SCOE PROTEIN)		 4f1p ARF-GAP WITH
COILED-COIL, ANK
REPEAT AND PH
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		4 / 5 THR A 648
HIS A 645
ASP A 670
ARG A 674
 None
 1.44A 6dchA-4f1pA:
undetectable		 6dchA-4f1pA:
21.61