SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4f1r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IBG_H_OBNH1_1
(IGG2B-KAPPA 40-50
FAB (HEAVY CHAIN))		 4f1r CATABOLITE
REPRESSION CONTROL
PROTEIN
(Pseudomonas
aeruginosa) 		4 / 6 LEU A 257
PHE A  99
TYR A  56
VAL A 102
 None
 1.30A 1ibgH-4f1rA:
undetectable		 1ibgH-4f1rA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XF3_A_J01A500_1
(ORF12)		 4f1r CATABOLITE
REPRESSION CONTROL
PROTEIN
(Pseudomonas
aeruginosa) 		5 / 10 VAL A   8
LEU A 108
ARG A  93
GLY A  92
ALA A  60
 None
 1.18A 2xf3A-4f1rA:
undetectable		 2xf3A-4f1rA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AY0_B_ADNB402_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 4f1r CATABOLITE
REPRESSION CONTROL
PROTEIN
(Pseudomonas
aeruginosa) 		5 / 10 TYR A 145
GLY A 147
ILE A   3
VAL A 251
LEU A 224
 None
 1.19A 3ay0B-4f1rA:
2.2		 3ay0B-4f1rA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWW_A_SFXA801_1
(TRANSPORTER)		 4f1r CATABOLITE
REPRESSION CONTROL
PROTEIN
(Pseudomonas
aeruginosa) 		5 / 12 LEU A  19
GLY A  18
LEU A  20
ILE A  11
PHE A  48
 None
 0.96A 3gwwA-4f1rA:
undetectable		 3gwwA-4f1rA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_A_0LIA1000_2
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 4f1r CATABOLITE
REPRESSION CONTROL
PROTEIN
(Pseudomonas
aeruginosa) 		4 / 5 VAL A 102
ILE A   4
TYR A 145
ILE A  31
 None
 0.87A 4c8bA-4f1rA:
undetectable		 4c8bA-4f1rA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALB_L_TIQL1210_2
(MEDI2452 LIGHT CHAIN)		 4f1r CATABOLITE
REPRESSION CONTROL
PROTEIN
(Pseudomonas
aeruginosa) 		4 / 8 SER A 148
TYR A 150
ALA A  38
GLY A  66
 None
 0.85A 5albL-4f1rA:
undetectable		 5albL-4f1rA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_A_FK5A201_1
(FK506-BINDING
PROTEIN 1)		 4f1r CATABOLITE
REPRESSION CONTROL
PROTEIN
(Pseudomonas
aeruginosa) 		5 / 11 ARG A 141
PHE A  99
VAL A  30
ILE A   3
ILE A  80
 None
 1.16A 5hw8A-4f1rA:
undetectable
5hw8D-4f1rA:
undetectable		 5hw8A-4f1rA:
15.05
5hw8D-4f1rA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_B_RFPB502_2
(RIFAMPIN
MONOOXYGENASE)		 4f1r CATABOLITE
REPRESSION CONTROL
PROTEIN
(Pseudomonas
aeruginosa) 		4 / 6 GLN A  96
VAL A  30
LEU A  83
ARG A  93
 None
 1.33A 6brdB-4f1rA:
undetectable		 6brdB-4f1rA:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKZ_A_SNPA413_0
(AROMATIC
PEROXYGENASE)		 4f1r CATABOLITE
REPRESSION CONTROL
PROTEIN
(Pseudomonas
aeruginosa) 		4 / 7 ASP A 220
GLY A 216
SER A 202
VAL A 158
 None
 0.97A 6ekzA-4f1rA:
undetectable		 6ekzA-4f1rA:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F88_B_STRB502_1
(CYTOCHROME P450
CYP260A1)		 4f1r CATABOLITE
REPRESSION CONTROL
PROTEIN
(Pseudomonas
aeruginosa) 		4 / 6 LEU A  20
ALA A  15
LEU A  55
SER A  47
 None
 0.80A 6f88B-4f1rA:
undetectable		 6f88B-4f1rA:
14.33