SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4f21'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN0_C_T44C601_1
(TRANSTHYRETIN)		 4f21 CARBOXYLESTERASE/PHO
SPHOLIPASE FAMILY
PROTEIN
(Francisella
tularensis) 		5 / 9 LEU A 181
LEU A 185
LEU A 163
GLU A 208
ALA A 138
 None
 1.26A 1sn0A-4f21A:
undetectable
1sn0C-4f21A:
undetectable		 1sn0A-4f21A:
19.67
1sn0C-4f21A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZA_A_FOLA164_0
(DIHYDROFOLATE
REDUCTASE)		 4f21 CARBOXYLESTERASE/PHO
SPHOLIPASE FAMILY
PROTEIN
(Francisella
tularensis) 		5 / 12 ALA A  12
GLU A   7
LEU A   5
ILE A  17
LEU A  96
 None
 1.27A 2zzaA-4f21A:
undetectable		 2zzaA-4f21A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZA_B_FOLB164_0
(DIHYDROFOLATE
REDUCTASE)		 4f21 CARBOXYLESTERASE/PHO
SPHOLIPASE FAMILY
PROTEIN
(Francisella
tularensis) 		5 / 11 ALA A  12
GLU A   7
LEU A   5
ILE A  17
LEU A  96
 None
 1.26A 2zzaB-4f21A:
undetectable		 2zzaB-4f21A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL5_B_1UNB201_1
(PROTEASE)		 4f21 CARBOXYLESTERASE/PHO
SPHOLIPASE FAMILY
PROTEIN
(Francisella
tularensis) 		5 / 10 LEU A 185
ALA A 138
GLY A 118
ILE A 121
PRO A 144
 None
 0.96A 3el5A-4f21A:
undetectable		 3el5A-4f21A:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEG_A_BAXA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 4f21 CARBOXYLESTERASE/PHO
SPHOLIPASE FAMILY
PROTEIN
(Francisella
tularensis) 		4 / 6 VAL A  16
ILE A 212
ILE A 111
LEU A 112
 None
 0.56A 3hegA-4f21A:
undetectable		 3hegA-4f21A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_C_MTXC164_1
(DIHYDROFOLATE
REDUCTASE)		 4f21 CARBOXYLESTERASE/PHO
SPHOLIPASE FAMILY
PROTEIN
(Francisella
tularensis) 		5 / 12 ALA A  12
GLU A   7
LEU A   5
ILE A  17
LEU A  96
 None
 1.25A 3ia4C-4f21A:
undetectable		 3ia4C-4f21A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3P_A_ACTA1223_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15)		 4f21 CARBOXYLESTERASE/PHO
SPHOLIPASE FAMILY
PROTEIN
(Francisella
tularensis) 		4 / 5 ASP A 211
LEU A 163
GLU A 193
LYS A 195
 None
 1.07A 4a3pA-4f21A:
undetectable		 4a3pA-4f21A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZV_A_SAMA1474_0
(WBDD)		 4f21 CARBOXYLESTERASE/PHO
SPHOLIPASE FAMILY
PROTEIN
(Francisella
tularensis) 		5 / 12 GLY A 118
ILE A 121
ILE A 120
LEU A 139
SER A 140
 None
 0.97A 4azvA-4f21A:
2.2		 4azvA-4f21A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_B_NOVB2000_1
(DNA GYRASE SUBUNIT B)		 4f21 CARBOXYLESTERASE/PHO
SPHOLIPASE FAMILY
PROTEIN
(Francisella
tularensis) 		5 / 12 SER A 116
ASP A  25
ILE A  57
PRO A  54
ILE A  86
 None
 1.28A 4uroB-4f21A:
undetectable		 4uroB-4f21A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4f21 CARBOXYLESTERASE/PHO
SPHOLIPASE FAMILY
PROTEIN
(Francisella
tularensis) 		5 / 12 THR A 141
THR A 123
THR A 125
SER A 116
GLY A 118
 None
 1.28A 5l5zV-4f21A:
undetectable
5l5zb-4f21A:
undetectable		 5l5zV-4f21A:
21.17
5l5zb-4f21A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4f21 CARBOXYLESTERASE/PHO
SPHOLIPASE FAMILY
PROTEIN
(Francisella
tularensis) 		5 / 12 THR A 141
THR A 123
THR A 125
SER A 116
GLY A 118
 None
 1.28A 5l5zH-4f21A:
undetectable
5l5zN-4f21A:
undetectable		 5l5zH-4f21A:
21.17
5l5zN-4f21A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_B_BO2B305_1
(PROTEASOME SUBUNIT
BETA TYPE-6)		 4f21 CARBOXYLESTERASE/PHO
SPHOLIPASE FAMILY
PROTEIN
(Francisella
tularensis) 		5 / 12 THR A 141
THR A 123
THR A 125
SER A 116
GLY A 118
 None
 1.29A 5lf3b-4f21A:
undetectable		 5lf3b-4f21A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_N_BO2N304_1
(PROTEASOME SUBUNIT
BETA TYPE-6)		 4f21 CARBOXYLESTERASE/PHO
SPHOLIPASE FAMILY
PROTEIN
(Francisella
tularensis) 		5 / 12 THR A 141
THR A 123
THR A 125
SER A 116
GLY A 118
 None
 1.29A 5lf3N-4f21A:
undetectable		 5lf3N-4f21A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MLM_A_STRA401_1
(-)		 4f21 CARBOXYLESTERASE/PHO
SPHOLIPASE FAMILY
PROTEIN
(Francisella
tularensis) 		5 / 12 PHE A  36
ILE A 216
ALA A  12
ILE A  43
CYH A  15
 None
 1.30A 5mlmA-4f21A:
2.3		 5mlmA-4f21A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UTU_H_ADNH503_2
(ADENOSYLHOMOCYSTEINA
SE)		 4f21 CARBOXYLESTERASE/PHO
SPHOLIPASE FAMILY
PROTEIN
(Francisella
tularensis) 		4 / 5 THR A 219
GLU A 193
HIS A 166
LEU A 139
 None
 1.32A 5utuH-4f21A:
2.6		 5utuH-4f21A:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E5Z_A_CCSA106_0
(PROTEIN/NUCLEIC ACID
DEGLYCASE DJ-1)		 4f21 CARBOXYLESTERASE/PHO
SPHOLIPASE FAMILY
PROTEIN
(Francisella
tularensis) 		5 / 10 GLY A 119
GLY A 114
ILE A 120
ALA A 122
THR A 125
 None
 1.10A 6e5zA-4f21A:
4.1		 6e5zA-4f21A:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_3
(-)		 4f21 CARBOXYLESTERASE/PHO
SPHOLIPASE FAMILY
PROTEIN
(Francisella
tularensis) 		3 / 3 ASP A  51
ASP A  28
ASN A  34
 None
 0.74A 6gngB-4f21A:
5.4		 6gngB-4f21A:
22.75