SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4f2a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FSL_B_NIOB145_1
(LEGHEMOGLOBIN A)		 4f2a CHOLESTERYL ESTER
TRANSFER PROTEIN
(Homo
sapiens) 		4 / 8 PHE A  93
ILE A  64
LEU A 179
VAL A  91
 None
 0.88A 1fslB-4f2aA:
undetectable		 1fslB-4f2aA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOF_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 4f2a CHOLESTERYL ESTER
TRANSFER PROTEIN
(Homo
sapiens) 		4 / 5 GLY A 256
PRO A  18
ALA A  19
ILE A  15
 None
None
None
2OB  A 605 (-3.8A)
 0.87A 2aofA-4f2aA:
undetectable		 2aofA-4f2aA:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X9G_A_LYAA1270_2
(PTERIDINE REDUCTASE)		 4f2a CHOLESTERYL ESTER
TRANSFER PROTEIN
(Homo
sapiens) 		3 / 3 MET A 284
VAL A 427
GLU A 291
 None
 0.89A 2x9gA-4f2aA:
undetectable		 2x9gA-4f2aA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_C_CHDC1265_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4f2a CHOLESTERYL ESTER
TRANSFER PROTEIN
(Homo
sapiens) 		4 / 5 PHE A 463
PHE A 461
LEU A 261
PHE A 263
 2OB  A 605 (-4.6A)
2OB  A 605 (-3.9A)
0SF  A 610 ( 4.3A)
0SF  A 610 ( 4.1A)
 1.22A 2y69C-4f2aA:
undetectable
2y69J-4f2aA:
undetectable		 2y69C-4f2aA:
19.43
2y69J-4f2aA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_P_CHDP1265_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4f2a CHOLESTERYL ESTER
TRANSFER PROTEIN
(Homo
sapiens) 		4 / 5 PHE A 463
PHE A 461
LEU A 261
PHE A 263
 2OB  A 605 (-4.6A)
2OB  A 605 (-3.9A)
0SF  A 610 ( 4.3A)
0SF  A 610 ( 4.1A)
 1.29A 2y69P-4f2aA:
undetectable
2y69W-4f2aA:
undetectable		 2y69P-4f2aA:
19.43
2y69W-4f2aA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4f2a CHOLESTERYL ESTER
TRANSFER PROTEIN
(Homo
sapiens) 		4 / 5 PHE A 463
PHE A 461
LEU A 261
PHE A 263
 2OB  A 605 (-4.6A)
2OB  A 605 (-3.9A)
0SF  A 610 ( 4.3A)
0SF  A 610 ( 4.1A)
 1.24A 3abmC-4f2aA:
undetectable
3abmJ-4f2aA:
undetectable		 3abmC-4f2aA:
19.43
3abmJ-4f2aA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4f2a CHOLESTERYL ESTER
TRANSFER PROTEIN
(Homo
sapiens) 		4 / 5 PHE A 463
PHE A 461
LEU A 261
PHE A 263
 2OB  A 605 (-4.6A)
2OB  A 605 (-3.9A)
0SF  A 610 ( 4.3A)
0SF  A 610 ( 4.1A)
 1.25A 3abmP-4f2aA:
undetectable
3abmW-4f2aA:
undetectable		 3abmP-4f2aA:
19.43
3abmW-4f2aA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4f2a CHOLESTERYL ESTER
TRANSFER PROTEIN
(Homo
sapiens) 		4 / 5 PHE A 463
PHE A 461
LEU A 261
PHE A 263
 2OB  A 605 (-4.6A)
2OB  A 605 (-3.9A)
0SF  A 610 ( 4.3A)
0SF  A 610 ( 4.1A)
 1.25A 3ag3C-4f2aA:
undetectable
3ag3J-4f2aA:
undetectable		 3ag3C-4f2aA:
19.43
3ag3J-4f2aA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_C_CELC682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4f2a CHOLESTERYL ESTER
TRANSFER PROTEIN
(Homo
sapiens) 		4 / 7 SER A  68
LEU A 179
ILE A  31
PHE A  35
 None
 1.07A 3ln1C-4f2aA:
undetectable		 3ln1C-4f2aA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUV_A_ASDA126_1
(STEROID
DELTA-ISOMERASE)		 4f2a CHOLESTERYL ESTER
TRANSFER PROTEIN
(Homo
sapiens) 		5 / 12 PHE A 429
LEU A 455
PHE A 265
VAL A 269
PHE A 236
 2OB  A 606 (-3.5A)
None
PCW  A 607 (-4.4A)
None
PCW  A 607 (-4.5A)
 1.40A 3nuvA-4f2aA:
1.8		 3nuvA-4f2aA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZU_A_X89A411_1
(FLAVOHEMOPROTEIN)		 4f2a CHOLESTERYL ESTER
TRANSFER PROTEIN
(Homo
sapiens) 		5 / 12 ILE A  11
PHE A 263
LEU A 457
ALA A 373
LEU A 380
 0SF  A 610 (-3.2A)
0SF  A 610 ( 4.1A)
2OB  A 606 (-4.5A)
2OB  A 606 ( 3.8A)
None
 0.99A 3ozuA-4f2aA:
undetectable		 3ozuA-4f2aA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R24_A_SAMA302_0
(2'-O-METHYL
TRANSFERASE)		 4f2a CHOLESTERYL ESTER
TRANSFER PROTEIN
(Homo
sapiens) 		5 / 12 SER A 226
GLY A 256
LEU A  21
MET A 260
PHE A 461
 None
None
None
None
2OB  A 605 (-3.9A)
 1.43A 3r24A-4f2aA:
undetectable		 3r24A-4f2aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_B_BEZB1_0
(HEME-BINDING PROTEIN
HUTZ)		 4f2a CHOLESTERYL ESTER
TRANSFER PROTEIN
(Homo
sapiens) 		4 / 6 GLN A 111
TYR A  99
PRO A 160
LEU A 154
 None
None
CL  A 609 (-3.6A)
None
 1.39A 3tgvB-4f2aA:
undetectable		 3tgvB-4f2aA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_D_BEZD1_0
(HEME-BINDING PROTEIN
HUTZ)		 4f2a CHOLESTERYL ESTER
TRANSFER PROTEIN
(Homo
sapiens) 		4 / 6 GLN A 111
TYR A  99
PRO A 160
LEU A 154
 None
None
CL  A 609 (-3.6A)
None
 1.40A 3tgvD-4f2aA:
undetectable		 3tgvD-4f2aA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4f2a CHOLESTERYL ESTER
TRANSFER PROTEIN
(Homo
sapiens) 		4 / 7 ILE A 367
GLU A 365
VAL A 311
PHE A 363
 2OB  A 606 (-4.7A)
None
None
None
 1.07A 4a97H-4f2aA:
undetectable		 4a97H-4f2aA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4f2a CHOLESTERYL ESTER
TRANSFER PROTEIN
(Homo
sapiens) 		4 / 7 ILE A 389
GLU A 365
VAL A 311
PHE A 363
 None
 0.98A 4a97H-4f2aA:
undetectable		 4a97H-4f2aA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FVQ_A_ACTA904_0
(TYROSINE-PROTEIN
KINASE JAK2)		 4f2a CHOLESTERYL ESTER
TRANSFER PROTEIN
(Homo
sapiens) 		3 / 3 PHE A 348
VAL A 346
GLU A 365
 None
2OB  A 606 ( 4.9A)
None
 0.75A 4fvqA-4f2aA:
0.3		 4fvqA-4f2aA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MSD_A_BEZA1202_0
(CARBOXYLIC ACID
REDUCTASE)		 4f2a CHOLESTERYL ESTER
TRANSFER PROTEIN
(Homo
sapiens) 		4 / 5 HIS A 232
ILE A 215
PHE A 263
ALA A 202
 0SF  A 610 (-3.3A)
0SF  A 610 (-3.4A)
0SF  A 610 ( 4.1A)
0SF  A 610 (-2.6A)
 1.18A 5msdA-4f2aA:
undetectable		 5msdA-4f2aA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4f2a CHOLESTERYL ESTER
TRANSFER PROTEIN
(Homo
sapiens) 		4 / 5 PHE A 463
PHE A 461
LEU A 261
PHE A 263
 2OB  A 605 (-4.6A)
2OB  A 605 (-3.9A)
0SF  A 610 ( 4.3A)
0SF  A 610 ( 4.1A)
 1.20A 5wauC-4f2aA:
undetectable
5wauJ-4f2aA:
undetectable		 5wauC-4f2aA:
19.43
5wauJ-4f2aA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_C_CHDC308_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4f2a CHOLESTERYL ESTER
TRANSFER PROTEIN
(Homo
sapiens) 		4 / 5 PHE A 463
PHE A 461
LEU A 261
PHE A 263
 2OB  A 605 (-4.6A)
2OB  A 605 (-3.9A)
0SF  A 610 ( 4.3A)
0SF  A 610 ( 4.1A)
 1.22A 5wauc-4f2aA:
undetectable
5wauj-4f2aA:
undetectable		 5wauc-4f2aA:
19.43
5wauj-4f2aA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_C_CHDC308_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4f2a CHOLESTERYL ESTER
TRANSFER PROTEIN
(Homo
sapiens) 		4 / 5 PHE A 463
PHE A 461
LEU A 261
PHE A 263
 2OB  A 605 (-4.6A)
2OB  A 605 (-3.9A)
0SF  A 610 ( 4.3A)
0SF  A 610 ( 4.1A)
 1.24A 5xdqC-4f2aA:
undetectable
5xdqJ-4f2aA:
undetectable		 5xdqC-4f2aA:
19.43
5xdqJ-4f2aA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4f2a CHOLESTERYL ESTER
TRANSFER PROTEIN
(Homo
sapiens) 		4 / 5 PHE A 463
PHE A 461
LEU A 261
PHE A 263
 2OB  A 605 (-4.6A)
2OB  A 605 (-3.9A)
0SF  A 610 ( 4.3A)
0SF  A 610 ( 4.1A)
 1.25A 5xdqP-4f2aA:
undetectable
5xdqW-4f2aA:
undetectable		 5xdqP-4f2aA:
19.43
5xdqW-4f2aA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9M_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 4f2a CHOLESTERYL ESTER
TRANSFER PROTEIN
(Homo
sapiens) 		4 / 8 LEU A  67
VAL A  91
VAL A  89
ILE A 183
 None
 0.68A 5y9mX-4f2aA:
undetectable		 5y9mX-4f2aA:
9.45