SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4f2g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_B_DVAB8_0
(GRAMICIDIN A)		 4f2g ORNITHINE
CARBAMOYLTRANSFERASE
1
(Burkholderia
thailandensis) 		3 / 3 VAL A 160
VAL A 273
TRP A 245
 None
 0.97A 1bdwA-4f2gA:
undetectable
1bdwB-4f2gA:
undetectable		 1bdwA-4f2gA:
8.00
1bdwB-4f2gA:
8.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CD2_A_FOLA307_0
(DIHYDROFOLATE
REDUCTASE)		 4f2g ORNITHINE
CARBAMOYLTRANSFERASE
1
(Burkholderia
thailandensis) 		5 / 12 ILE A  51
LEU A  10
PHE A 117
ILE A 104
THR A 108
 None
 0.82A 1cd2A-4f2gA:
undetectable		 1cd2A-4f2gA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYR_A_TOPA407_1
(DIHYDROFOLATE
REDUCTASE)		 4f2g ORNITHINE
CARBAMOYLTRANSFERASE
1
(Burkholderia
thailandensis) 		5 / 11 ILE A  51
LEU A  10
PHE A 117
ILE A 104
THR A 108
 None
 0.83A 1dyrA-4f2gA:
undetectable		 1dyrA-4f2gA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BL9_A_CP6A1240_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4f2g ORNITHINE
CARBAMOYLTRANSFERASE
1
(Burkholderia
thailandensis) 		5 / 12 ILE A  51
LEU A  10
PHE A 117
ILE A 104
THR A 108
 None
 0.74A 2bl9A-4f2gA:
undetectable		 2bl9A-4f2gA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_D_SALD5006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4f2g ORNITHINE
CARBAMOYLTRANSFERASE
1
(Burkholderia
thailandensis) 		4 / 5 ARG A 107
PHE A  52
THR A  59
LEU A  61
 PO4  A 402 (-3.0A)
None
PO4  A 402 (-3.8A)
None
 1.43A 2e1qD-4f2gA:
undetectable		 2e1qD-4f2gA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_A_MTXA164_2
(DIHYDROFOLATE
REDUCTASE)		 4f2g ORNITHINE
CARBAMOYLTRANSFERASE
1
(Burkholderia
thailandensis) 		4 / 4 ILE A  51
PHE A 117
ILE A 104
THR A 108
 None
 0.78A 3ia4A-4f2gA:
2.4		 3ia4A-4f2gA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQ8_A_TOPA2001_1
(DIHYDROFOLATE
REDUCTASE)		 4f2g ORNITHINE
CARBAMOYLTRANSFERASE
1
(Burkholderia
thailandensis) 		5 / 9 ILE A  51
LEU A  10
PHE A 117
ILE A 104
THR A 108
 None
 0.81A 3tq8A-4f2gA:
undetectable		 3tq8A-4f2gA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G8Z_X_TOPX301_1
(DIHYDROFOLATE
REDUCTASE)		 4f2g ORNITHINE
CARBAMOYLTRANSFERASE
1
(Burkholderia
thailandensis) 		5 / 10 ILE A  51
LEU A  10
PHE A 117
ILE A 104
THR A 108
 None
 0.80A 4g8zX-4f2gA:
undetectable		 4g8zX-4f2gA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XYZ_A_ACTA103_0
(POLYUBIQUITIN-C)		 4f2g ORNITHINE
CARBAMOYLTRANSFERASE
1
(Burkholderia
thailandensis) 		4 / 4 LEU A 265
ILE A 278
HIS A 263
VAL A 285
 None
 0.86A 4xyzA-4f2gA:
undetectable		 4xyzA-4f2gA:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AGG_Z_AG2Z503_0
(TRNA(ILE2)
2-AGMATINYLCYTIDINE
SYNTHETASE TIAS)		 4f2g ORNITHINE
CARBAMOYLTRANSFERASE
1
(Burkholderia
thailandensis) 		4 / 5 GLU A 119
ASN A 120
VAL A  90
ARG A 116
 None
None
PO4  A 406 (-4.5A)
None
 1.42A 6aggZ-4f2gA:
undetectable		 6aggZ-4f2gA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_A_RFPA502_2
(RIFAMPIN
MONOOXYGENASE)		 4f2g ORNITHINE
CARBAMOYLTRANSFERASE
1
(Burkholderia
thailandensis) 		4 / 4 GLN A 137
VAL A 224
ARG A  60
ARG A 292
 None
None
PO4  A 403 (-3.1A)
PO4  A 402 (-3.0A)
 1.49A 6brdA-4f2gA:
0.8		 6brdA-4f2gA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BTX_A_EDTA503_0
(SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER))		 4f2g ORNITHINE
CARBAMOYLTRANSFERASE
1
(Burkholderia
thailandensis) 		4 / 7 SER A  56
HIS A 134
GLY A 128
ARG A 292
 PO4  A 402 (-2.7A)
PO4  A 402 (-4.0A)
None
PO4  A 402 (-3.0A)
 1.15A 6btxA-4f2gA:
undetectable		 6btxA-4f2gA:
20.93