SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4f2l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2V7B_A_BEZA1529_0 (BENZOATE-COENZYME A LIGASE)	4f2l	5'-AMP-ACTIVATED PROTEIN KINASE CATALYTIC SUBUNIT ALPHA-1 (Rattus norvegicus)	5 / 9	ALA A 321 TYR A 324 ALA A 292 HIS A 325 ILE A 328	None	1.34A	2v7bA-4f2lA: undetectable	2v7bA-4f2lA: 7.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2V7B_B_BEZB1529_0 (BENZOATE-COENZYME A LIGASE)	4f2l	5'-AMP-ACTIVATED PROTEIN KINASE CATALYTIC SUBUNIT ALPHA-1 (Rattus norvegicus)	5 / 9	ALA A 321 TYR A 324 ALA A 292 HIS A 325 ILE A 328	None	1.35A	2v7bB-4f2lA: undetectable	2v7bB-4f2lA: 7.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3AG4_A_CUA517_0 (CYTOCHROME C OXIDASE SUBUNIT 1)	4f2l	5'-AMP-ACTIVATED PROTEIN KINASE CATALYTIC SUBUNIT ALPHA-1 (Rattus norvegicus)	3 / 3	HIS A 339 HIS A 344 HIS A 340	None	0.73A	3ag4A-4f2lA: undetectable	3ag4A-4f2lA: 8.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VLM_F_CVIF301_1 (REGULATORY PROTEIN TETR)	4f2l	5'-AMP-ACTIVATED PROTEIN KINASE CATALYTIC SUBUNIT ALPHA-1 (Rattus norvegicus)	4 / 8	ILE A 328 ARG A 331 VAL A 296 ASP A 290	None	1.17A	5vlmF-4f2lA: undetectable	5vlmF-4f2lA: 15.76

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2V7B_A_BEZA1529_0","BENZOATE-COENZYME A LIGASE","4f2l","5'-AMP-ACTIVATED PROTEIN KINASE CATALYTIC SUBUNIT ALPHA-1","Rattus norvegicus",5,"ALA A 321;TYR A 324;ALA A 292;HIS A 325;ILE A 328","None","1.34A","2v7bA-4f2lA:undetectable","2v7bA-4f2lA:7.54"],["2V7B_B_BEZB1529_0","BENZOATE-COENZYME A LIGASE","4f2l","5'-AMP-ACTIVATED PROTEIN KINASE CATALYTIC SUBUNIT ALPHA-1","Rattus norvegicus",5,"ALA A 321;TYR A 324;ALA A 292;HIS A 325;ILE A 328","None","1.35A","2v7bB-4f2lA:undetectable","2v7bB-4f2lA:7.54"],["3AG4_A_CUA517_0","CYTOCHROME C OXIDASE SUBUNIT 1","4f2l","5'-AMP-ACTIVATED PROTEIN KINASE CATALYTIC SUBUNIT ALPHA-1","Rattus norvegicus",3,"HIS A 339;HIS A 344;HIS A 340","None","0.73A","3ag4A-4f2lA:undetectable","3ag4A-4f2lA:8.47"],["5VLM_F_CVIF301_1","REGULATORY PROTEIN TETR","4f2l","5'-AMP-ACTIVATED PROTEIN KINASE CATALYTIC SUBUNIT ALPHA-1","Rattus norvegicus",4,"ILE A 328;ARG A 331;VAL A 296;ASP A 290","None","1.17A","5vlmF-4f2lA:undetectable","5vlmF-4f2lA:15.76"]]