SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4f2n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_A_QPSA2001_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		 4f2n SUPEROXIDE DISMUTASE
(Leishmania
major) 		4 / 6 TRP A 193
GLY A 177
ASN A 100
PRO A 179
 None
 1.21A 1dedA-4f2nA:
undetectable		 1dedA-4f2nA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EII_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN II)		 4f2n SUPEROXIDE DISMUTASE
(Leishmania
major) 		5 / 12 THR A  90
ALA A  88
LEU A  29
LEU A 180
LEU A  70
 None
 1.31A 1eiiA-4f2nA:
undetectable		 1eiiA-4f2nA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PNL_B_PACB559_0
(PENICILLIN
AMIDOHYDROLASE)		 4f2n SUPEROXIDE DISMUTASE
(Leishmania
major) 		4 / 8 PHE A  99
SER A 174
ALA A 176
ASN A 107
 None
 1.00A 1pnlA-4f2nA:
undetectable
1pnlB-4f2nA:
undetectable		 1pnlA-4f2nA:
18.58
1pnlB-4f2nA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I6X_A_8PRA705_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 4f2n SUPEROXIDE DISMUTASE
(Leishmania
major) 		5 / 10 ALA A 103
ILE A  86
GLY A  91
PHE A  99
GLY A 177
 None
 1.21A 5i6xA-4f2nA:
2.0		 5i6xA-4f2nA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M10_A_NCAA603_0
(CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE)		 4f2n SUPEROXIDE DISMUTASE
(Leishmania
major) 		4 / 5 LEU A 126
PHE A 140
LEU A 168
TRP A 218
 None
 1.34A 5m10A-4f2nA:
undetectable		 5m10A-4f2nA:
18.08