SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4f32'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_1
(HIV-1 PROTEASE)		 4f32 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Burkholderia
vietnamiensis) 		5 / 12 GLY A  97
ALA A  96
VAL A   7
ILE A  10
GLY A  11
 None
 0.76A 1hxbA-4f32A:
undetectable		 1hxbA-4f32A:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PG2_A_ADNA552_1
(METHIONYL-TRNA
SYNTHETASE)		 4f32 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Burkholderia
vietnamiensis) 		5 / 11 ALA A 202
GLY A 198
GLY A 118
ILE A 117
VAL A 113
 None
 0.97A 1pg2A-4f32A:
undetectable		 1pg2A-4f32A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_G_FUAG708_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4f32 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Burkholderia
vietnamiensis) 		5 / 11 THR A 374
SER A 341
SER A 345
LEU A  16
VAL A  23
 None
 1.45A 1q23G-4f32A:
undetectable		 1q23G-4f32A:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R55_A_097A518_1
(ADAM 33)		 4f32 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Burkholderia
vietnamiensis) 		5 / 10 ALA A 246
THR A 343
HIS A 313
HIS A 349
THR A 347
 None
None
N32  A 501 (-4.0A)
N32  A 501 (-3.9A)
None
 1.22A 1r55A-4f32A:
undetectable		 1r55A-4f32A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SA1_B_PODB700_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 4f32 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Burkholderia
vietnamiensis) 		5 / 12 VAL A 412
ALA A 327
ASN A 413
VAL A 310
ALA A 312
 None
 1.16A 1sa1A-4f32A:
undetectable
1sa1B-4f32A:
undetectable		 1sa1A-4f32A:
23.01
1sa1B-4f32A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SA1_D_PODD701_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 4f32 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Burkholderia
vietnamiensis) 		5 / 12 VAL A 412
ALA A 327
ASN A 413
VAL A 310
ALA A 312
 None
 1.15A 1sa1C-4f32A:
undetectable
1sa1D-4f32A:
undetectable		 1sa1C-4f32A:
23.01
1sa1D-4f32A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_A_SAMA301_0
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 4f32 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Burkholderia
vietnamiensis) 		5 / 12 GLY A 197
ALA A 114
VAL A 249
GLU A 251
ALA A  89
 None
 1.36A 1vq1A-4f32A:
undetectable		 1vq1A-4f32A:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X1A_A_SAMA4264_0
(CRTF-RELATED PROTEIN)		 4f32 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Burkholderia
vietnamiensis) 		5 / 12 GLU A 358
HIS A 313
ALA A 414
GLY A 352
GLY A 355
 None
N32  A 501 (-4.0A)
None
CSU  A 172 ( 4.7A)
None
 1.10A 1x1aA-4f32A:
undetectable		 1x1aA-4f32A:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVS_B_MK1B902_1
(POL POLYPROTEIN)		 4f32 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Burkholderia
vietnamiensis) 		5 / 12 GLY A  97
ALA A  96
VAL A   7
ILE A  10
GLY A  11
 None
 0.80A 2avsA-4f32A:
undetectable		 2avsA-4f32A:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GLU_A_SAMA301_0
(YCGJ)		 4f32 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Burkholderia
vietnamiensis) 		5 / 12 GLY A 282
HIS A 278
ALA A 327
ALA A 292
HIS A 313
 N32  A 501 (-4.3A)
N32  A 501 (-4.2A)
None
None
N32  A 501 (-4.0A)
 1.03A 2gluA-4f32A:
undetectable		 2gluA-4f32A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_A_ACTA1117_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 4f32 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Burkholderia
vietnamiensis) 		3 / 3 ASP A 237
ARG A 236
ARG A 230
 None
 0.93A 2j9dA-4f32A:
undetectable
2j9dC-4f32A:
undetectable		 2j9dA-4f32A:
14.58
2j9dC-4f32A:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCN_A_CHDA3_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4f32 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Burkholderia
vietnamiensis) 		4 / 7 LEU A  27
PRO A 231
SER A 229
GLY A 391
 None
 1.09A 3hcnA-4f32A:
2.1		 3hcnA-4f32A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCO_A_CHDA4_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4f32 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Burkholderia
vietnamiensis) 		5 / 9 LEU A  27
PRO A 231
SER A 229
GLY A 391
PRO A 392
 None
 1.21A 3hcoA-4f32A:
1.6		 3hcoA-4f32A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_B_CHDB924_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4f32 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Burkholderia
vietnamiensis) 		4 / 7 LEU A  27
PRO A 231
SER A 229
GLY A 391
 None
 1.03A 3hcrB-4f32A:
undetectable		 3hcrB-4f32A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 4f32 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Burkholderia
vietnamiensis) 		5 / 12 GLY A 197
ALA A  88
ALA A 152
ALA A 353
PRO A 168
 None
 1.07A 3jb3A-4f32A:
undetectable		 3jb3A-4f32A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_B_FLPB701_1
(CYCLOOXYGENASE-2)		 4f32 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Burkholderia
vietnamiensis) 		5 / 11 ARG A 419
LEU A 403
LEU A 366
VAL A 302
GLY A 300
 None
 1.03A 3pghB-4f32A:
undetectable		 3pghB-4f32A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_D_FLPD701_1
(CYCLOOXYGENASE-2)		 4f32 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Burkholderia
vietnamiensis) 		5 / 12 ARG A 419
LEU A 403
LEU A 366
VAL A 302
GLY A 300
 None
 1.02A 3pghD-4f32A:
undetectable		 3pghD-4f32A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QJ7_A_SPMA264_1
(THYMIDYLATE SYNTHASE)		 4f32 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Burkholderia
vietnamiensis) 		4 / 8 ALA A 303
GLN A 306
LEU A 297
ASP A 301
 None
 0.99A 3qj7A-4f32A:
undetectable
3qj7D-4f32A:
undetectable		 3qj7A-4f32A:
20.80
3qj7D-4f32A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_B_AERB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4f32 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Burkholderia
vietnamiensis) 		5 / 12 ALA A 216
PHE A 239
ILE A 117
LEU A 351
GLY A 210
 N32  A 501 ( 4.2A)
N32  A 501 ( 4.3A)
None
CSU  A 172 ( 3.9A)
None
 0.95A 3rukB-4f32A:
undetectable		 3rukB-4f32A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4f32 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Burkholderia
vietnamiensis) 		5 / 12 GLY A  30
GLY A 373
ALA A 394
ALA A 365
ASP A 368
 None
 0.96A 3sudD-4f32A:
undetectable		 3sudD-4f32A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUG_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4f32 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Burkholderia
vietnamiensis) 		5 / 12 GLY A  30
GLY A 373
ALA A 394
ALA A 365
ASP A 368
 None
 0.94A 3sugA-4f32A:
undetectable		 3sugA-4f32A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCB_B_017B202_1
(PROTEASE)		 4f32 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Burkholderia
vietnamiensis) 		4 / 7 PRO A 144
MET A  78
GLY A 122
PRO A 121
 None
 1.35A 3ucbB-4f32A:
undetectable		 3ucbB-4f32A:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_D_UEGD300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4f32 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Burkholderia
vietnamiensis) 		5 / 10 GLY A 288
ASP A 285
GLY A 286
MET A 290
VAL A 331
 None
 1.40A 4c5nD-4f32A:
undetectable		 4c5nD-4f32A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4f32 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Burkholderia
vietnamiensis) 		4 / 8 LEU A  27
PRO A 231
SER A 229
GLY A 391
 None
 1.00A 4klrB-4f32A:
undetectable		 4klrB-4f32A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4f32 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Burkholderia
vietnamiensis) 		4 / 8 PRO A 231
SER A 342
VAL A 319
GLY A 320
 None
None
N32  A 501 (-3.7A)
N32  A 501 (-3.3A)
 0.98A 4klrB-4f32A:
undetectable		 4klrB-4f32A:
22.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LS7_A_1X9A504_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)		 4f32 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Burkholderia
vietnamiensis) 		10 / 12 GLY A 116
ALA A 171
GLU A 200
PHE A 211
HIS A 313
THR A 315
HIS A 349
LEU A 351
GLY A 408
PHE A 409
 None
CSU  A 172 ( 2.7A)
None
None
N32  A 501 (-4.0A)
N32  A 501 (-3.4A)
N32  A 501 (-3.9A)
CSU  A 172 ( 3.9A)
CSU  A 172 (-3.2A)
CSU  A 172 ( 4.0A)
 0.33A 4ls7A-4f32A:
65.7		 4ls7A-4f32A:
48.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LS7_B_1X9B503_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)		 4f32 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Burkholderia
vietnamiensis) 		8 / 12 ALA A 171
PHE A 211
HIS A 313
THR A 315
HIS A 349
LEU A 351
GLY A 408
PHE A 409
 CSU  A 172 ( 2.7A)
None
N32  A 501 (-4.0A)
N32  A 501 (-3.4A)
N32  A 501 (-3.9A)
CSU  A 172 ( 3.9A)
CSU  A 172 (-3.2A)
CSU  A 172 ( 4.0A)
 0.28A 4ls7A-4f32A:
65.7
4ls7B-4f32A:
65.4		 4ls7A-4f32A:
48.10
4ls7B-4f32A:
48.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LS7_B_1X9B503_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)		 4f32 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Burkholderia
vietnamiensis) 		6 / 12 ILE A 117
ALA A 171
HIS A 313
HIS A 349
GLY A 408
PHE A 409
 None
CSU  A 172 ( 2.7A)
N32  A 501 (-4.0A)
N32  A 501 (-3.9A)
CSU  A 172 (-3.2A)
CSU  A 172 ( 4.0A)
 0.64A 4ls7A-4f32A:
65.7
4ls7B-4f32A:
65.4		 4ls7A-4f32A:
48.10
4ls7B-4f32A:
48.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_A_377A402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4f32 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Burkholderia
vietnamiensis) 		5 / 9 ALA A 245
ALA A  85
ALA A 151
ALA A 353
SER A 175
 None
 1.20A 4twdA-4f32A:
undetectable
4twdB-4f32A:
undetectable
4twdC-4f32A:
undetectable
4twdD-4f32A:
undetectable
4twdE-4f32A:
undetectable		 4twdA-4f32A:
21.69
4twdB-4f32A:
21.69
4twdC-4f32A:
21.69
4twdD-4f32A:
21.69
4twdE-4f32A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_H_SAMH301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 4f32 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Burkholderia
vietnamiensis) 		4 / 5 THR A 273
GLY A 288
GLU A 324
HIS A 313
 None
None
None
N32  A 501 (-4.0A)
 1.21A 5c0oH-4f32A:
undetectable		 5c0oH-4f32A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IFU_A_GBMA801_1
(PROLINE--TRNA LIGASE)		 4f32 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Burkholderia
vietnamiensis) 		5 / 12 PHE A 203
LEU A  27
GLU A 358
THR A 343
GLY A 348
 None
 1.16A 5ifuA-4f32A:
undetectable		 5ifuA-4f32A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J6H_A_NCAA402_0
(H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN, Q10 ALPHA
CHAIN)		 4f32 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Burkholderia
vietnamiensis) 		3 / 3 PRO A  66
ARG A  68
GLU A  67
 None
 0.97A 5j6hA-4f32A:
undetectable		 5j6hA-4f32A:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB6_B_ADNB401_1
(ADENOSINE KINASE)		 4f32 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Burkholderia
vietnamiensis) 		5 / 12 GLY A 242
ALA A 353
GLY A 352
ALA A 354
ILE A 357
 None
None
CSU  A 172 ( 4.7A)
CSU  A 172 ( 4.7A)
None
 0.93A 5kb6B-4f32A:
undetectable		 5kb6B-4f32A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_E_D16E402_1
(THYMIDYLATE SYNTHASE)		 4f32 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Burkholderia
vietnamiensis) 		4 / 6 PHE A 161
ILE A 155
LEU A 165
GLY A 166
 None
 0.96A 5x5qE-4f32A:
undetectable		 5x5qE-4f32A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FDY_U_DB8U302_1
(-)		 4f32 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Burkholderia
vietnamiensis) 		5 / 9 LEU A  27
PRO A  15
LEU A 350
GLU A 358
ILE A 357
 None
 1.30A 6fdyU-4f32A:
undetectable		 6fdyU-4f32A:
21.12