SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4f36'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_B_BEZB503_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4f36 NUCLEOSIDE
DIPHOSPHATE KINASE
(Trypanosoma
brucei) 		4 / 6 ALA A  47
TYR A  66
ILE A  72
PRO A  42
 None
 1.15A 1oniB-4f36A:
undetectable
1oniC-4f36A:
undetectable		 1oniB-4f36A:
23.31
1oniC-4f36A:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_H_BEZH515_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4f36 NUCLEOSIDE
DIPHOSPHATE KINASE
(Trypanosoma
brucei) 		4 / 6 ALA A  47
TYR A  66
ILE A  72
PRO A  42
 None
 1.11A 1oniH-4f36A:
undetectable
1oniI-4f36A:
undetectable		 1oniH-4f36A:
23.31
1oniI-4f36A:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_A_SAMA300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 4f36 NUCLEOSIDE
DIPHOSPHATE KINASE
(Trypanosoma
brucei) 		5 / 12 GLY A  81
GLY A  79
GLY A  31
GLU A  78
VAL A  83
 None
 1.03A 2oxtA-4f36A:
undetectable		 2oxtA-4f36A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_C_SAMC300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 4f36 NUCLEOSIDE
DIPHOSPHATE KINASE
(Trypanosoma
brucei) 		5 / 12 GLY A  81
GLY A  79
GLY A  31
GLU A  78
VAL A  83
 None
 0.96A 2oxtC-4f36A:
undetectable		 2oxtC-4f36A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_A_BCZA468_1
(NEURAMINIDASE)		 4f36 NUCLEOSIDE
DIPHOSPHATE KINASE
(Trypanosoma
brucei) 		3 / 3 ASP A 120
ARG A  87
ARG A 127
 None
 1.05A 3k37A-4f36A:
undetectable		 3k37A-4f36A:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_W_BEZW801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4f36 NUCLEOSIDE
DIPHOSPHATE KINASE
(Trypanosoma
brucei) 		4 / 5 PHE A  27
ILE A 103
GLY A  86
ILE A  23
 None
 0.78A 5dzkB-4f36A:
undetectable
5dzkI-4f36A:
undetectable
5dzkW-4f36A:
undetectable		 5dzkB-4f36A:
22.27
5dzkI-4f36A:
23.59
5dzkW-4f36A:
4.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 4f36 NUCLEOSIDE
DIPHOSPHATE KINASE
(Trypanosoma
brucei) 		3 / 3 HIS A  50
GLU A 128
TRP A 132
 None
 1.21A 5odiD-4f36A:
undetectable		 5odiD-4f36A:
20.71