SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4f3e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9H_A_RAPA108_1
(FKBP12.6)		 4f3e CASA
(Thermus
thermophilus) 		5 / 12 PHE A 303
GLU A 357
VAL A 341
PHE A 188
ILE A 337
 None
 1.14A 1c9hA-4f3eA:
undetectable		 1c9hA-4f3eA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_A_QPSA2001_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		 4f3e CASA
(Thermus
thermophilus) 		4 / 6 TRP A  77
GLY A  81
ASN A 194
PRO A  83
 None
 1.26A 1dedA-4f3eA:
undetectable		 1dedA-4f3eA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSE_B_EAAB224_1
(GLUTATHIONE
TRANSFERASE)		 4f3e CASA
(Thermus
thermophilus) 		5 / 12 PRO A 185
MET A 277
LEU A 187
ALA A  50
PHE A 163
 None
 1.07A 1gseB-4f3eA:
3.2		 1gseB-4f3eA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_G_SAMG199_0
(METHIONINE REPRESSOR)		 4f3e CASA
(Thermus
thermophilus) 		5 / 10 GLU A 329
GLU A 322
ALA A 321
LEU A 361
GLY A 192
 None
 1.25A 1mjqG-4f3eA:
undetectable
1mjqH-4f3eA:
undetectable		 1mjqG-4f3eA:
11.16
1mjqH-4f3eA:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_A_HSMA401_1
(NITROPHORIN 1)		 4f3e CASA
(Thermus
thermophilus) 		4 / 4 ASP A 112
LEU A 225
LEU A 220
LEU A 222
 None
 1.40A 1u18A-4f3eA:
undetectable		 1u18A-4f3eA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_C_STRC3001_1
(MINERALOCORTICOID
RECEPTOR)		 4f3e CASA
(Thermus
thermophilus) 		5 / 12 LEU A  64
LEU A  60
LEU A  57
ALA A  58
LEU A  91
 None
 1.16A 1ya3C-4f3eA:
undetectable		 1ya3C-4f3eA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		 4f3e CASA
(Thermus
thermophilus) 		4 / 4 LEU A  52
PRO A 213
ILE A  28
LEU A  56
 None
 1.10A 1ya4B-4f3eA:
undetectable		 1ya4B-4f3eA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4f3e CASA
(Thermus
thermophilus) 		4 / 5 GLY A 343
GLN A 344
VAL A  51
SER A  45
 None
 1.17A 1zzuB-4f3eA:
2.1		 1zzuB-4f3eA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2002_1
(SERUM ALBUMIN)		 4f3e CASA
(Thermus
thermophilus) 		5 / 11 ARG A 155
ALA A 154
LEU A   9
GLU A  25
LEU A  55
 None
 1.12A 2bxeB-4f3eA:
3.2		 2bxeB-4f3eA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q7L_A_TESA155_1
(ANDROGEN RECEPTOR)		 4f3e CASA
(Thermus
thermophilus) 		5 / 12 LEU A 482
GLY A 485
GLN A 484
VAL A 399
THR A 468
 None
 1.24A 2q7lA-4f3eA:
undetectable		 2q7lA-4f3eA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_C_ASDC1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 4f3e CASA
(Thermus
thermophilus) 		4 / 8 ILE A  15
LEU A 158
LEU A 157
PHE A   7
 None
 0.84A 2vctC-4f3eA:
2.0		 2vctC-4f3eA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VUF_A_FUAA2002_1
(SERUM ALBUMIN)		 4f3e CASA
(Thermus
thermophilus) 		4 / 9 PHE A 441
ALA A 442
VAL A 444
GLU A 446
 None
 0.86A 2vufA-4f3eA:
2.4		 2vufA-4f3eA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3008_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4f3e CASA
(Thermus
thermophilus) 		4 / 7 GLU A 394
HIS A 390
GLN A 393
ALA A 396
 None
 0.85A 3kp6B-4f3eA:
undetectable		 3kp6B-4f3eA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PP1_A_ACTA590_0
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 4f3e CASA
(Thermus
thermophilus) 		4 / 5 GLU A 394
LEU A 391
GLN A 484
GLY A 485
 None
 1.25A 3pp1A-4f3eA:
undetectable		 3pp1A-4f3eA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_B_9PLB1_1
(CYTOCHROME P450 2A13)		 4f3e CASA
(Thermus
thermophilus) 		4 / 6 PHE A 441
PHE A 440
ALA A 370
THR A 367
 None
 1.16A 3t3sB-4f3eA:
undetectable		 3t3sB-4f3eA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_B_ADNB401_2
(PUTATIVE ADENOSINE
KINASE)		 4f3e CASA
(Thermus
thermophilus) 		4 / 5 LEU A 425
ALA A 461
THR A 468
PHE A 489
 None
 1.35A 3vasB-4f3eA:
undetectable		 3vasB-4f3eA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_A_ACTA803_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4f3e CASA
(Thermus
thermophilus) 		4 / 6 ILE A 354
GLN A 344
VAL A  51
SER A  45
 None
 1.10A 4kcnA-4f3eA:
undetectable		 4kcnA-4f3eA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KUK_A_RBFA201_2
(BLUE-LIGHT
PHOTORECEPTOR)		 4f3e CASA
(Thermus
thermophilus) 		5 / 9 LEU A  32
VAL A  17
ILE A  41
ARG A  40
ILE A  15
 None
 1.11A 4kukA-4f3eA:
undetectable		 4kukA-4f3eA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_B_DM5B602_1
(SERUM ALBUMIN)		 4f3e CASA
(Thermus
thermophilus) 		5 / 9 PRO A 185
VAL A 290
ALA A 279
PHE A 188
PHE A 299
 None
 1.35A 4lb2B-4f3eA:
2.0		 4lb2B-4f3eA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_STRA301_1
(ANCESTRAL STEROID
RECEPTOR 2)		 4f3e CASA
(Thermus
thermophilus) 		5 / 12 LEU A  64
LEU A  60
LEU A  57
ALA A  58
LEU A  91
 None
 1.12A 4ltwA-4f3eA:
undetectable		 4ltwA-4f3eA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 4f3e CASA
(Thermus
thermophilus) 		4 / 5 TYR A 206
PRO A 276
LEU A  57
TYR A 241
 None
 1.48A 4w5qA-4f3eA:
undetectable		 4w5qA-4f3eA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_A_QDNA602_1
(CYTOCHROME P450 2D6)		 4f3e CASA
(Thermus
thermophilus) 		5 / 11 GLY A 485
LEU A 482
GLU A 486
LEU A 388
ALA A 464
 None
 1.14A 4wnuA-4f3eA:
undetectable		 4wnuA-4f3eA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DBY_A_ACTA617_0
(SERUM ALBUMIN)		 4f3e CASA
(Thermus
thermophilus) 		3 / 3 TRP A 300
ARG A 301
LEU A 457
 None
 0.89A 5dbyA-4f3eA:
undetectable		 5dbyA-4f3eA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HHJ_A_GLYA403_0
(RETRON-TYPE REVERSE
TRANSCRIPTASE)		 4f3e CASA
(Thermus
thermophilus) 		4 / 4 LEU A 433
LEU A 384
GLY A 385
GLU A 382
 None
 1.28A 5hhjA-4f3eA:
undetectable		 5hhjA-4f3eA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HKG_A_RAPA201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1B)		 4f3e CASA
(Thermus
thermophilus) 		5 / 12 PHE A 303
GLU A 357
VAL A 341
PHE A 188
ILE A 337
 None
 1.13A 5hkgA-4f3eA:
undetectable		 5hkgA-4f3eA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOX_A_RFPA502_2
(PENTACHLOROPHENOL
4-MONOOXYGENASE)		 4f3e CASA
(Thermus
thermophilus) 		3 / 3 VAL A 174
ARG A 239
PRO A 244
 None
 0.79A 5koxA-4f3eA:
undetectable		 5koxA-4f3eA:
25.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M54_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 4f3e CASA
(Thermus
thermophilus) 		5 / 12 VAL A 278
ASP A 275
ALA A 186
ARG A  54
LEU A  47
 None
 1.36A 5m54B-4f3eA:
undetectable		 5m54B-4f3eA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_A_C2FA3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4f3e CASA
(Thermus
thermophilus) 		3 / 3 ASP A  11
ASN A   8
ASP A  96
 None
 0.71A 5vopA-4f3eA:
undetectable		 5vopA-4f3eA:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_B_C2FB3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4f3e CASA
(Thermus
thermophilus) 		3 / 3 ASP A  11
ASN A   8
ASP A  96
 None
 0.76A 5vopB-4f3eA:
undetectable		 5vopB-4f3eA:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4f3e CASA
(Thermus
thermophilus) 		4 / 5 ARG A 454
PHE A 437
PHE A 440
LEU A 450
 None
 1.35A 5wauC-4f3eA:
3.3
5wauJ-4f3eA:
undetectable		 5wauC-4f3eA:
19.84
5wauJ-4f3eA:
8.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_C_CHDC308_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4f3e CASA
(Thermus
thermophilus) 		4 / 5 ARG A 454
PHE A 437
PHE A 440
LEU A 450
 None
 1.33A 5wauc-4f3eA:
3.3
5wauj-4f3eA:
undetectable		 5wauc-4f3eA:
19.84
5wauj-4f3eA:
8.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA412_0
(UNCHARACTERIZED
PROTEIN KDOO)		 4f3e CASA
(Thermus
thermophilus) 		3 / 3 LYS A 376
ASN A 373
SER A 449
 None
 1.28A 5yw0A-4f3eA:
undetectable		 5yw0A-4f3eA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEC_C_RBTC601_1
(SCAFFOLD PROTEIN D13)		 4f3e CASA
(Thermus
thermophilus) 		5 / 12 VAL A 341
GLU A 382
VAL A 444
PRO A 438
PHE A 441
 None
 1.24A 6becA-4f3eA:
undetectable
6becB-4f3eA:
undetectable
6becC-4f3eA:
undetectable		 6becA-4f3eA:
20.70
6becB-4f3eA:
20.70
6becC-4f3eA:
20.70