SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4f3l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDT_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 4f3l BMAL1B
(Mus
musculus) 		5 / 11 SER B 418
TYR B 404
TYR B 374
SER B 372
PHE B 350
 None
 1.38A 1fdtA-4f3lB:
undetectable		 1fdtA-4f3lB:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE4_B_T44B328_1
(TRANSTHYRETIN)		 4f3l BMAL1B
CIRCADIAN LOCOMOTER
OUTPUT CYCLES
PROTEIN KAPUT
(Mus
musculus) 		4 / 8 ALA A 117
LEU A 115
ALA B 154
THR A 254
 None
 0.93A 1ie4B-4f3lA:
undetectable
1ie4D-4f3lA:
undetectable		 1ie4B-4f3lA:
17.32
1ie4D-4f3lA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW5_A_SAMA401_1
(MODIFICATION
METHYLASE RSRI)		 4f3l CIRCADIAN LOCOMOTER
OUTPUT CYCLES
PROTEIN KAPUT
BMAL1B
(Mus
musculus;
Mus
musculus) 		3 / 3 ASP B 156
HIS B 321
ASP A 119
 None
 0.86A 1nw5A-4f3lB:
undetectable		 1nw5A-4f3lB:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_B_TRPB603_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4f3l CIRCADIAN LOCOMOTER
OUTPUT CYCLES
PROTEIN KAPUT
(Mus
musculus) 		5 / 12 TYR A 299
GLY A 306
THR A 307
ILE A 297
PHE A 341
 None
 1.32A 2azxB-4f3lA:
undetectable		 2azxB-4f3lA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_F_SAMF301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4f3l CIRCADIAN LOCOMOTER
OUTPUT CYCLES
PROTEIN KAPUT
BMAL1B
(Mus
musculus;
Mus
musculus) 		3 / 3 LYS B 398
ASP A 317
CYH A 337
 None
 0.97A 2br4F-4f3lB:
undetectable		 2br4F-4f3lB:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CDQ_A_SAMA1500_0
(ASPARTOKINASE)		 4f3l CIRCADIAN LOCOMOTER
OUTPUT CYCLES
PROTEIN KAPUT
(Mus
musculus) 		4 / 8 ILE A 125
SER A 130
ASP A 128
LEU A 170
 None
 0.95A 2cdqA-4f3lA:
undetectable		 2cdqA-4f3lA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_B_GLYB502_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4f3l BMAL1B
(Mus
musculus) 		4 / 8 TYR B 404
SER B 418
HIS B 344
SER B 342
 None
 1.34A 2vmyA-4f3lB:
undetectable
2vmyB-4f3lB:
undetectable		 2vmyA-4f3lB:
22.30
2vmyB-4f3lB:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_G_CPFG1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 4f3l BMAL1B
(Mus
musculus) 		3 / 3 ARG B 244
GLY B 242
SER B 312
 None
 0.59A 2xctB-4f3lB:
undetectable		 2xctB-4f3lB:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4f3l BMAL1B
(Mus
musculus) 		4 / 5 ILE B 408
TYR B 340
ARG B 356
THR B 439
 None
 1.48A 3abkN-4f3lB:
undetectable
3abkW-4f3lB:
undetectable		 3abkN-4f3lB:
20.64
3abkW-4f3lB:
9.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IIZ_A_SAMA1501_0
(BIOTIN SYNTHETASE,
PUTATIVE)		 4f3l CIRCADIAN LOCOMOTER
OUTPUT CYCLES
PROTEIN KAPUT
BMAL1B
(Mus
musculus;
Mus
musculus) 		5 / 12 CYH A 195
SER A 153
GLY A 129
ILE B 333
TYR A 210
 None
 1.16A 3iizA-4f3lA:
undetectable		 3iizA-4f3lA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAR_A_ERMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 4f3l BMAL1B
CIRCADIAN LOCOMOTER
OUTPUT CYCLES
PROTEIN KAPUT
(Mus
musculus) 		5 / 12 LEU A 118
ASP A 119
ALA B 359
SER B 246
LEU B 239
 None
 1.29A 4iarA-4f3lA:
undetectable		 4iarA-4f3lA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JXC_A_SAMA402_0
(FEFE-HYDROGENASE
MATURASE)		 4f3l CIRCADIAN LOCOMOTER
OUTPUT CYCLES
PROTEIN KAPUT
BMAL1B
(Mus
musculus;
Mus
musculus) 		5 / 12 CYH A 195
SER A 153
GLY A 129
ILE B 333
TYR A 210
 None
 1.15A 4jxcA-4f3lA:
undetectable		 4jxcA-4f3lA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N16_A_CHDA301_0
(CARBONIC ANHYDRASE 2)		 4f3l CIRCADIAN LOCOMOTER
OUTPUT CYCLES
PROTEIN KAPUT
BMAL1B
(Mus
musculus;
Mus
musculus) 		4 / 8 GLN A 190
HIS B 149
THR A  88
THR A  87
 None
 0.77A 4n16A-4f3lA:
undetectable		 4n16A-4f3lA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_B_SAMB1001_1
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 4f3l CIRCADIAN LOCOMOTER
OUTPUT CYCLES
PROTEIN KAPUT
BMAL1B
(Mus
musculus;
Mus
musculus) 		3 / 3 SER B 211
GLU A 270
GLU A 108
 None
 0.79A 4ymgB-4f3lB:
undetectable		 4ymgB-4f3lB:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FEP_A_SAMA407_0
([FEFE] HYDROGENASE
MATURASE SUBUNIT
HYDE)		 4f3l CIRCADIAN LOCOMOTER
OUTPUT CYCLES
PROTEIN KAPUT
BMAL1B
(Mus
musculus;
Mus
musculus) 		5 / 12 CYH A 195
SER A 153
GLY A 129
ILE B 333
TYR A 210
 None
 1.14A 5fepA-4f3lA:
undetectable		 5fepA-4f3lA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FES_A_SAMA408_0
([FEFE] HYDROGENASE
MATURASE SUBUNIT
HYDE)		 4f3l CIRCADIAN LOCOMOTER
OUTPUT CYCLES
PROTEIN KAPUT
BMAL1B
(Mus
musculus;
Mus
musculus) 		5 / 12 CYH A 195
SER A 153
GLY A 129
ILE B 333
TYR A 210
 None
 1.14A 5fesA-4f3lA:
undetectable		 5fesA-4f3lA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_A_JMSA602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4f3l BMAL1B
CIRCADIAN LOCOMOTER
OUTPUT CYCLES
PROTEIN KAPUT
(Mus
musculus) 		3 / 3 VAL B 162
SER B 284
MET A 114
 None
 0.88A 5ikqA-4f3lB:
undetectable		 5ikqA-4f3lB:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M50_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 4f3l BMAL1B
CIRCADIAN LOCOMOTER
OUTPUT CYCLES
PROTEIN KAPUT
(Mus
musculus) 		5 / 12 ASP B 156
HIS B 321
ARG A 256
GLY A 120
LEU A 141
 None
 1.47A 5m50B-4f3lB:
undetectable		 5m50B-4f3lB:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWV_A_ACAA18_1
(SCRFP-TAG,GP41)		 4f3l BMAL1B
(Mus
musculus) 		5 / 12 LEU B 125
GLY B 127
LEU B 147
GLU B 146
LEU B 142
 None
 1.10A 5nwvA-4f3lB:
undetectable		 5nwvA-4f3lB:
6.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA601_0
(THIOCYANATE
DEHYDROGENASE)		 4f3l CIRCADIAN LOCOMOTER
OUTPUT CYCLES
PROTEIN KAPUT
BMAL1B
(Mus
musculus;
Mus
musculus) 		3 / 3 HIS B 149
ASP B 145
HIS A  84
 None
 0.80A 5oexA-4f3lB:
undetectable		 5oexA-4f3lB:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_B_CUB601_0
(THIOCYANATE
DEHYDROGENASE)		 4f3l CIRCADIAN LOCOMOTER
OUTPUT CYCLES
PROTEIN KAPUT
BMAL1B
(Mus
musculus;
Mus
musculus) 		3 / 3 HIS B 149
ASP B 145
HIS A  84
 None
 0.74A 5oexB-4f3lB:
undetectable		 5oexB-4f3lB:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_C_CUC601_0
(THIOCYANATE
DEHYDROGENASE)		 4f3l CIRCADIAN LOCOMOTER
OUTPUT CYCLES
PROTEIN KAPUT
BMAL1B
(Mus
musculus;
Mus
musculus) 		3 / 3 HIS B 149
ASP B 145
HIS A  84
 None
 0.70A 5oexC-4f3lB:
undetectable		 5oexC-4f3lB:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_D_CUD601_0
(THIOCYANATE
DEHYDROGENASE)		 4f3l CIRCADIAN LOCOMOTER
OUTPUT CYCLES
PROTEIN KAPUT
BMAL1B
(Mus
musculus;
Mus
musculus) 		3 / 3 HIS B 149
ASP B 145
HIS A  84
 None
 0.72A 5oexD-4f3lB:
undetectable		 5oexD-4f3lB:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA307_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 4f3l BMAL1B
CIRCADIAN LOCOMOTER
OUTPUT CYCLES
PROTEIN KAPUT
(Mus
musculus) 		4 / 5 ASP A 317
PRO B 426
GLU B 432
ARG B 343
 None
 1.14A 5uxcA-4f3lA:
undetectable		 5uxcA-4f3lA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_B_ADNB501_1
(-)		 4f3l CIRCADIAN LOCOMOTER
OUTPUT CYCLES
PROTEIN KAPUT
(Mus
musculus) 		5 / 12 LEU A 351
LEU A 321
GLY A 309
HIS A 280
PHE A 276
 None
 1.37A 6gbnB-4f3lA:
undetectable		 6gbnB-4f3lA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HUO_D_08HD501_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT GAMMA-2)		 4f3l BMAL1B
(Mus
musculus) 		4 / 8 PHE B 377
PHE B 350
HIS B 344
SER B 418
 None
 1.22A 6huoC-4f3lB:
undetectable
6huoD-4f3lB:
undetectable		 6huoC-4f3lB:
11.17
6huoD-4f3lB:
11.35