SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4f3m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_A_FLPA1650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 4f3m BH0337 PROTEIN
(Bacillus
halodurans) 		5 / 12 VAL A 144
LEU A   9
GLY A  40
ALA A  42
SER A  44
 None
 0.91A 1cqeA-4f3mA:
undetectable		 1cqeA-4f3mA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_B_FLPB2650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 4f3m BH0337 PROTEIN
(Bacillus
halodurans) 		5 / 12 VAL A 144
LEU A   9
GLY A  40
ALA A  42
SER A  44
 None
 0.92A 1cqeB-4f3mA:
undetectable		 1cqeB-4f3mA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_G_ASDG1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 4f3m BH0337 PROTEIN
(Bacillus
halodurans) 		4 / 7 PHE A   7
LEU A 135
PRO A  33
LEU A  58
 None
 0.81A 2vcvG-4f3mA:
undetectable		 2vcvG-4f3mA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZA_B_FOLB164_0
(DIHYDROFOLATE
REDUCTASE)		 4f3m BH0337 PROTEIN
(Bacillus
halodurans) 		5 / 11 ILE A  55
ALA A  37
LEU A   9
ILE A  45
THR A  34
 None
 1.32A 2zzaB-4f3mA:
undetectable		 2zzaB-4f3mA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B3P_B_H4BB760_1
(NITRIC-OXIDE
SYNTHASE)		 4f3m BH0337 PROTEIN
(Bacillus
halodurans) 		4 / 8 TRP A  47
PHE A  99
GLU A  43
VAL A   5
 None
 1.40A 3b3pA-4f3mA:
undetectable
3b3pB-4f3mA:
undetectable		 3b3pA-4f3mA:
22.17
3b3pB-4f3mA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA800_0
(GLUTAMATE RECEPTOR 2)		 4f3m BH0337 PROTEIN
(Bacillus
halodurans) 		4 / 7 TYR A  46
ASN A 113
ASP A 111
LYS A  48
 None
 1.43A 3lslA-4f3mA:
undetectable
3lslD-4f3mA:
undetectable		 3lslA-4f3mA:
21.58
3lslD-4f3mA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID800_0
(GLUTAMATE RECEPTOR 2)		 4f3m BH0337 PROTEIN
(Bacillus
halodurans) 		4 / 7 TYR A  46
ASN A 113
ASP A 111
LYS A  48
 None
 1.42A 3lslA-4f3mA:
undetectable
3lslD-4f3mA:
undetectable		 3lslA-4f3mA:
21.58
3lslD-4f3mA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_G_PZIG800_0
(GLUTAMATE RECEPTOR 2)		 4f3m BH0337 PROTEIN
(Bacillus
halodurans) 		4 / 6 TYR A  46
ASN A 113
ASP A 111
LYS A  48
 None
 1.42A 3lslG-4f3mA:
undetectable		 3lslG-4f3mA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4f3m BH0337 PROTEIN
(Bacillus
halodurans) 		5 / 12 VAL A 144
LEU A   9
GLY A  40
ALA A  42
SER A  44
 None
 0.94A 5kirA-4f3mA:
undetectable		 5kirA-4f3mA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6L_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4f3m BH0337 PROTEIN
(Bacillus
halodurans) 		5 / 9 ILE A  55
ALA A  37
LEU A   9
ILE A  45
PRO A 146
 None
None
None
None
EDO  A 301 (-4.5A)
 1.49A 5z6lA-4f3mA:
undetectable		 5z6lA-4f3mA:
20.59