SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4f3n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FO4_B_SALB4005_1
(XANTHINE
DEHYDROGENASE)		 4f3n UNCHARACTERIZED ACR,
COG1565 SUPERFAMILY
(Burkholderia
thailandensis) 		4 / 7 GLU A 320
ARG A 238
VAL A 200
ALA A 323
 None
 1.09A 1fo4B-4f3nA:
undetectable		 1fo4B-4f3nA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_B_CCSB47_0
(GLUTATHIONE
S-TRANSFERASE)		 4f3n UNCHARACTERIZED ACR,
COG1565 SUPERFAMILY
(Burkholderia
thailandensis) 		5 / 7 LEU A 103
LEU A 134
GLY A 132
LEU A 129
TYR A 147
 None
 1.37A 1gtiB-4f3nA:
undetectable		 1gtiB-4f3nA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_4
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 4f3n UNCHARACTERIZED ACR,
COG1565 SUPERFAMILY
(Burkholderia
thailandensis) 		4 / 5 LEU A 195
VAL A 260
CYH A 264
ALA A 333
 None
 1.08A 1mz9D-4f3nA:
undetectable		 1mz9D-4f3nA:
7.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 4f3n UNCHARACTERIZED ACR,
COG1565 SUPERFAMILY
(Burkholderia
thailandensis) 		4 / 4 LEU A 195
VAL A 260
CYH A 264
ALA A 333
 None
 0.99A 1mz9E-4f3nA:
undetectable		 1mz9E-4f3nA:
7.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_A_SAMA301_1
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 4f3n UNCHARACTERIZED ACR,
COG1565 SUPERFAMILY
(Burkholderia
thailandensis) 		3 / 3 GLY A 349
ASP A 352
ASN A 347
 None
 0.53A 1vq1A-4f3nA:
10.2		 1vq1A-4f3nA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XPQ_C_SPMC921_1
(FMS1 PROTEIN)		 4f3n UNCHARACTERIZED ACR,
COG1565 SUPERFAMILY
(Burkholderia
thailandensis) 		5 / 11 ASP A 276
LEU A 133
PHE A  99
LEU A 103
TYR A 147
 None
None
EDO  A 503 (-3.5A)
None
None
 1.16A 1xpqC-4f3nA:
0.8		 1xpqC-4f3nA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UVN_A_ECNA1409_1
(CYTOCHROME P450 130)		 4f3n UNCHARACTERIZED ACR,
COG1565 SUPERFAMILY
(Burkholderia
thailandensis) 		5 / 12 LEU A 133
GLY A 187
GLY A 270
THR A 116
LEU A 137
 None
 1.13A 2uvnA-4f3nA:
undetectable		 2uvnA-4f3nA:
25.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_A_P1BA1478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4f3n UNCHARACTERIZED ACR,
COG1565 SUPERFAMILY
(Burkholderia
thailandensis) 		4 / 7 LEU A  43
ILE A  54
ARG A 213
ALA A 204
 None
 0.83A 2xkwA-4f3nA:
undetectable		 2xkwA-4f3nA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA2_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4f3n UNCHARACTERIZED ACR,
COG1565 SUPERFAMILY
(Burkholderia
thailandensis) 		5 / 12 LEU A 267
LEU A 336
LEU A 133
LEU A 144
TYR A 147
 None
 1.39A 3adsA-4f3nA:
undetectable		 3adsA-4f3nA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_B_SAMB301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 4f3n UNCHARACTERIZED ACR,
COG1565 SUPERFAMILY
(Burkholderia
thailandensis) 		5 / 12 GLY A 304
ASP A 305
PHE A 307
ILE A 315
ARG A 213
 None
 1.19A 3iv6B-4f3nA:
11.4		 3iv6B-4f3nA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7V_A_SAMA992_0
(METHYLORNITHINE
SYNTHASE PYLB)		 4f3n UNCHARACTERIZED ACR,
COG1565 SUPERFAMILY
(Burkholderia
thailandensis) 		5 / 12 GLY A 187
GLU A 121
LEU A 129
VAL A 107
ALA A 104
 None
 1.24A 3t7vA-4f3nA:
undetectable		 3t7vA-4f3nA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ECK_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4f3n UNCHARACTERIZED ACR,
COG1565 SUPERFAMILY
(Burkholderia
thailandensis) 		5 / 12 ALA A 108
LEU A 398
PHE A 273
LEU A 267
VAL A 263
 None
 1.17A 4eckA-4f3nA:
undetectable		 4eckA-4f3nA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F3T_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 4f3n UNCHARACTERIZED ACR,
COG1565 SUPERFAMILY
(Burkholderia
thailandensis) 		4 / 4 PHE A 273
VAL A 188
ALA A 272
PHE A 185
 None
 1.41A 4f3tA-4f3nA:
undetectable		 4f3tA-4f3nA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4f3n UNCHARACTERIZED ACR,
COG1565 SUPERFAMILY
(Burkholderia
thailandensis) 		4 / 8 GLU A 283
TYR A 285
GLY A 292
ARG A 289
 None
 1.04A 4fgzA-4f3nA:
12.2
4fgzB-4f3nA:
12.4		 4fgzA-4f3nA:
19.24
4fgzB-4f3nA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_A_SPMA201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4f3n UNCHARACTERIZED ACR,
COG1565 SUPERFAMILY
(Burkholderia
thailandensis) 		4 / 8 ASN A 370
GLU A 380
GLU A  94
TYR A 277
 None
 1.12A 4mj8A-4f3nA:
undetectable
4mj8C-4f3nA:
undetectable		 4mj8A-4f3nA:
15.90
4mj8C-4f3nA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4I_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 4f3n UNCHARACTERIZED ACR,
COG1565 SUPERFAMILY
(Burkholderia
thailandensis) 		3 / 3 VAL A 119
ALA A 148
PHE A 185
 None
 0.93A 4z4iA-4f3nA:
undetectable		 4z4iA-4f3nA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DPD_A_SAMA601_0
(PROTEIN LYSINE
METHYLTRANSFERASE 1)		 4f3n UNCHARACTERIZED ACR,
COG1565 SUPERFAMILY
(Burkholderia
thailandensis) 		5 / 12 GLU A 121
GLY A 123
LEU A 152
SER A 153
VAL A 194
 None
 1.04A 5dpdA-4f3nA:
11.2		 5dpdA-4f3nA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XOO_B_ADNB503_1
(GLYCOSAMINOGLYCAN
XYLOSYLKINASE)		 4f3n UNCHARACTERIZED ACR,
COG1565 SUPERFAMILY
(Burkholderia
thailandensis) 		4 / 5 LEU A 103
VAL A 190
GLU A 121
LEU A 129
 None
 1.10A 5xooB-4f3nA:
undetectable		 5xooB-4f3nA:
9.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_D_SUED1202_0
(NS3 PROTEASE)		 4f3n UNCHARACTERIZED ACR,
COG1565 SUPERFAMILY
(Burkholderia
thailandensis) 		5 / 12 VAL A 257
ILE A 394
PHE A 273
ALA A 272
ALA A 271
 None
 0.98A 6c2mD-4f3nA:
undetectable		 6c2mD-4f3nA:
9.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_A_ACTA204_0
(N-ACETYLTRANSFERASE)		 4f3n UNCHARACTERIZED ACR,
COG1565 SUPERFAMILY
(Burkholderia
thailandensis) 		4 / 5 LEU A 345
THR A 102
THR A 351
GLY A 349
 None
 1.21A 6gtqA-4f3nA:
0.0		 6gtqA-4f3nA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IEY_A_CLMA401_0
(ESTERASE)		 4f3n UNCHARACTERIZED ACR,
COG1565 SUPERFAMILY
(Burkholderia
thailandensis) 		5 / 11 ALA A 113
GLY A 270
SER A 391
PHE A 273
ALA A 389
 None
 1.29A 6ieyA-4f3nA:
undetectable
6ieyB-4f3nA:
undetectable		 6ieyA-4f3nA:
24.83
6ieyB-4f3nA:
24.83