SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4f3v'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		 4f3v ESX-1 SECRETION
SYSTEM PROTEIN ECCA1
(Mycobacterium
tuberculosis) 		4 / 8 SER A  71
SER A   7
ASP A   3
LYS A  -1
 None
 1.19A 1hwiB-4f3vA:
undetectable		 1hwiB-4f3vA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_A_117A2_1
(HMG-COA REDUCTASE)		 4f3v ESX-1 SECRETION
SYSTEM PROTEIN ECCA1
(Mycobacterium
tuberculosis) 		4 / 8 SER A  71
SER A   7
ASP A   3
LYS A  -1
 None
 1.21A 1hwkA-4f3vA:
undetectable		 1hwkA-4f3vA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_C_117C4_1
(HMG-COA REDUCTASE)		 4f3v ESX-1 SECRETION
SYSTEM PROTEIN ECCA1
(Mycobacterium
tuberculosis) 		4 / 8 SER A  71
SER A   7
ASP A   3
LYS A  -1
 None
 1.17A 1hwkC-4f3vA:
undetectable		 1hwkC-4f3vA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_D_117D3_2
(HMG-COA REDUCTASE)		 4f3v ESX-1 SECRETION
SYSTEM PROTEIN ECCA1
(Mycobacterium
tuberculosis) 		4 / 8 SER A  71
SER A   7
ASP A   3
LYS A  -1
 None
 1.17A 1hwkD-4f3vA:
undetectable		 1hwkD-4f3vA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT2_A_SAMA301_0
(FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN)		 4f3v ESX-1 SECRETION
SYSTEM PROTEIN ECCA1
(Mycobacterium
tuberculosis) 		5 / 12 GLY A  43
ALA A  40
THR A  28
ALA A  81
ILE A  45
 None
 1.05A 1nt2A-4f3vA:
undetectable		 1nt2A-4f3vA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JST_A_HLTA101_1
(FOUR-ALPHA-HELIX
BUNDLE)		 4f3v ESX-1 SECRETION
SYSTEM PROTEIN ECCA1
(Mycobacterium
tuberculosis) 		4 / 5 ALA A 170
TRP A 137
LEU A 134
ALA A 171
 None
 1.35A 2jstA-4f3vA:
undetectable
2jstB-4f3vA:
undetectable		 2jstA-4f3vA:
14.29
2jstB-4f3vA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U95_B_MIYB1102_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4f3v ESX-1 SECRETION
SYSTEM PROTEIN ECCA1
(Mycobacterium
tuberculosis) 		5 / 12 SER A 131
PHE A 106
GLY A 105
ILE A 102
ALA A  58
 None
 1.12A 4u95B-4f3vA:
undetectable		 4u95B-4f3vA:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 4f3v ESX-1 SECRETION
SYSTEM PROTEIN ECCA1
(Mycobacterium
tuberculosis) 		4 / 7 PHE A 166
SER A 198
ALA A 171
LEU A 167
 None
 1.11A 4xk8A-4f3vA:
2.5		 4xk8A-4f3vA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_A_SAMA301_0
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 4f3v ESX-1 SECRETION
SYSTEM PROTEIN ECCA1
(Mycobacterium
tuberculosis) 		5 / 12 GLY A  90
ILE A 208
ALA A 170
ASP A  91
ALA A 203
 None
 1.01A 5kvaA-4f3vA:
undetectable		 5kvaA-4f3vA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_B_SAMB301_0
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 4f3v ESX-1 SECRETION
SYSTEM PROTEIN ECCA1
(Mycobacterium
tuberculosis) 		5 / 12 GLY A  90
ILE A 208
ALA A 170
ASP A  91
ALA A 203
 None
 1.00A 5kvaB-4f3vA:
undetectable		 5kvaB-4f3vA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VYH_A_FOLA409_0
(S PROTEIN)		 4f3v ESX-1 SECRETION
SYSTEM PROTEIN ECCA1
(Mycobacterium
tuberculosis) 		5 / 10 TRP A 137
PRO A 163
ALA A 200
GLY A  90
ALA A 171
 None
 1.22A 5vyhA-4f3vA:
undetectable		 5vyhA-4f3vA:
19.94