SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4f40'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_B_FUAB703_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4f40 PROSTAGLANDIN
F2-ALPHA
SYNTHASE/D-ARABINOSE
DEHYDROGENASE
(Leishmania
major) 		3 / 3 VAL A  37
ALA A  36
HIS A 243
 None
 0.69A 1q23C-4f40A:
undetectable		 1q23C-4f40A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_G_FUAG708_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4f40 PROSTAGLANDIN
F2-ALPHA
SYNTHASE/D-ARABINOSE
DEHYDROGENASE
(Leishmania
major) 		3 / 3 VAL A  37
ALA A  36
HIS A 243
 None
 0.75A 1q23H-4f40A:
undetectable		 1q23H-4f40A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_I_FUAI707_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4f40 PROSTAGLANDIN
F2-ALPHA
SYNTHASE/D-ARABINOSE
DEHYDROGENASE
(Leishmania
major) 		3 / 3 VAL A  37
ALA A  36
HIS A 243
 None
 0.71A 1q23G-4f40A:
undetectable		 1q23G-4f40A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_L_FUAL710_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4f40 PROSTAGLANDIN
F2-ALPHA
SYNTHASE/D-ARABINOSE
DEHYDROGENASE
(Leishmania
major) 		3 / 3 VAL A  37
ALA A  36
HIS A 243
 None
 0.75A 1q23J-4f40A:
undetectable		 1q23J-4f40A:
20.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2INE_A_PACA317_0
(ALDOSE REDUCTASE)		 4f40 PROSTAGLANDIN
F2-ALPHA
SYNTHASE/D-ARABINOSE
DEHYDROGENASE
(Leishmania
major) 		4 / 5 TRP A  25
TYR A  54
HIS A 112
TRP A 113
 EDO  A 308 (-4.0A)
EDO  A 308 (-4.4A)
EDO  A 308 (-4.1A)
EDO  A 308 ( 4.3A)
 0.71A 2ineA-4f40A:
38.4		 2ineA-4f40A:
41.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ISF_A_PACA317_0
(ALDOSE REDUCTASE)		 4f40 PROSTAGLANDIN
F2-ALPHA
SYNTHASE/D-ARABINOSE
DEHYDROGENASE
(Leishmania
major) 		4 / 5 TRP A  25
TYR A  54
HIS A 112
TRP A 113
 EDO  A 308 (-4.0A)
EDO  A 308 (-4.4A)
EDO  A 308 (-4.1A)
EDO  A 308 ( 4.3A)
 0.79A 2isfA-4f40A:
38.1		 2isfA-4f40A:
41.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_2
(PROTEASE RETROPEPSIN)		 4f40 PROSTAGLANDIN
F2-ALPHA
SYNTHASE/D-ARABINOSE
DEHYDROGENASE
(Leishmania
major) 		3 / 3 ARG A 144
THR A  10
VAL A  15
 EDO  A 302 ( 4.4A)
EDO  A 303 ( 4.7A)
EDO  A 305 (-3.9A)
 0.98A 2q64A-4f40A:
undetectable		 2q64A-4f40A:
18.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3S3G_A_TLTA317_1
(ALDOSE REDUCTASE)		 4f40 PROSTAGLANDIN
F2-ALPHA
SYNTHASE/D-ARABINOSE
DEHYDROGENASE
(Leishmania
major) 		4 / 7 TRP A  25
TYR A  54
HIS A 112
PHE A 284
 EDO  A 308 (-4.0A)
EDO  A 308 (-4.4A)
EDO  A 308 (-4.1A)
None
 0.92A 3s3gA-4f40A:
38.3		 3s3gA-4f40A:
40.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3S3G_A_TLTA317_1
(ALDOSE REDUCTASE)		 4f40 PROSTAGLANDIN
F2-ALPHA
SYNTHASE/D-ARABINOSE
DEHYDROGENASE
(Leishmania
major) 		4 / 7 TRP A  25
TYR A  54
HIS A 112
TRP A 113
 EDO  A 308 (-4.0A)
EDO  A 308 (-4.4A)
EDO  A 308 (-4.1A)
EDO  A 308 ( 4.3A)
 0.68A 3s3gA-4f40A:
38.3		 3s3gA-4f40A:
40.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_A_ACTA609_0
(GBAA_1210 PROTEIN)		 4f40 PROSTAGLANDIN
F2-ALPHA
SYNTHASE/D-ARABINOSE
DEHYDROGENASE
(Leishmania
major) 		3 / 3 LYS A 240
VAL A 242
HIS A 243
 None
 1.19A 3tj7A-4f40A:
undetectable		 3tj7A-4f40A:
19.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UG8_A_IMNA2001_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 4f40 PROSTAGLANDIN
F2-ALPHA
SYNTHASE/D-ARABINOSE
DEHYDROGENASE
(Leishmania
major) 		5 / 12 TYR A  54
TRP A  81
HIS A 112
ASN A 150
SER A 198
 EDO  A 308 (-4.4A)
None
EDO  A 308 (-4.1A)
EDO  A 308 (-3.4A)
EDO  A 310 (-3.5A)
 0.48A 3ug8A-4f40A:
38.2		 3ug8A-4f40A:
37.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UGR_A_IMNA2001_2
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 4f40 PROSTAGLANDIN
F2-ALPHA
SYNTHASE/D-ARABINOSE
DEHYDROGENASE
(Leishmania
major) 		4 / 7 TYR A  54
ASN A 150
GLU A 173
TYR A 275
 EDO  A 308 (-4.4A)
EDO  A 308 (-3.4A)
None
None
 0.18A 3ugrA-4f40A:
38.1		 3ugrA-4f40A:
37.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3V35_A_NTIA317_1
(ALDOSE REDUCTASE)		 4f40 PROSTAGLANDIN
F2-ALPHA
SYNTHASE/D-ARABINOSE
DEHYDROGENASE
(Leishmania
major) 		4 / 8 TRP A  25
TRP A  81
HIS A 112
PHE A 284
 EDO  A 308 (-4.0A)
None
EDO  A 308 (-4.1A)
None
 1.16A 3v35A-4f40A:
38.8		 3v35A-4f40A:
40.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3V35_A_NTIA317_1
(ALDOSE REDUCTASE)		 4f40 PROSTAGLANDIN
F2-ALPHA
SYNTHASE/D-ARABINOSE
DEHYDROGENASE
(Leishmania
major) 		4 / 8 TRP A  25
TRP A  81
HIS A 112
TRP A 113
 EDO  A 308 (-4.0A)
None
EDO  A 308 (-4.1A)
EDO  A 308 ( 4.3A)
 0.80A 3v35A-4f40A:
38.8		 3v35A-4f40A:
40.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_A_ACTA304_0
(GLUTATHIONE
TRANSFERASE GTE1)		 4f40 PROSTAGLANDIN
F2-ALPHA
SYNTHASE/D-ARABINOSE
DEHYDROGENASE
(Leishmania
major) 		4 / 5 ALA A 196
ILE A 226
LEU A 200
ASN A 230
 None
None
EDO  A 310 (-4.2A)
None
 1.15A 4g19A-4f40A:
undetectable		 4g19A-4f40A:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RFQ_A_SAMA401_1
(HISTIDINE PROTEIN
METHYLTRANSFERASE 1
HOMOLOG)		 4f40 PROSTAGLANDIN
F2-ALPHA
SYNTHASE/D-ARABINOSE
DEHYDROGENASE
(Leishmania
major) 		4 / 4 THR A  33
GLY A  23
ASP A  49
SER A  27
 None
 1.19A 4rfqA-4f40A:
undetectable		 4rfqA-4f40A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECM_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4f40 PROSTAGLANDIN
F2-ALPHA
SYNTHASE/D-ARABINOSE
DEHYDROGENASE
(Leishmania
major) 		4 / 5 THR A  50
ALA A  51
THR A  78
TYR A 109
 None
 1.04A 5ecmA-4f40A:
undetectable		 5ecmA-4f40A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECO_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4f40 PROSTAGLANDIN
F2-ALPHA
SYNTHASE/D-ARABINOSE
DEHYDROGENASE
(Leishmania
major) 		4 / 6 THR A  50
ALA A  51
THR A  78
TYR A 109
 None
 0.98A 5ecoA-4f40A:
2.2		 5ecoA-4f40A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXN_B_SAMB901_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 4f40 PROSTAGLANDIN
F2-ALPHA
SYNTHASE/D-ARABINOSE
DEHYDROGENASE
(Leishmania
major) 		5 / 12 PHE A  75
LEU A  22
GLY A  23
VAL A   9
ILE A 236
 None
 1.25A 6bxnB-4f40A:
undetectable		 6bxnB-4f40A:
20.71