SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4f47'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EA1_A_TPFA470_1
(CYTOCHROME P450
51-LIKE RV0764C)		 4f47 ENOYL-COA HYDRATASE
ECHA19
(Mycobacterium
marinum) 		4 / 8 MET A 190
ARG A 180
THR A 127
LEU A 163
 None
 1.19A 1ea1A-4f47A:
undetectable		 1ea1A-4f47A:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CWK_A_REAA300_1
(CELLULAR RETINOIC
ACID-BINDING PROTEIN
2)		 4f47 ENOYL-COA HYDRATASE
ECHA19
(Mycobacterium
marinum) 		5 / 12 PHE A 144
ALA A 187
ALA A 184
VAL A 197
GLU A 119
 None
 1.26A 3cwkA-4f47A:
undetectable		 3cwkA-4f47A:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4f47 ENOYL-COA HYDRATASE
ECHA19
(Mycobacterium
marinum) 		5 / 12 PHE A  73
MET A  31
VAL A  20
LEU A 130
THR A 133
 None
 1.28A 3elzA-4f47A:
undetectable		 3elzA-4f47A:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FE1_A_PQNA846_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 4f47 ENOYL-COA HYDRATASE
ECHA19
(Mycobacterium
marinum) 		5 / 10 ARG A  33
ALA A  39
LEU A  40
ALA A 187
MET A 190
 None
 1.46A 4fe1A-4f47A:
undetectable
4fe1J-4f47A:
undetectable		 4fe1A-4f47A:
16.27
4fe1J-4f47A:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4f47 ENOYL-COA HYDRATASE
ECHA19
(Mycobacterium
marinum) 		5 / 9 ALA A 142
ALA A 122
VAL A 197
GLY A 200
ALA A 202
 None
 1.22A 4qvnK-4f47A:
undetectable
4qvnL-4f47A:
undetectable		 4qvnK-4f47A:
25.54
4qvnL-4f47A:
25.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4f47 ENOYL-COA HYDRATASE
ECHA19
(Mycobacterium
marinum) 		5 / 9 ALA A 142
ALA A 122
VAL A 197
GLY A 200
ALA A 202
 None
 1.22A 4qvnY-4f47A:
undetectable
4qvnZ-4f47A:
undetectable		 4qvnY-4f47A:
25.54
4qvnZ-4f47A:
25.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4f47 ENOYL-COA HYDRATASE
ECHA19
(Mycobacterium
marinum) 		5 / 10 ALA A 184
THR A 183
ALA A 187
VAL A 196
GLY A 120
 None
 0.99A 4qvyK-4f47A:
undetectable
4qvyL-4f47A:
undetectable		 4qvyK-4f47A:
23.33
4qvyL-4f47A:
25.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4f47 ENOYL-COA HYDRATASE
ECHA19
(Mycobacterium
marinum) 		5 / 10 ALA A 184
THR A 183
ALA A 187
VAL A 196
GLY A 120
 None
 0.99A 4qvyY-4f47A:
undetectable
4qvyZ-4f47A:
undetectable		 4qvyY-4f47A:
23.33
4qvyZ-4f47A:
25.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZME_A_ADNA1002_1
(MYOSIN HEAVY CHAIN
KINASE A)		 4f47 ENOYL-COA HYDRATASE
ECHA19
(Mycobacterium
marinum) 		5 / 11 PHE A 144
GLY A 191
VAL A 118
LEU A  66
THR A 133
 None
 1.13A 4zmeA-4f47A:
undetectable		 4zmeA-4f47A:
20.66