SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4f4c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DY4_A_SNPA437_1
(EXOGLUCANASE 1)		 4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1
(Caenorhabditis
elegans) 		5 / 12 ALA A 308
SER A 822
GLU A 267
THR A 868
ARG A 873
 None
 1.31A 1dy4A-4f4cA:
undetectable		 1dy4A-4f4cA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_A_9CRA165_1
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1
(Caenorhabditis
elegans) 		5 / 12 ILE A1005
MET A1021
VAL A1017
LEU A1018
VAL A 135
 None
 1.04A 1epbA-4f4cA:
undetectable		 1epbA-4f4cA:
8.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_A_MK1A401_2
(HIV-II PROTEASE)		 4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1
(Caenorhabditis
elegans) 		5 / 9 ALA A1190
ILE A1174
VAL A1182
ILE A1169
ILE A1173
 None
 0.93A 1hshB-4f4cA:
undetectable		 1hshB-4f4cA:
5.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JLF_A_NVPA999_1
(HIV-1 RT A-CHAIN
HIV-1 RT B-CHAIN)		 4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1
(Caenorhabditis
elegans) 		4 / 8 VAL A 548
CYH A 506
GLY A 549
GLU A 940
 None
 0.98A 1jlfA-4f4cA:
undetectable
1jlfB-4f4cA:
3.0		 1jlfA-4f4cA:
16.74
1jlfB-4f4cA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_G_AG2G7003_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1
(Caenorhabditis
elegans) 		4 / 6 LEU A1164
LEU A 291
GLY A1176
ILE A1174
 None
 0.89A 1mt1G-4f4cA:
undetectable
1mt1J-4f4cA:
undetectable		 1mt1G-4f4cA:
4.38
1mt1J-4f4cA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OIP_A_VIVA1278_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1
(Caenorhabditis
elegans) 		5 / 12 ILE A1143
ILE A1238
ILE A1270
LEU A1110
VAL A1288
 None
 1.04A 1oipA-4f4cA:
undetectable		 1oipA-4f4cA:
12.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PNL_B_PACB559_0
(PENICILLIN
AMIDOHYDROLASE)		 4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1
(Caenorhabditis
elegans) 		4 / 8 PHE A 789
ALA A 783
ILE A 110
ASN A 780
 None
 1.20A 1pnlA-4f4cA:
undetectable
1pnlB-4f4cA:
2.3		 1pnlA-4f4cA:
9.39
1pnlB-4f4cA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_B_ADNB1502_1
(CLASS B ACID
PHOSPHATASE)		 4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1
(Caenorhabditis
elegans) 		4 / 7 PHE A 323
LEU A 319
THR A  27
LYS A  30
 None
None
None
0SA  A1406 ( 4.1A)
 1.18A 1rmtB-4f4cA:
undetectable		 1rmtB-4f4cA:
9.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_B_VIBB504_1
(YKOF)		 4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1
(Caenorhabditis
elegans) 		4 / 6 PHE A 263
LEU A 317
ILE A 321
SER A 259
 None
 1.22A 1sbrA-4f4cA:
undetectable
1sbrB-4f4cA:
undetectable		 1sbrA-4f4cA:
9.19
1sbrB-4f4cA:
9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U1J_A_C2FA773_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)		 4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1
(Caenorhabditis
elegans) 		4 / 8 ARG A 205
ASN A  58
SER A 387
VAL A  56
 None
 1.23A 1u1jA-4f4cA:
undetectable		 1u1jA-4f4cA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_F_CLMF1144_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1
(Caenorhabditis
elegans) 		4 / 7 GLY A 454
THR A 459
ILE A 433
GLY A 456
 None
 0.82A 1usqF-4f4cA:
undetectable		 1usqF-4f4cA:
7.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VID_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1
(Caenorhabditis
elegans) 		4 / 5 GLU A 297
TYR A 296
SER A 283
ASP A1166
 None
 1.49A 1vidA-4f4cA:
undetectable		 1vidA-4f4cA:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VID_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1
(Caenorhabditis
elegans) 		4 / 5 GLU A 297
TYR A 296
SER A 284
ASP A1166
 None
 1.23A 1vidA-4f4cA:
undetectable		 1vidA-4f4cA:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y0X_X_T44X500_1
(THYROID HORMONE
RECEPTOR BETA-1)		 4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1
(Caenorhabditis
elegans) 		5 / 12 ILE A 110
ALA A 783
ARG A1019
ILE A1005
PHE A 119
 None
 1.31A 1y0xX-4f4cA:
undetectable		 1y0xX-4f4cA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_A_NFZA1219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1
(Caenorhabditis
elegans) 		4 / 8 PHE A  17
GLY A 365
THR A 239
PHE A 228
 None
 1.02A 1ykiA-4f4cA:
undetectable
1ykiB-4f4cA:
undetectable		 1ykiA-4f4cA:
11.54
1ykiB-4f4cA:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_A_NFZA1219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1
(Caenorhabditis
elegans) 		4 / 8 PHE A 504
ASN A 505
GLY A 549
THR A 546
 None
 1.08A 1ykiA-4f4cA:
undetectable
1ykiB-4f4cA:
undetectable		 1ykiA-4f4cA:
11.54
1ykiB-4f4cA:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_B_NFZB2219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1
(Caenorhabditis
elegans) 		4 / 8 THR A 239
PHE A 228
PHE A  17
GLY A 365
 None
 1.06A 1ykiA-4f4cA:
undetectable
1ykiB-4f4cA:
undetectable		 1ykiA-4f4cA:
11.54
1ykiB-4f4cA:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_B_NFZB2219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1
(Caenorhabditis
elegans) 		4 / 8 THR A 546
PHE A 504
ASN A 505
GLY A 549
 None
 1.09A 1ykiA-4f4cA:
undetectable
1ykiB-4f4cA:
undetectable		 1ykiA-4f4cA:
11.54
1ykiB-4f4cA:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_C_NFZC3219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1
(Caenorhabditis
elegans) 		4 / 8 PHE A  17
GLY A 365
THR A 239
PHE A 228
 None
 1.01A 1ykiC-4f4cA:
undetectable
1ykiD-4f4cA:
undetectable		 1ykiC-4f4cA:
11.54
1ykiD-4f4cA:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_C_NFZC3219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1
(Caenorhabditis
elegans) 		4 / 8 PHE A 504
ASN A 505
GLY A 549
THR A 546
 None
 1.08A 1ykiC-4f4cA:
undetectable
1ykiD-4f4cA:
undetectable		 1ykiC-4f4cA:
11.54
1ykiD-4f4cA:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_D_NFZD4219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1
(Caenorhabditis
elegans) 		4 / 8 THR A 239
PHE A 228
PHE A  17
GLY A 365
 None
 0.98A 1ykiC-4f4cA:
undetectable
1ykiD-4f4cA:
undetectable		 1ykiC-4f4cA:
11.54
1ykiD-4f4cA:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZVI_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1
(Caenorhabditis
elegans) 		3 / 3 ARG A1019
VAL A 781
TRP A 796
 None
 1.26A 1zviA-4f4cA:
3.0		 1zviA-4f4cA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_A_RBFA300_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1
(Caenorhabditis
elegans) 		5 / 11 GLY A 935
SER A 934
LEU A 965
ILE A 942
ALA A 196
 None
 1.33A 2a58A-4f4cA:
undetectable
2a58E-4f4cA:
undetectable		 2a58A-4f4cA:
7.79
2a58E-4f4cA:
7.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_B_RBFB301_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1
(Caenorhabditis
elegans) 		5 / 12 ILE A 942
ALA A 196
GLY A 935
SER A 934
LEU A 965
 None
 1.32A 2a58A-4f4cA:
undetectable
2a58B-4f4cA:
undetectable		 2a58A-4f4cA:
7.79
2a58B-4f4cA:
7.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_D_RBFD303_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1
(Caenorhabditis
elegans) 		5 / 11 ILE A 942
ALA A 196
GLY A 935
SER A 934
LEU A 965
 None
 1.33A 2a58C-4f4cA:
undetectable
2a58D-4f4cA:
undetectable		 2a58C-4f4cA:
7.79
2a58D-4f4cA:
7.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_E_RBFE304_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1
(Caenorhabditis
elegans) 		5 / 12 ILE A 942
ALA A 196
GLY A 935
SER A 934
LEU A 965
 None
 1.31A 2a58D-4f4cA:
undetectable
2a58E-4f4cA:
undetectable		 2a58D-4f4cA:
7.79
2a58E-4f4cA:
7.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_A_SAMA301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1
(Caenorhabditis
elegans) 		3 / 3 LYS A1057
ASP A 846
ASN A 850
 None
 1.15A 2bm9A-4f4cA:
undetectable		 2bm9A-4f4cA:
9.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYO_A_LNLA1217_1
(LIPOPROTEIN LPPX)		 4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1
(Caenorhabditis
elegans) 		4 / 4 VAL A 470
LEU A 449
ILE A 609
LEU A 577
 None
 1.04A 2byoA-4f4cA:
undetectable		 2byoA-4f4cA:
10.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CL5_B_SAMB1217_1
(CATECHOL
O-METHYLTRANSFERASE)		 4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1
(Caenorhabditis
elegans) 		4 / 6 GLU A 297
TYR A 296
SER A 284
ASP A1166
 None
 1.20A 2cl5B-4f4cA:
undetectable		 2cl5B-4f4cA:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COJ_A_GBNA420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1
(Caenorhabditis
elegans) 		5 / 11 PHE A 323
MET A 818
GLY A 757
THR A 760
ALA A 761
 None
 1.43A 2cojA-4f4cA:
undetectable
2cojB-4f4cA:
undetectable		 2cojA-4f4cA:
15.07
2cojB-4f4cA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DCF_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1
(Caenorhabditis
elegans) 		4 / 6 ALA A 619
TYR A 646
ILE A 608
ILE A 622
 None
 1.24A 2dcfA-4f4cA:
undetectable		 2dcfA-4f4cA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H77_A_T3A1_1
(THRA PROTEIN)		 4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1
(Caenorhabditis
elegans) 		5 / 12 ILE A 870
ALA A 869
ALA A1047
LEU A 829
ILE A1051
 None
 1.08A 2h77A-4f4cA:
undetectable		 2h77A-4f4cA:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H77_A_T3A1_1
(THRA PROTEIN)		 4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1
(Caenorhabditis
elegans) 		5 / 12 ILE A1272
ALA A1286
LEU A1108
LEU A1098
ILE A1293
 None
 1.16A 2h77A-4f4cA:
undetectable		 2h77A-4f4cA:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H79_A_T3A1_1
(THRA PROTEIN)		 4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1
(Caenorhabditis
elegans) 		5 / 12 ILE A 870
ALA A 869
ALA A1047
LEU A 829
ILE A1051
 None
 1.07A 2h79A-4f4cA:
undetectable		 2h79A-4f4cA:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_E_CLME1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1
(Caenorhabditis
elegans) 		4 / 7 GLY A 454
THR A 459
ILE A 433
GLY A 456
 None
 0.81A 2jkjE-4f4cA:
undetectable		 2jkjE-4f4cA:
7.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_A_CLMA1144_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1
(Caenorhabditis
elegans) 		4 / 7 GLY A 454
THR A 459
ILE A 433
GLY A 456
 None
 0.83A 2jklA-4f4cA:
undetectable		 2jklA-4f4cA:
7.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_C_CLMC1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1
(Caenorhabditis
elegans) 		4 / 7 GLY A 454
THR A 459
ILE A 433
GLY A 456
 None
 0.83A 2jklC-4f4cA:
undetectable		 2jklC-4f4cA:
7.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_D_CLMD1145_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1
(Caenorhabditis
elegans) 		4 / 7 GLY A 454
THR A 459
ILE A 433
GLY A 456
 None
 0.81A 2jklD-4f4cA:
undetectable		 2jklD-4f4cA:
7.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_E_CLME1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1
(Caenorhabditis
elegans) 		4 / 7 GLY A 454
THR A 459
ILE A 433
GLY A 456
 None
 0.82A 2jklE-4f4cA:
undetectable		 2jklE-4f4cA:
7.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_F_CLMF1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1
(Caenorhabditis
elegans) 		4 / 7 GLY A 454
THR A 459
ILE A 433
GLY A 456
 None
 0.82A 2jklF-4f4cA:
undetectable		 2jklF-4f4cA:
7.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZ7_A_CA4A1_1
(ANDROGEN RECEPTOR)		 4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1
(Caenorhabditis
elegans) 		5 / 12 LEU A 376
LEU A 379
GLY A 380
GLN A 383
LEU A  14
 None
 1.06A 2oz7A-4f4cA:
undetectable		 2oz7A-4f4cA:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQD_B_AG2B671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1
(Caenorhabditis
elegans) 		4 / 8 ILE A1174
LEU A1164
LEU A 291
GLY A1176
 None
 0.82A 2qqdB-4f4cA:
undetectable
2qqdC-4f4cA:
undetectable		 2qqdB-4f4cA:
6.36
2qqdC-4f4cA:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX4_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1
(Caenorhabditis
elegans) 		4 / 7 GLY A 765
CYH A 810
GLN A 807
PHE A 323
 None
 1.07A 2qx4A-4f4cA:
undetectable
2qx4B-4f4cA:
undetectable		 2qx4A-4f4cA:
10.78
2qx4B-4f4cA:
10.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_C_RIMC399_1
(MATRIX PROTEIN 2)		 4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1
(Caenorhabditis
elegans) 		4 / 6 LEU A 825
LEU A 829
ILE A 870
ARG A 867
 None
 0.96A 2rlfC-4f4cA:
undetectable
2rlfD-4f4cA:
undetectable		 2rlfC-4f4cA:
3.11
2rlfD-4f4cA:
3.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN6_A_T44A1370_1
(THYROXINE-BINDING
GLOBULIN)		 4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1
(Caenorhabditis
elegans) 		5 / 10 LEU A 203
LYS A 177
LEU A 171
ARG A 172
ARG A 173
 None
 1.12A 2xn6A-4f4cA:
undetectable
2xn6B-4f4cA:
undetectable		 2xn6A-4f4cA:
13.72
2xn6B-4f4cA:
2.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y03_A_5FWA601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1
(Caenorhabditis
elegans) 		5 / 12 VAL A 362
SER A  18
SER A 366
PHE A 334
ASN A 330
 None
 1.38A 2y03A-4f4cA:
undetectable		 2y03A-4f4cA:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_C_ZMRC1776_2
(NEURAMINIDASE A)		 4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1
(Caenorhabditis
elegans) 		4 / 6 ARG A 725
ASP A 862
ILE A1051
TYR A 301
 None
 1.32A 2ya7C-4f4cA:
undetectable		 2ya7C-4f4cA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZVJ_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1
(Caenorhabditis
elegans) 		4 / 6 GLU A 297
TYR A 296
SER A 284
ASP A1166
 None
 1.21A 2zvjA-4f4cA:
undetectable		 2zvjA-4f4cA:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AMU_A_AG2A422_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1
(Caenorhabditis
elegans) 		4 / 5 GLU A 940
ASN A 511
VAL A 548
CYH A 506
 None
 1.37A 3amuA-4f4cA:
undetectable		 3amuA-4f4cA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BPX_A_SALA257_1
(TRANSCRIPTIONAL
REGULATOR)		 4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1
(Caenorhabditis
elegans) 		4 / 8 SER A 102
PHE A 775
THR A1025
ILE A1026
 None
 0.92A 3bpxA-4f4cA:
undetectable
3bpxB-4f4cA:
undetectable		 3bpxA-4f4cA:
8.71
3bpxB-4f4cA:
8.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_H_TOPH200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1
(Caenorhabditis
elegans) 		5 / 9 ALA A 761
ILE A 870
LEU A 744
PHE A 874
THR A 762
 None
 1.32A 3fl9H-4f4cA:
2.1		 3fl9H-4f4cA:
7.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWS_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA)		 4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1
(Caenorhabditis
elegans) 		5 / 12 ILE A 870
ALA A 869
ALA A1047
LEU A 829
ILE A1051
 None
 1.04A 3gwsX-4f4cA:
undetectable		 3gwsX-4f4cA:
12.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_O_TFPO202_1
(PROTEIN S100-A4)		 4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1
(Caenorhabditis
elegans) 		5 / 11 LEU A 803
PHE A 331
ILE A 767
CYH A 810
PHE A 812
 None
 1.44A 3ko0O-4f4cA:
undetectable
3ko0P-4f4cA:
undetectable
3ko0Q-4f4cA:
0.6
3ko0R-4f4cA:
undetectable		 3ko0O-4f4cA:
5.53
3ko0P-4f4cA:
5.53
3ko0Q-4f4cA:
5.53
3ko0R-4f4cA:
5.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP2_A_PNNA5001_0
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1
(Caenorhabditis
elegans) 		4 / 8 ASN A 944
THR A 947
LEU A 951
ARG A 567
 None
 0.65A 3kp2A-4f4cA:
undetectable
3kp2B-4f4cA:
undetectable		 3kp2A-4f4cA:
8.18
3kp2B-4f4cA:
8.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA302_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		 4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1
(Caenorhabditis
elegans) 		4 / 6 LEU A1064
GLU A1149
PRO A1148
ARG A 295
 None
 1.29A 3ltwA-4f4cA:
undetectable		 3ltwA-4f4cA:
13.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1
(Caenorhabditis
elegans) 		4 / 7 TYR A 467
VAL A 441
VAL A 494
ILE A 475
 None
 1.07A 3mssB-4f4cA:
undetectable		 3mssB-4f4cA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK2_X_LDPX433_1
(6-HYDROXY-L-NICOTINE
OXIDASE)		 4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1
(Caenorhabditis
elegans) 		4 / 7 TYR A  66
ASN A 168
LEU A 393
LEU A  65
 None
 1.30A 3nk2X-4f4cA:
undetectable		 3nk2X-4f4cA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZV_B_ECNB411_1
(FLAVOHEMOGLOBIN)		 4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1
(Caenorhabditis
elegans) 		5 / 9 ILE A 767
TYR A 768
GLN A 807
ALA A 804
LEU A 803
 None
 1.08A 3ozvB-4f4cA:
undetectable		 3ozvB-4f4cA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGT_B_CP6B609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1
(Caenorhabditis
elegans) 		5 / 10 ILE A 575
ALA A 443
ASP A 415
ILE A 623
ILE A 607
 None
 1.26A 3qgtB-4f4cA:
undetectable		 3qgtB-4f4cA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SEL_X_DXCX75_0
(CYTOCHROME C7)		 4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1
(Caenorhabditis
elegans) 		4 / 8 ILE A 460
LEU A 464
LYS A 413
GLY A 414
 None
 1.05A 3selX-4f4cA:
undetectable		 3selX-4f4cA:
4.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SMT_A_ACTA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3)		 4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1
(Caenorhabditis
elegans) 		3 / 3 PHE A 920
SER A 982
GLN A 979
 None
 0.91A 3smtA-4f4cA:
undetectable		 3smtA-4f4cA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_A_9PLA501_1
(CYTOCHROME P450 2E1)		 4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1
(Caenorhabditis
elegans) 		4 / 6 PHE A1079
LEU A1110
ALA A1123
LEU A1095
 None
 0.87A 3t3zA-4f4cA:
2.2		 3t3zA-4f4cA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_B_9PLB501_1
(CYTOCHROME P450 2E1)		 4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1
(Caenorhabditis
elegans) 		4 / 6 PHE A1079
LEU A1110
ALA A1123
LEU A1095
 None
 0.87A 3t3zB-4f4cA:
2.3		 3t3zB-4f4cA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_D_9PLD501_1
(CYTOCHROME P450 2E1)		 4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1
(Caenorhabditis
elegans) 		4 / 6 PHE A1079
LEU A1110
ALA A1123
LEU A1095
 None
 0.87A 3t3zD-4f4cA:
2.2		 3t3zD-4f4cA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1
(Caenorhabditis
elegans) 		4 / 7 ILE A 106
PHE A 778
HIS A 234
VAL A 362
 None
 1.01A 4a97A-4f4cA:
4.2		 4a97A-4f4cA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1
(Caenorhabditis
elegans) 		4 / 7 ILE A 106
PHE A 778
HIS A 234
VAL A 362
 None
 1.01A 4a97D-4f4cA:
undetectable		 4a97D-4f4cA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1
(Caenorhabditis
elegans) 		4 / 6 ILE A 106
PHE A 778
HIS A 234
VAL A 362
 None
 1.04A 4a97I-4f4cA:
undetectable		 4a97I-4f4cA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1
(Caenorhabditis
elegans) 		4 / 7 GLU A  36
TYR A  35
GLY A   5
ARG A   8
 None
 0.89A 4fgzA-4f4cA:
undetectable		 4fgzA-4f4cA:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1
(Caenorhabditis
elegans) 		4 / 8 GLU A  36
TYR A  35
GLY A   5
ARG A   8
 None
 1.01A 4fgzA-4f4cA:
undetectable
4fgzB-4f4cA:
undetectable		 4fgzA-4f4cA:
12.19
4fgzB-4f4cA:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HBF_A_DXCA75_0
(PPCA)		 4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1
(Caenorhabditis
elegans) 		4 / 7 ILE A 460
LEU A 464
LYS A 413
GLY A 414
 None
 0.97A 4hbfA-4f4cA:
undetectable		 4hbfA-4f4cA:
4.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HC3_A_DXCA75_0
(PPCA)		 4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1
(Caenorhabditis
elegans) 		4 / 7 ILE A 460
LEU A 464
LYS A 413
GLY A 414
 None
 1.03A 4hc3A-4f4cA:
undetectable		 4hc3A-4f4cA:
4.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IMA_D_ADND604_1
(PYRUVATE KINASE)		 4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1
(Caenorhabditis
elegans) 		3 / 3 ARG A 858
GLU A 729
ASN A 733
 None
 0.90A 4imaD-4f4cA:
undetectable		 4imaD-4f4cA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA502_0
(RNA POLYMERASE
3D-POL)		 4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1
(Caenorhabditis
elegans) 		3 / 3 ARG A  12
LYS A  26
LYS A  30
 None
0SA  A1406 (-4.5A)
0SA  A1406 ( 4.1A)
 1.40A 4k50A-4f4cA:
undetectable		 4k50A-4f4cA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KN2_C_LYAC304_2
(FOLATE RECEPTOR BETA)		 4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1
(Caenorhabditis
elegans) 		3 / 3 TYR A 991
GLN A 219
TRP A 150
 None
 1.02A 4kn2C-4f4cA:
undetectable		 4kn2C-4f4cA:
8.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1
(Caenorhabditis
elegans) 		5 / 12 ILE A 870
ALA A 869
ALA A1047
LEU A 829
ILE A1051
 None
 1.06A 4lnwA-4f4cA:
undetectable		 4lnwA-4f4cA:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1
(Caenorhabditis
elegans) 		5 / 12 ILE A1272
ALA A1286
LEU A1108
LEU A1098
ILE A1293
 None
 1.12A 4lnwA-4f4cA:
undetectable		 4lnwA-4f4cA:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T3A502_1
(THYROID HORMONE
RECEPTOR ALPHA)		 4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1
(Caenorhabditis
elegans) 		5 / 12 ILE A 870
ALA A 869
ALA A1047
LEU A 829
ILE A1051
 None
 1.08A 4lnxA-4f4cA:
undetectable		 4lnxA-4f4cA:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T3A502_1
(THYROID HORMONE
RECEPTOR ALPHA)		 4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1
(Caenorhabditis
elegans) 		5 / 12 ILE A1272
ALA A1286
LEU A1108
LEU A1098
ILE A1293
 None
 1.13A 4lnxA-4f4cA:
undetectable		 4lnxA-4f4cA:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_2
(GLUCOCORTICOID
RECEPTOR)		 4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1
(Caenorhabditis
elegans) 		3 / 3 MET A1015
MET A1000
TYR A1022
 None
 1.29A 4p6xI-4f4cA:
undetectable		 4p6xI-4f4cA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0S_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1
(Caenorhabditis
elegans) 		6 / 12 LEU A1110
ILE A1270
ILE A1238
VAL A1077
LEU A1098
PHE A1079
 None
 1.35A 4y0sA-4f4cA:
undetectable		 4y0sA-4f4cA:
8.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0S_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1
(Caenorhabditis
elegans) 		6 / 12 LEU A1110
LEU A1108
ILE A1270
VAL A1077
LEU A1098
PHE A1079
 None
 1.17A 4y0sA-4f4cA:
undetectable		 4y0sA-4f4cA:
8.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_J_4LEJ401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1
(Caenorhabditis
elegans) 		6 / 9 LEU A 740
LEU A 744
ALA A 747
LEU A 754
ALA A 821
ALA A 869
 None
 1.17A 4z91F-4f4cA:
4.3
4z91G-4f4cA:
4.1
4z91H-4f4cA:
4.2
4z91I-4f4cA:
4.8
4z91J-4f4cA:
4.1		 4z91F-4f4cA:
13.90
4z91G-4f4cA:
13.90
4z91H-4f4cA:
13.90
4z91I-4f4cA:
13.90
4z91J-4f4cA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_J_4LEJ401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1
(Caenorhabditis
elegans) 		6 / 9 LEU A 754
ALA A 821
ALA A 869
LEU A 740
LEU A 744
ALA A 747
 None
 1.10A 4z91F-4f4cA:
4.3
4z91G-4f4cA:
4.1
4z91H-4f4cA:
4.2
4z91I-4f4cA:
4.8
4z91J-4f4cA:
4.1		 4z91F-4f4cA:
13.90
4z91G-4f4cA:
13.90
4z91H-4f4cA:
13.90
4z91I-4f4cA:
13.90
4z91J-4f4cA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CXV_A_0HKA501_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M1,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M1)		 4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1
(Caenorhabditis
elegans) 		3 / 3 THR A1045
THR A 738
PHE A 741
 None
 0.91A 5cxvA-4f4cA:
2.8		 5cxvA-4f4cA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_B_FOLB201_1
(DIHYDROFOLATE
REDUCTASE)		 4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1
(Caenorhabditis
elegans) 		3 / 3 ASP A  38
ARG A 867
ARG A 873
 None
 0.95A 5eajB-4f4cA:
undetectable		 5eajB-4f4cA:
8.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHR_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1
(Caenorhabditis
elegans) 		4 / 5 GLU A 297
TYR A 296
SER A 283
ASP A1166
 None
 1.45A 5fhrA-4f4cA:
undetectable		 5fhrA-4f4cA:
10.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHR_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1
(Caenorhabditis
elegans) 		4 / 5 GLU A 297
TYR A 296
SER A 284
ASP A1166
 None
 1.19A 5fhrA-4f4cA:
undetectable		 5fhrA-4f4cA:
10.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOC_A_SAMA401_0
(PAVINE
N-METHYLTRANSFERASE)		 4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1
(Caenorhabditis
elegans) 		5 / 12 GLY A1117
VAL A1082
VAL A1122
ALA A1123
LEU A1124
 None
 0.92A 5kocA-4f4cA:
undetectable		 5kocA-4f4cA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M54_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1
(Caenorhabditis
elegans) 		5 / 12 VAL A1187
ALA A1229
THR A1163
GLY A1176
LEU A 291
 None
 1.12A 5m54E-4f4cA:
3.2		 5m54E-4f4cA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA608_0
(ALPHA-AMYLASE)		 4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1
(Caenorhabditis
elegans) 		4 / 6 PHE A1052
GLY A1048
THR A 738
TYR A1041
 None
 1.20A 6ag0A-4f4cA:
undetectable		 6ag0A-4f4cA:
5.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC606_0
(ALPHA-AMYLASE)		 4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1
(Caenorhabditis
elegans) 		4 / 6 PHE A1052
GLY A1048
THR A 738
TYR A1041
 None
 1.23A 6ag0C-4f4cA:
undetectable		 6ag0C-4f4cA:
5.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1
(Caenorhabditis
elegans) 		4 / 8 ILE A 282
THR A 281
THR A1163
LYS A1223
 None
 1.07A 6c06C-4f4cA:
undetectable		 6c06C-4f4cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA810_0
(GEPHYRIN)		 4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1
(Caenorhabditis
elegans) 		3 / 3 LEU A 813
SER A 811
PHE A 812
 None
 0.65A 6fgcA-4f4cA:
undetectable		 6fgcA-4f4cA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		 4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1
(Caenorhabditis
elegans) 		5 / 11 ALA A 596
LEU A 597
ALA A 495
ALA A 564
LEU A 569
 None
 1.03A 6h1lB-4f4cA:
undetectable		 6h1lB-4f4cA:
17.30