SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4f4f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW5_A_SAMA401_1
(MODIFICATION
METHYLASE RSRI)		 4f4f THREONINE SYNTHASE
(Brucella
melitensis) 		3 / 3 ASP A 309
HIS A 386
ASP A 143
 None
PLP  A 501 (-3.8A)
None
 0.74A 1nw5A-4f4fA:
undetectable		 1nw5A-4f4fA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_A_SAMA301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4f4f THREONINE SYNTHASE
(Brucella
melitensis) 		3 / 3 LYS A 112
ASP A 309
ASP A 282
 PLP  A 501 (-1.7A)
None
None
 1.13A 2br4A-4f4fA:
2.3		 2br4A-4f4fA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C49_A_ADNA1301_1
(SUGAR KINASE MJ0406)		 4f4f THREONINE SYNTHASE
(Brucella
melitensis) 		5 / 12 ALA A  24
ASP A  26
GLY A  27
GLY A  28
ALA A  10
 None
 1.00A 2c49A-4f4fA:
undetectable		 2c49A-4f4fA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 4f4f THREONINE SYNTHASE
(Brucella
melitensis) 		5 / 12 SER A 287
THR A 409
ILE A 389
ASN A 281
SER A 305
 None
PLP  A 501 (-3.1A)
None
None
None
 1.42A 2vdyB-4f4fA:
undetectable		 2vdyB-4f4fA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_C_IBPC1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 4f4f THREONINE SYNTHASE
(Brucella
melitensis) 		5 / 10 THR A 304
ILE A 372
LEU A 383
VAL A 391
GLY A 390
 None
 1.11A 2wd9C-4f4fA:
undetectable		 2wd9C-4f4fA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4f4f THREONINE SYNTHASE
(Brucella
melitensis) 		4 / 6 PHE A 111
THR A 144
ALA A 410
ALA A 110
 PLP  A 501 (-4.3A)
None
PLP  A 501 (-3.6A)
PLP  A 501 ( 4.9A)
 1.15A 3ns1C-4f4fA:
undetectable		 3ns1C-4f4fA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_B_0LIB1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4f4f THREONINE SYNTHASE
(Brucella
melitensis) 		5 / 9 LEU A 383
ILE A 310
LEU A 286
ILE A 278
ILE A 260
 None
 1.13A 3zosB-4f4fA:
undetectable		 3zosB-4f4fA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZT_A_SAMA1472_1
(METHYLTRANSFERASE
WBDD)		 4f4f THREONINE SYNTHASE
(Brucella
melitensis) 		3 / 3 GLN A 176
ASP A 113
GLN A 117
 None
 0.93A 4aztA-4f4fA:
2.8		 4aztA-4f4fA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_A_BRLA501_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4f4f THREONINE SYNTHASE
(Brucella
melitensis) 		4 / 5 LEU A 127
ILE A 136
LEU A 119
LEU A  13
 None
 0.83A 4o8fA-4f4fA:
undetectable		 4o8fA-4f4fA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_A_30ZA201_1
(TRANSTHYRETIN)		 4f4f THREONINE SYNTHASE
(Brucella
melitensis) 		4 / 6 LEU A 382
THR A 368
LEU A 376
SER A 377
 None
 1.05A 4pwjA-4f4fA:
undetectable		 4pwjA-4f4fA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOG_B_ML1B302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4f4f THREONINE SYNTHASE
(Brucella
melitensis) 		4 / 6 GLY A 293
PHE A 316
ILE A 354
PHE A 257
 None
 0.99A 4qogA-4f4fA:
undetectable
4qogB-4f4fA:
undetectable		 4qogA-4f4fA:
16.18
4qogB-4f4fA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_B_ML1B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4f4f THREONINE SYNTHASE
(Brucella
melitensis) 		5 / 11 GLY A 343
GLY A 342
GLY A 293
PHE A 316
ILE A 285
 None
 0.99A 4qoiA-4f4fA:
undetectable
4qoiB-4f4fA:
undetectable		 4qoiA-4f4fA:
16.18
4qoiB-4f4fA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C6P_A_4YHA601_1
(PROTEIN C)		 4f4f THREONINE SYNTHASE
(Brucella
melitensis) 		4 / 6 SER A 170
SER A 307
ASP A 384
PRO A 385
 None
PLP  A 501 (-3.3A)
None
None
 0.81A 5c6pA-4f4fA:
undetectable		 5c6pA-4f4fA:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 4f4f THREONINE SYNTHASE
(Brucella
melitensis) 		4 / 8 SER A 217
ALA A 463
ASP A 159
SER A 461
 None
 1.05A 5l5fY-4f4fA:
undetectable
5l5fZ-4f4fA:
undetectable		 5l5fY-4f4fA:
17.21
5l5fZ-4f4fA:
21.30