SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4f4h'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1873_0
(FPRA)		 4f4h GLUTAMINE DEPENDENT
NAD+ SYNTHETASE
(Burkholderia
thailandensis) 		3 / 3 ASP A 198
ASP A 231
LYS A 246
 None
 1.16A 1lqtB-4f4hA:
2.8		 1lqtB-4f4hA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1430_0
(FPRA)		 4f4h GLUTAMINE DEPENDENT
NAD+ SYNTHETASE
(Burkholderia
thailandensis) 		3 / 3 ASP A 198
ASP A 231
LYS A 246
 None
 1.17A 1lquB-4f4hA:
2.4		 1lquB-4f4hA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_SAMA293_1
(GLYCINE
N-METHYLTRANSFERASE)		 4f4h GLUTAMINE DEPENDENT
NAD+ SYNTHETASE
(Burkholderia
thailandensis) 		3 / 3 ARG A 530
ASP A 500
ASN A  99
 None
 0.81A 1nbhA-4f4hA:
3.8		 1nbhA-4f4hA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_1
(GLYCINE
N-METHYLTRANSFERASE)		 4f4h GLUTAMINE DEPENDENT
NAD+ SYNTHETASE
(Burkholderia
thailandensis) 		3 / 3 ARG A 530
ASP A 500
ASN A  99
 None
 0.79A 1nbhD-4f4hA:
undetectable		 1nbhD-4f4hA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXC_A_P1ZA2001_1
(SERUM ALBUMIN)		 4f4h GLUTAMINE DEPENDENT
NAD+ SYNTHETASE
(Burkholderia
thailandensis) 		5 / 12 LEU A  81
LEU A  39
ALA A 255
ILE A 256
ALA A  30
 None
 1.07A 2bxcA-4f4hA:
undetectable		 2bxcA-4f4hA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYO_A_LNLA1216_1
(LIPOPROTEIN LPPX)		 4f4h GLUTAMINE DEPENDENT
NAD+ SYNTHETASE
(Burkholderia
thailandensis) 		4 / 5 LEU A  71
ILE A 118
LEU A 117
SER A 116
 None
 0.83A 2byoA-4f4hA:
1.1		 2byoA-4f4hA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_NCAA493_0
(CHORISMATE SYNTHASE)		 4f4h GLUTAMINE DEPENDENT
NAD+ SYNTHETASE
(Burkholderia
thailandensis) 		5 / 11 ILE A 464
MET A 346
ALA A 314
ALA A 310
VAL A 307
 None
 0.96A 2qhfA-4f4hA:
undetectable		 2qhfA-4f4hA:
25.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WLJ_A_SPMA1303_1
(POTASSIUM CHANNEL)		 4f4h GLUTAMINE DEPENDENT
NAD+ SYNTHETASE
(Burkholderia
thailandensis) 		3 / 3 ARG A 501
ARG A  57
PRO A  58
 None
 1.14A 2wljA-4f4hA:
undetectable		 2wljA-4f4hA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDT_A_VORA506_1
(CHOLESTEROL
24-HYDROXYLASE)		 4f4h GLUTAMINE DEPENDENT
NAD+ SYNTHETASE
(Burkholderia
thailandensis) 		5 / 9 LEU A 117
SER A 116
ILE A  40
ALA A  41
ALA A  28
 None
 1.32A 3mdtA-4f4hA:
undetectable		 3mdtA-4f4hA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4f4h GLUTAMINE DEPENDENT
NAD+ SYNTHETASE
(Burkholderia
thailandensis) 		5 / 12 GLY A 305
LEU A 407
GLY A 302
SER A 309
ALA A 316
 None
 1.04A 3sufA-4f4hA:
undetectable		 3sufA-4f4hA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0U_F_ASWF101_1
(DNA TOPOISOMERASE
2-BETA)		 4f4h GLUTAMINE DEPENDENT
NAD+ SYNTHETASE
(Burkholderia
thailandensis) 		4 / 6 PRO A 188
GLY A 161
ALA A 115
GLN A 175
 None
 1.10A 4g0uA-4f4hA:
undetectable		 4g0uA-4f4hA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JBT_B_ASDB502_1
(CYTOCHROME P450
MONOOXYGENASE)		 4f4h GLUTAMINE DEPENDENT
NAD+ SYNTHETASE
(Burkholderia
thailandensis) 		5 / 11 ALA A 173
ALA A 177
ALA A 174
THR A 212
LEU A 205
 None
 1.14A 4jbtB-4f4hA:
undetectable		 4jbtB-4f4hA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA409_0
(FAD:PROTEIN FMN
TRANSFERASE)		 4f4h GLUTAMINE DEPENDENT
NAD+ SYNTHETASE
(Burkholderia
thailandensis) 		4 / 5 ILE A 506
VAL A 516
ILE A 560
VAL A 507
 None
 0.75A 4xdtA-4f4hA:
undetectable		 4xdtA-4f4hA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)		 4f4h GLUTAMINE DEPENDENT
NAD+ SYNTHETASE
(Burkholderia
thailandensis) 		5 / 12 ILE A 405
VAL A 406
GLY A 298
VAL A 350
LEU A 313
 None
 1.15A 5ergB-4f4hA:
3.3		 5ergB-4f4hA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_A_GMJA301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 4f4h GLUTAMINE DEPENDENT
NAD+ SYNTHETASE
(Burkholderia
thailandensis) 		5 / 12 LEU A  84
ILE A 164
VAL A 168
LEU A  46
ALA A  45
 None
 1.02A 6djzA-4f4hA:
undetectable		 6djzA-4f4hA:
19.06