SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4f4m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MIC_A_DVAA6_0
(GRAMICIDIN A)		 4f4m PAPAIN PEPTIDOGLYCAN
AMIDASE EFFECTOR
TSE1
(Pseudomonas
aeruginosa) 		3 / 3 ALA A  39
VAL A  43
TRP A  61
 None
 0.90A 1micA-4f4mA:
undetectable
1micB-4f4mA:
undetectable		 1micA-4f4mA:
8.33
1micB-4f4mA:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UKB_A_BEZA1300_0
(2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE)		 4f4m PAPAIN PEPTIDOGLYCAN
AMIDASE EFFECTOR
TSE1
(Pseudomonas
aeruginosa) 		5 / 11 GLY A  77
ALA A  74
PHE A  78
VAL A  94
VAL A  95
 None
 1.00A 1ukbA-4f4mA:
undetectable		 1ukbA-4f4mA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_E_SC2E1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		 4f4m PAPAIN PEPTIDOGLYCAN
AMIDASE EFFECTOR
TSE1
(Pseudomonas
aeruginosa) 		3 / 3 VAL A 129
GLN A 121
CYH A 110
 None
 0.84A 5icxA-4f4mA:
undetectable
5icxE-4f4mA:
undetectable		 5icxA-4f4mA:
22.22
5icxE-4f4mA:
6.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_B_BEZB201_0
(NS3 PROTEASE)		 4f4m PAPAIN PEPTIDOGLYCAN
AMIDASE EFFECTOR
TSE1
(Pseudomonas
aeruginosa) 		4 / 5 HIS A  91
ALA A 114
SER A 112
GLY A 111
 None
 1.10A 5yodB-4f4mA:
undetectable		 5yodB-4f4mA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_D_BEZD201_0
(NS3 PROTEASE)		 4f4m PAPAIN PEPTIDOGLYCAN
AMIDASE EFFECTOR
TSE1
(Pseudomonas
aeruginosa) 		4 / 5 HIS A  91
ALA A 114
SER A 112
GLY A 111
 None
 1.16A 5yodD-4f4mA:
undetectable		 5yodD-4f4mA:
22.87