SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4f4o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZE_A_RBFA98_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 4f4o HAPTOGLOBIN
(Sus
scrofa) 		5 / 9 LEU C 164
LEU C 138
THR C 140
THR C 161
ILE C 158
 None
 1.39A 1hzeA-4f4oC:
1.2
1hzeB-4f4oC:
1.1		 1hzeA-4f4oC:
13.37
1hzeB-4f4oC:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZE_B_RBFB99_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 4f4o HAPTOGLOBIN
(Sus
scrofa) 		5 / 9 THR C 161
ILE C 158
LEU C 164
LEU C 138
THR C 140
 None
 1.40A 1hzeA-4f4oC:
1.2
1hzeB-4f4oC:
1.1		 1hzeA-4f4oC:
13.37
1hzeB-4f4oC:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_A_RBFA501_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 4f4o HAPTOGLOBIN
(Sus
scrofa) 		5 / 12 GLY C 129
SER C 298
ILE C 315
ILE C 191
LEU C 139
 None
 1.25A 1kyvA-4f4oC:
undetectable
1kyvE-4f4oC:
undetectable		 1kyvA-4f4oC:
19.32
1kyvE-4f4oC:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_C_RBFC503_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 4f4o HAPTOGLOBIN
(Sus
scrofa) 		5 / 12 ILE C 191
LEU C 139
GLY C 129
SER C 298
ILE C 315
 None
 1.26A 1kyvB-4f4oC:
undetectable
1kyvC-4f4oC:
undetectable		 1kyvB-4f4oC:
19.32
1kyvC-4f4oC:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_D_RBFD504_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 4f4o HAPTOGLOBIN
(Sus
scrofa) 		5 / 12 ILE C 191
LEU C 139
GLY C 129
SER C 298
ILE C 315
 None
 1.23A 1kyvC-4f4oC:
undetectable
1kyvD-4f4oC:
undetectable		 1kyvC-4f4oC:
19.32
1kyvD-4f4oC:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_E_RBFE505_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 4f4o HAPTOGLOBIN
(Sus
scrofa) 		5 / 12 ILE C 191
LEU C 139
GLY C 129
SER C 298
ILE C 315
 None
 1.22A 1kyvD-4f4oC:
undetectable
1kyvE-4f4oC:
undetectable		 1kyvD-4f4oC:
19.32
1kyvE-4f4oC:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7X_A_CFFA864_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 4f4o HAPTOGLOBIN
(Sus
scrofa) 		3 / 3 TRP C 225
HIS C 236
LYS C 238
 None
 1.38A 1l7xA-4f4oC:
undetectable		 1l7xA-4f4oC:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OHR_A_1UNA201_2
(ASPARTYLPROTEASE)		 4f4o HAPTOGLOBIN
(Sus
scrofa) 		5 / 9 LEU C 138
VAL C 177
ILE C 158
ILE C 121
ILE C 191
 None
 0.99A 1ohrB-4f4oC:
undetectable		 1ohrB-4f4oC:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EGV_A_SAMA1300_0
(UPF0088 PROTEIN
AQ_165)		 4f4o HAPTOGLOBIN
(Sus
scrofa) 		5 / 12 LEU C 139
GLY C 297
GLY C 129
LEU C 190
THR C 141
 None
 0.80A 2egvA-4f4oC:
undetectable		 2egvA-4f4oC:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IDW_B_017B401_1
(PROTEASE)		 4f4o HAPTOGLOBIN
(Sus
scrofa) 		5 / 11 LEU C 138
VAL C 177
ILE C 158
ILE C 121
ILE C 191
 None
 0.91A 2idwA-4f4oC:
undetectable		 2idwA-4f4oC:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDB_A_NPSA1591_1
(SERUM ALBUMIN)		 4f4o HAPTOGLOBIN
(Sus
scrofa) 		4 / 8 ILE C 336
LEU C 139
ARG C 332
GLY C 314
 None
 0.85A 2vdbA-4f4oC:
undetectable		 2vdbA-4f4oC:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOB_C_RFPC2002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4f4o HAPTOGLOBIN
(Sus
scrofa) 		5 / 12 PHE C 318
THR C 291
ASN C 144
GLY C 129
LEU C 147
 None
 1.28A 3aobC-4f4oC:
undetectable		 3aobC-4f4oC:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKQ_A_ROCA100_2
(PROTEASE)		 4f4o HAPTOGLOBIN
(Sus
scrofa) 		5 / 9 LEU C 138
VAL C 177
ILE C 158
ILE C 121
ILE C 191
 None
 1.05A 3ekqB-4f4oC:
undetectable		 3ekqB-4f4oC:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL0_A_1UNA201_2
(PROTEASE)		 4f4o HAPTOGLOBIN
(Sus
scrofa) 		5 / 9 LEU C 138
VAL C 177
ILE C 158
ILE C 121
ILE C 191
 None
 1.03A 3el0B-4f4oC:
undetectable		 3el0B-4f4oC:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_V_DR7V100_1
(PROTEASE)		 4f4o HAPTOGLOBIN
(Sus
scrofa) 		5 / 11 GLY C 129
ALA C 130
ILE C 133
VAL C 177
ILE C 191
 None
 0.92A 3em4U-4f4oC:
undetectable		 3em4U-4f4oC:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MWS_B_017B201_2
(HIV-1 PROTEASE)		 4f4o HAPTOGLOBIN
(Sus
scrofa) 		5 / 12 LEU C 138
VAL C 177
ILE C 158
ILE C 121
ILE C 191
 None
 1.01A 3mwsB-4f4oC:
undetectable		 3mwsB-4f4oC:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_A_PFLA319_1
(GLR4197 PROTEIN)		 4f4o HAPTOGLOBIN
(Sus
scrofa) 		4 / 7 LEU C 208
THR C 343
ILE C 344
ASN C 134
 None
 0.94A 3p50A-4f4oC:
undetectable		 3p50A-4f4oC:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_B_PFLB319_1
(GLR4197 PROTEIN)		 4f4o HAPTOGLOBIN
(Sus
scrofa) 		4 / 7 LEU C 208
THR C 343
ILE C 344
ASN C 134
 None
 0.93A 3p50B-4f4oC:
undetectable		 3p50B-4f4oC:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_C_PFLC319_1
(GLR4197 PROTEIN)		 4f4o HAPTOGLOBIN
(Sus
scrofa) 		4 / 7 LEU C 208
THR C 343
ILE C 344
ASN C 134
 None
 0.93A 3p50C-4f4oC:
undetectable		 3p50C-4f4oC:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_D_PFLD320_1
(GLR4197 PROTEIN)		 4f4o HAPTOGLOBIN
(Sus
scrofa) 		4 / 7 LEU C 208
THR C 343
ILE C 344
ASN C 134
 None
 0.93A 3p50D-4f4oC:
undetectable		 3p50D-4f4oC:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_E_PFLE319_1
(GLR4197 PROTEIN)		 4f4o HAPTOGLOBIN
(Sus
scrofa) 		4 / 7 LEU C 208
THR C 343
ILE C 344
ASN C 134
 None
 0.93A 3p50E-4f4oC:
undetectable		 3p50E-4f4oC:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_B_ROCB801_1
(PROTEASE)		 4f4o HAPTOGLOBIN
(Sus
scrofa) 		5 / 12 GLY C 129
ALA C 130
ILE C 133
VAL C 177
ILE C 191
 None
 0.94A 3tkgA-4f4oC:
undetectable		 3tkgA-4f4oC:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQB_B_017B101_1
(ASPARTYL PROTEASE)		 4f4o HAPTOGLOBIN
(Sus
scrofa) 		5 / 12 LEU C 138
VAL C 177
ILE C 158
ILE C 121
ILE C 191
 None
 0.94A 4dqbA-4f4oC:
undetectable		 4dqbA-4f4oC:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_C_ACTC506_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4f4o HAPTOGLOBIN
(Sus
scrofa) 		4 / 5 ARG C 146
ILE C 158
HIS C 149
GLY C 148
 NAG  C1004 ( 4.5A)
None
None
None
 1.12A 4e7cC-4f4oC:
undetectable		 4e7cC-4f4oC:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F3T_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 4f4o HAPTOGLOBIN
(Sus
scrofa) 		4 / 4 PHE C 300
VAL C 222
ALA C 301
PHE C 114
 None
 1.49A 4f3tA-4f4oC:
undetectable		 4f3tA-4f4oC:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_2
(HIV-1 PROTEASE)		 4f4o HAPTOGLOBIN
(Sus
scrofa) 		5 / 12 LEU C 138
VAL C 177
ILE C 158
ILE C 121
ILE C 191
 None
 1.01A 4jecB-4f4oC:
undetectable		 4jecB-4f4oC:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_D_017D101_1
(PROTEASE)		 4f4o HAPTOGLOBIN
(Sus
scrofa) 		5 / 11 LEU C 138
VAL C 177
ILE C 158
ILE C 121
ILE C 191
 None
 0.90A 4njtC-4f4oC:
undetectable		 4njtC-4f4oC:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4f4o HAPTOGLOBIN
(Sus
scrofa) 		5 / 9 THR C 141
ALA C 130
THR C 131
ALA C 118
GLY C 189
 None
 1.19A 4qwuK-4f4oC:
undetectable
4qwuL-4f4oC:
undetectable		 4qwuK-4f4oC:
20.29
4qwuL-4f4oC:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 4f4o HAPTOGLOBIN
(Sus
scrofa) 		4 / 4 PHE C 300
VAL C 222
ALA C 301
PHE C 114
 None
 1.43A 4w5qA-4f4oC:
undetectable		 4w5qA-4f4oC:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5R_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 4f4o HAPTOGLOBIN
(Sus
scrofa) 		4 / 4 PHE C 300
VAL C 222
ALA C 301
PHE C 114
 None
 1.50A 4w5rA-4f4oC:
undetectable		 4w5rA-4f4oC:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X61_A_SAMA701_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 4f4o HAPTOGLOBIN
(Sus
scrofa) 		5 / 12 LEU C 108
GLY C 224
GLY C 226
ASN C 228
LEU C 237
 None
 1.20A 4x61A-4f4oC:
undetectable		 4x61A-4f4oC:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUD_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 4f4o HAPTOGLOBIN
(Sus
scrofa) 		5 / 12 GLY C 314
TYR C 213
ILE C 315
SER C 298
GLN C 117
 None
 1.46A 4xudA-4f4oC:
undetectable		 4xudA-4f4oC:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 4f4o HAPTOGLOBIN
(Sus
scrofa) 		4 / 4 PHE C 300
VAL C 222
ALA C 301
PHE C 114
 None
 1.46A 4z4gA-4f4oC:
undetectable		 4z4gA-4f4oC:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IFU_B_GBMB801_1
(PROLINE--TRNA LIGASE)		 4f4o HAPTOGLOBIN
(Sus
scrofa) 		5 / 9 TYR C 330
LEU C 242
THR C 291
ILE C 103
GLY C 224
 None
 1.33A 5ifuB-4f4oC:
undetectable		 5ifuB-4f4oC:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KI6_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 4f4o HAPTOGLOBIN
(Sus
scrofa) 		4 / 4 PHE C 300
VAL C 222
ALA C 301
PHE C 114
 None
 1.47A 5ki6A-4f4oC:
undetectable		 5ki6A-4f4oC:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_G_SAMG501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 4f4o HAPTOGLOBIN
(Sus
scrofa) 		5 / 11 LEU C 139
GLY C 297
GLY C 129
LEU C 190
THR C 141
 None
 0.99A 5o96G-4f4oC:
undetectable		 5o96G-4f4oC:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_H_SAMH501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 4f4o HAPTOGLOBIN
(Sus
scrofa) 		5 / 10 LEU C 139
GLY C 297
GLY C 129
LEU C 190
THR C 141
 None
 0.97A 5o96G-4f4oC:
undetectable
5o96H-4f4oC:
undetectable		 5o96G-4f4oC:
21.47
5o96H-4f4oC:
21.47