SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4f4w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4001_1
(SERUM ALBUMIN)		 4f4w DNA POLYMERASE IV
(Sulfolobus
acidocaldarius;
Sulfolobus
solfataricus) 		4 / 5 ARG A 127
LYS A 128
ALA A 126
GLY A 122
 None
 1.12A 1e7cA-4f4wA:
undetectable		 1e7cA-4f4wA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_D_ESTD352_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 4f4w DNA POLYMERASE IV
(Sulfolobus
acidocaldarius;
Sulfolobus
solfataricus) 		4 / 6 VAL A 166
GLY A 165
LEU A 164
GLU A 124
 None
 1.01A 1fduD-4f4wA:
undetectable		 1fduD-4f4wA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FXV_B_PNNB1001_0
(PENICILLIN ACYLASE)		 4f4w DNA POLYMERASE IV
(Sulfolobus
acidocaldarius;
Sulfolobus
solfataricus) 		4 / 7 SER A 316
PHE A 267
ALA A 312
PHE A 338
 None
 1.17A 1fxvA-4f4wA:
undetectable
1fxvB-4f4wA:
2.1		 1fxvA-4f4wA:
21.98
1fxvB-4f4wA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUI_B_AB1B100_2
(PROTEASE)		 4f4w DNA POLYMERASE IV
(Sulfolobus
acidocaldarius;
Sulfolobus
solfataricus) 		5 / 12 ALA A  96
ASP A  97
ASP A 110
GLY A 122
VAL A   6
 None
 0.85A 1muiB-4f4wA:
undetectable		 1muiB-4f4wA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RI4_A_SAMA299_0
(MRNA CAPPING ENZYME)		 4f4w DNA POLYMERASE IV
(Sulfolobus
acidocaldarius;
Sulfolobus
solfataricus) 		5 / 12 GLY A 165
GLY A 144
ILE A 167
ALA A 146
SER A 159
 None
 1.13A 1ri4A-4f4wA:
undetectable		 1ri4A-4f4wA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T88_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 4f4w DNA POLYMERASE IV
(Sulfolobus
acidocaldarius;
Sulfolobus
solfataricus) 		4 / 7 LEU A 164
VAL A 143
GLY A 144
VAL A 111
 None
 0.80A 1t88A-4f4wA:
undetectable		 1t88A-4f4wA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1O_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 4f4w DNA POLYMERASE IV
(Sulfolobus
acidocaldarius;
Sulfolobus
solfataricus) 		4 / 8 LEU A 164
VAL A 143
GLY A 144
VAL A 111
 None
 0.81A 2a1oA-4f4wA:
undetectable		 2a1oA-4f4wA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4S_A_AB1A400_1
(PROTEASE)		 4f4w DNA POLYMERASE IV
(Sulfolobus
acidocaldarius;
Sulfolobus
solfataricus) 		5 / 12 ALA A  96
ASP A  97
ASP A 110
GLY A 122
VAL A   6
 None
 0.64A 2o4sA-4f4wA:
undetectable		 2o4sA-4f4wA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1357_1
(PROSTAGLANDIN
REDUCTASE 2)		 4f4w DNA POLYMERASE IV
(Sulfolobus
acidocaldarius;
Sulfolobus
solfataricus) 		4 / 6 LEU A 151
ASN A 148
LYS A   1
ASP A 110
 None
 1.33A 2w98A-4f4wA:
undetectable
2w98B-4f4wA:
undetectable		 2w98A-4f4wA:
23.06
2w98B-4f4wA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_B_486B1_2
(GLUCOCORTICOID
RECEPTOR)		 4f4w DNA POLYMERASE IV
(Sulfolobus
acidocaldarius;
Sulfolobus
solfataricus) 		5 / 12 GLY A 144
GLY A 165
VAL A 166
MET A  89
ILE A 123
 None
 1.28A 3h52B-4f4wA:
undetectable		 3h52B-4f4wA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_A_CHDA424_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4f4w DNA POLYMERASE IV
(Sulfolobus
acidocaldarius;
Sulfolobus
solfataricus) 		4 / 8 ARG A 280
ARG A 243
SER A 298
GLY A 247
 None
 1.11A 3hcrA-4f4wA:
undetectable		 3hcrA-4f4wA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_B_CHDB924_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4f4w DNA POLYMERASE IV
(Sulfolobus
acidocaldarius;
Sulfolobus
solfataricus) 		4 / 7 ARG A 280
ARG A 243
SER A 298
GLY A 247
 None
 0.93A 3hcrB-4f4wA:
undetectable		 3hcrB-4f4wA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_I_P77I203_1
(PROTEIN S100-A4)		 4f4w DNA POLYMERASE IV
(Sulfolobus
acidocaldarius;
Sulfolobus
solfataricus) 		5 / 10 LEU A  91
SER A  85
PHE A  84
SER A 103
PHE A  11
 None
None
None
CA  A 403 ( 4.6A)
None
 1.49A 3m0wA-4f4wA:
undetectable
3m0wB-4f4wA:
undetectable
3m0wI-4f4wA:
undetectable
3m0wJ-4f4wA:
undetectable		 3m0wA-4f4wA:
16.41
3m0wB-4f4wA:
16.41
3m0wI-4f4wA:
16.41
3m0wJ-4f4wA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_D_017D200_1
(HIV-1 PROTEASE)		 4f4w DNA POLYMERASE IV
(Sulfolobus
acidocaldarius;
Sulfolobus
solfataricus) 		5 / 10 ALA A  96
ASP A  97
ASP A 110
GLY A 122
VAL A   6
 None
 0.81A 3oxwC-4f4wA:
undetectable		 3oxwC-4f4wA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5J_A_08HA1_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 4f4w DNA POLYMERASE IV
(Sulfolobus
acidocaldarius;
Sulfolobus
solfataricus) 		5 / 7 PRO A 185
LEU A 179
LEU A 176
ASN A 148
ILE A 150
 None
 1.40A 3u5jA-4f4wA:
undetectable		 3u5jA-4f4wA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UBO_B_ADNB353_2
(ADENOSINE KINASE)		 4f4w DNA POLYMERASE IV
(Sulfolobus
acidocaldarius;
Sulfolobus
solfataricus) 		4 / 5 SER A 308
ILE A 285
GLY A 306
PRO A 282
 None
 1.00A 3uboB-4f4wA:
undetectable		 3uboB-4f4wA:
25.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C66_A_H4CA1168_0
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 4f4w DNA POLYMERASE IV
(Sulfolobus
acidocaldarius;
Sulfolobus
solfataricus) 		5 / 9 PRO A 185
LEU A 179
LEU A 176
ASN A 148
ILE A 150
 None
 1.44A 4c66A-4f4wA:
undetectable		 4c66A-4f4wA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQH_B_017B101_1
(WILD-TYPE HIV-1
PROTEASE DIMER)		 4f4w DNA POLYMERASE IV
(Sulfolobus
acidocaldarius;
Sulfolobus
solfataricus) 		5 / 11 LEU A  92
ALA A  96
ASP A 110
GLY A 122
VAL A   6
 None
 0.95A 4dqhA-4f4wA:
undetectable		 4dqhA-4f4wA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E0F_A_RBFA301_1
(RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA)		 4f4w DNA POLYMERASE IV
(Sulfolobus
acidocaldarius;
Sulfolobus
solfataricus) 		5 / 11 VAL A 336
GLU A 315
ALA A 312
HIS A 286
VAL A 287
 None
 1.22A 4e0fA-4f4wA:
undetectable		 4e0fA-4f4wA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J03_A_FVSA603_1
(BIFUNCTIONAL EPOXIDE
HYDROLASE 2)		 4f4w DNA POLYMERASE IV
(Sulfolobus
acidocaldarius;
Sulfolobus
solfataricus) 		5 / 12 ILE A 167
LEU A 195
LEU A 214
TYR A 225
LEU A 179
 None
 1.12A 4j03A-4f4wA:
undetectable		 4j03A-4f4wA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCU_A_SAMA603_0
(CYSTATHIONINE
BETA-SYNTHASE)		 4f4w DNA POLYMERASE IV
(Sulfolobus
acidocaldarius;
Sulfolobus
solfataricus) 		4 / 7 PHE A  11
ASP A   9
GLN A  14
ILE A 133
 None
 0.97A 4pcuA-4f4wA:
undetectable		 4pcuA-4f4wA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y1D_D_DVAD5_0
(CYCLIC HEXAPEPTIDE
CYC[NDPOPPKID]
INTEGRASE)		 4f4w DNA POLYMERASE IV
(Sulfolobus
acidocaldarius;
Sulfolobus
solfataricus) 		3 / 3 GLU A 178
LYS A 202
ASN A 177
 None
 1.06A 4y1dA-4f4wA:
undetectable
4y1dD-4f4wA:
undetectable		 4y1dA-4f4wA:
18.33
4y1dD-4f4wA:
1.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_B_SAMB501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)		 4f4w DNA POLYMERASE IV
(Sulfolobus
acidocaldarius;
Sulfolobus
solfataricus) 		5 / 12 ALA A 146
PRO A 147
LYS A 153
ILE A 154
ASP A   7
 None
None
None
None
CA  A 403 (-2.7A)
 1.25A 5wwsB-4f4wA:
undetectable		 5wwsB-4f4wA:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y1Y_A_HNQA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 4f4w DNA POLYMERASE IV
(Sulfolobus
acidocaldarius;
Sulfolobus
solfataricus) 		4 / 8 PRO A 185
LEU A 176
ASN A 148
ILE A 150
 None
 0.92A 5y1yA-4f4wA:
undetectable		 5y1yA-4f4wA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YK2_A_ERYA501_0
(PROBABLE CONSERVED
ATP-BINDING PROTEIN
ABC TRANSPORTER)		 4f4w DNA POLYMERASE IV
(Sulfolobus
acidocaldarius;
Sulfolobus
solfataricus) 		5 / 11 GLU A 120
GLY A 144
ALA A 146
PRO A 147
ILE A 167
 None
 1.12A 5yk2A-4f4wA:
2.0		 5yk2A-4f4wA:
22.39