SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4f4z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7R_A_NCTA440_1
(CYTOCHROME P450-CAM)		 4f4z DNA POLYMERASE IV
(Sulfolobus
acidocaldarius;
Sulfolobus
solfataricus) 		4 / 7 VAL B 183
VAL B 171
ASP B 231
ILE B 175
 None
 0.96A 1p7rA-4f4zB:
undetectable		 1p7rA-4f4zB:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_B_9CRB502_1
(CYTOCHROME P450 2C8)		 4f4z DNA POLYMERASE IV
(Sulfolobus
acidocaldarius;
Sulfolobus
solfataricus) 		5 / 10 ILE B 279
ASN B 270
ASN B 309
VAL B 276
ILE B 269
 None
 1.25A 2nnhB-4f4zB:
undetectable		 2nnhB-4f4zB:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBM_A_CAMA517_0
(CYTOCHROME P450-CAM)		 4f4z DNA POLYMERASE IV
(Sulfolobus
acidocaldarius;
Sulfolobus
solfataricus) 		4 / 8 VAL B 183
VAL B 171
ASP B 231
ILE B 175
 None
 0.97A 2qbmA-4f4zB:
undetectable		 2qbmA-4f4zB:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W1B_A_DXCA2034_0
(ACRIFLAVIN
RESISTANCE PROTEIN B)		 4f4z DNA POLYMERASE IV
(Sulfolobus
acidocaldarius;
Sulfolobus
solfataricus) 		3 / 3 PHE B 150
SER B 227
LEU B 225
 None
 0.81A 2w1bA-4f4zB:
3.6		 2w1bA-4f4zB:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GP0_A_NILA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)		 4f4z DNA POLYMERASE IV
(Sulfolobus
acidocaldarius;
Sulfolobus
solfataricus) 		4 / 7 LYS B 129
LEU B 126
LEU B 109
ILE B 166
 None
 0.90A 3gp0A-4f4zB:
undetectable		 3gp0A-4f4zB:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O0M_A_ACTA146_0
(HIT FAMILY PROTEIN)		 4f4z DNA POLYMERASE IV
(Sulfolobus
acidocaldarius;
Sulfolobus
solfataricus) 		4 / 4 ASP B 167
GLU B 169
GLU B 170
ARG B 173
 None
 1.17A 3o0mA-4f4zB:
0.4		 3o0mA-4f4zB:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_B_DM2B1104_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4f4z DNA POLYMERASE IV
(Sulfolobus
acidocaldarius;
Sulfolobus
solfataricus) 		4 / 8 GLN B  82
ILE B 138
VAL B 140
PHE B   8
 None
 0.83A 4dx7B-4f4zB:
4.5		 4dx7B-4f4zB:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6V_E_RBFE201_1
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT B
NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT E)		 4f4z DNA POLYMERASE IV
(Sulfolobus
acidocaldarius;
Sulfolobus
solfataricus) 		4 / 5 VAL B 171
GLU B 170
VAL B 165
LYS B 164
 None
 1.30A 4p6vB-4f4zB:
undetectable
4p6vE-4f4zB:
undetectable		 4p6vB-4f4zB:
20.67
4p6vE-4f4zB:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_A_BQ1A1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 4f4z DNA POLYMERASE IV
(Sulfolobus
acidocaldarius;
Sulfolobus
solfataricus) 		3 / 3 GLU B  49
ALA B  50
PHE B  53
 None
 0.61A 4v1fA-4f4zB:
undetectable		 4v1fA-4f4zB:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_C_BQ1C1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 4f4z DNA POLYMERASE IV
(Sulfolobus
acidocaldarius;
Sulfolobus
solfataricus) 		3 / 3 GLU B  49
ALA B  50
PHE B  53
 None
 0.64A 4v1fC-4f4zB:
undetectable		 4v1fC-4f4zB:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_B_ADNB401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)		 4f4z DNA POLYMERASE IV
(Sulfolobus
acidocaldarius;
Sulfolobus
solfataricus) 		5 / 12 ILE B 153
VAL B 171
ASP B 156
ALA B 155
PRO B 184
 None
None
None
None
CA  B 402 ( 4.8A)
 1.03A 6bq4B-4f4zB:
undetectable		 6bq4B-4f4zB:
12.61