SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4f52'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AGM_A_ACRA496_2
(GLUCOAMYLASE-471)
4f52 GLOMULIN
(Homo
sapiens)
4 / 5 SER E 119
GLU E 108
LEU E 102
TRP E  63
None
1.47A 1agmA-4f52E:
undetectable
1agmA-4f52E:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM9_A_9CRA201_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
4f52 E3 UBIQUITIN-PROTEIN
LIGASE RBX1
GLOMULIN

(Homo
sapiens)
3 / 3 GLN E 427
ILE B  37
HIS E 413
None
0.71A 1fm9A-4f52E:
undetectable
1fm9A-4f52E:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K74_A_9CRA463_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
4f52 E3 UBIQUITIN-PROTEIN
LIGASE RBX1
GLOMULIN

(Homo
sapiens)
3 / 3 GLN E 427
ILE B  37
HIS E 413
None
0.71A 1k74A-4f52E:
undetectable
1k74A-4f52E:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P9G_A_ACTA42_0
(EAFP 2)
4f52 E3 UBIQUITIN-PROTEIN
LIGASE RBX1
GLOMULIN

(Homo
sapiens;
Homo
sapiens)
3 / 3 CYH B  45
ARG E 479
CYH B  53
ZN  B 201 (-2.2A)
None
ZN  B 203 (-2.5A)
1.09A 1p9gA-4f52B:
undetectable
1p9gA-4f52B:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P9G_A_ACTA42_0
(EAFP 2)
4f52 E3 UBIQUITIN-PROTEIN
LIGASE RBX1
GLOMULIN

(Homo
sapiens;
Homo
sapiens)
3 / 3 CYH B  45
ARG E 479
CYH B  83
ZN  B 201 (-2.2A)
None
ZN  B 201 (-2.4A)
1.34A 1p9gA-4f52B:
undetectable
1p9gA-4f52B:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLS_A_C2FA266_0
(THYMIDYLATE SYNTHASE)
4f52 GLOMULIN
(Homo
sapiens)
5 / 12 SER E 114
ILE E 118
LEU E 126
LEU E 173
GLY E 172
None
1.13A 1tlsA-4f52E:
undetectable
1tlsA-4f52E:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLS_B_C2FB266_0
(THYMIDYLATE SYNTHASE)
4f52 GLOMULIN
(Homo
sapiens)
5 / 12 SER E 114
ILE E 118
LEU E 126
LEU E 173
GLY E 172
None
1.15A 1tlsB-4f52E:
undetectable
1tlsB-4f52E:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TMX_A_BEZA881_0
(HYDROXYQUINOL
1,2-DIOXYGENASE)
4f52 CULLIN-1
(Homo
sapiens)
5 / 11 LEU A 540
ASP A 510
TYR A 570
HIS A 574
VAL A 513
None
1.35A 1tmxA-4f52A:
undetectable
1tmxA-4f52A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_A_CLMA1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)
4f52 GLOMULIN
(Homo
sapiens)
4 / 7 GLY E 443
PRO E 444
THR E 496
GLY E 493
None
0.85A 1usqA-4f52E:
undetectable
1usqA-4f52E:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_B_ACTB294_0
(GLYCINE
N-METHYLTRANSFERASE)
4f52 CULLIN-1
(Homo
sapiens)
4 / 6 ALA A 484
GLU A 485
ILE A 489
LEU A 446
None
0.86A 1xvaA-4f52A:
undetectable
1xvaB-4f52A:
undetectable
1xvaA-4f52A:
22.12
1xvaB-4f52A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ1_A_HLTA2001_1
(FERRITIN LIGHT CHAIN)
4f52 CULLIN-1
(Homo
sapiens)
4 / 4 LEU A 559
SER A 562
TYR A 563
LEU A 555
None
0.94A 1xz1A-4f52A:
undetectable
1xz1A-4f52A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ3_A_ICFA201_1
(FERRITIN LIGHT CHAIN)
4f52 CULLIN-1
(Homo
sapiens)
4 / 4 LEU A 559
SER A 562
TYR A 563
LEU A 555
None
0.94A 1xz3A-4f52A:
undetectable
1xz3A-4f52A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3478_1
(NEURAMINIDASE)
4f52 CULLIN-1
(Homo
sapiens)
4 / 8 ASP A 427
SER A 479
ASN A 478
GLN A 477
None
1.13A 2cmlC-4f52A:
undetectable
2cmlC-4f52A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E7F_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)
4f52 GLOMULIN
(Homo
sapiens)
5 / 12 GLU E  38
ILE E  89
LEU E  93
GLY E  33
ILE E  37
None
1.05A 2e7fA-4f52E:
undetectable
2e7fA-4f52E:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E7F_B_C2FB4000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)
4f52 GLOMULIN
(Homo
sapiens)
5 / 12 GLU E  38
ILE E  89
LEU E  93
GLY E  33
ILE E  37
None
1.08A 2e7fB-4f52E:
undetectable
2e7fB-4f52E:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FT9_A_CHDA131_0
(FATTY ACID-BINDING
PROTEIN 2, LIVER)
4f52 CULLIN-1
(Homo
sapiens)
5 / 11 LEU A 643
LEU A 649
ILE A 631
THR A 629
LEU A 590
None
1.31A 2ft9A-4f52A:
undetectable
2ft9A-4f52A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA701_0
(FERROCHELATASE)
4f52 CULLIN-1
GLOMULIN

(Homo
sapiens;
Homo
sapiens)
5 / 12 LEU A 531
ILE A 537
SER A 528
HIS A 524
LEU E 555
None
1.18A 2hrcA-4f52A:
undetectable
2hrcA-4f52A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_A_CLMA1144_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)
4f52 GLOMULIN
(Homo
sapiens)
4 / 7 GLY E 443
PRO E 444
THR E 496
GLY E 493
None
0.85A 2jklA-4f52E:
undetectable
2jklA-4f52E:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_C_CLMC1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)
4f52 GLOMULIN
(Homo
sapiens)
4 / 7 GLY E 443
PRO E 444
THR E 496
GLY E 493
None
0.85A 2jklC-4f52E:
undetectable
2jklC-4f52E:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_D_CLMD1145_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)
4f52 GLOMULIN
(Homo
sapiens)
4 / 7 GLY E 443
PRO E 444
THR E 496
GLY E 493
None
0.85A 2jklD-4f52E:
undetectable
2jklD-4f52E:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_F_CLMF1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)
4f52 GLOMULIN
(Homo
sapiens)
4 / 7 GLY E 443
PRO E 444
THR E 496
GLY E 493
None
0.86A 2jklF-4f52E:
undetectable
2jklF-4f52E:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OGY_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)
4f52 GLOMULIN
(Homo
sapiens)
5 / 12 GLU E  38
ILE E  89
LEU E  93
GLY E  33
ILE E  37
None
1.08A 2ogyA-4f52E:
undetectable
2ogyA-4f52E:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OGY_B_C2FB4000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)
4f52 GLOMULIN
(Homo
sapiens)
5 / 12 GLU E  38
ILE E  89
LEU E  93
GLY E  33
ILE E  37
None
1.08A 2ogyB-4f52E:
undetectable
2ogyB-4f52E:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q2H_B_ACTB501_0
(SECRETION CHAPERONE,
PHAGE-DISPLAY
DERIVED PEPTIDE)
4f52 CULLIN-1
(Homo
sapiens)
3 / 3 ARG A 577
SER A 541
TYR A 570
None
1.01A 2q2hA-4f52A:
undetectable
2q2hB-4f52A:
undetectable
2q2hA-4f52A:
18.09
2q2hB-4f52A:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_H_CPFH1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)
4f52 GLOMULIN
(Homo
sapiens)
3 / 3 ARG E 470
GLU E 417
SER E 516
None
0.88A 2xctD-4f52E:
4.8
2xctD-4f52E:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_B_VDYB6178_1
(VITAMIN D
HYDROXYLASE)
4f52 GLOMULIN
(Homo
sapiens)
5 / 12 PRO E 457
THR E 462
LEU E 456
ILE E 568
VAL E 575
None
1.36A 3a51B-4f52E:
2.8
3a51B-4f52E:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_B_VDYB6178_1
(VITAMIN D
HYDROXYLASE)
4f52 GLOMULIN
(Homo
sapiens)
5 / 12 PRO E 457
THR E 462
LEU E 456
VAL E 575
LEU E 475
None
1.40A 3a51B-4f52E:
2.8
3a51B-4f52E:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_A_ECLA600_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)
4f52 CULLIN-1
(Homo
sapiens)
4 / 8 LEU A 668
THR A 667
THR A 629
ILE A 610
None
0.77A 3jusA-4f52A:
undetectable
3jusA-4f52A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_A_ECNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)
4f52 CULLIN-1
(Homo
sapiens)
4 / 8 LEU A 668
THR A 667
THR A 629
ILE A 610
None
0.77A 3jusA-4f52A:
undetectable
3jusA-4f52A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N23_C_OBNC1_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)
4f52 CULLIN-1
E3 UBIQUITIN-PROTEIN
LIGASE RBX1

(Homo
sapiens)
5 / 11 LEU A 540
VAL B  30
ALA B  29
PHE A 566
PHE A 569
None
1.43A 3n23C-4f52A:
undetectable
3n23C-4f52A:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QG2_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)
4f52 GLOMULIN
(Homo
sapiens)
5 / 11 ILE E 143
ALA E 146
SER E 215
ILE E 244
LEU E 208
None
1.32A 3qg2B-4f52E:
undetectable
3qg2B-4f52E:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAV_A_RAVA183_1
(FERRITIN LIGHT CHAIN)
4f52 CULLIN-1
(Homo
sapiens)
4 / 6 LEU A 559
SER A 562
TYR A 563
LEU A 555
None
0.92A 3ravA-4f52A:
undetectable
3ravA-4f52A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)
4f52 CULLIN-1
(Homo
sapiens)
4 / 6 LEU A 559
SER A 562
TYR A 563
LEU A 555
None
0.91A 3rd0A-4f52A:
undetectable
3rd0A-4f52A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U6T_A_KANA4699_1
(RIBOSOME
INACTIVATING PROTEIN)
4f52 GLOMULIN
(Homo
sapiens)
5 / 10 TYR E 141
ILE E 143
GLU E 200
ILE E 133
ALA E 146
None
1.35A 3u6tA-4f52E:
undetectable
3u6tA-4f52E:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D32_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)
4f52 GLOMULIN
(Homo
sapiens)
4 / 8 PHE E 419
GLU E 417
SER E 411
VAL E 369
None
1.39A 4d32A-4f52E:
undetectable
4d32B-4f52E:
undetectable
4d32A-4f52E:
21.28
4d32B-4f52E:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M51_A_BEZA501_0
(AMIDOHYDROLASE
FAMILY PROTEIN)
4f52 GLOMULIN
(Homo
sapiens)
4 / 6 ILE E  57
ILE E  49
PHE E  29
LEU E   6
None
0.96A 4m51A-4f52E:
undetectable
4m51A-4f52E:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_A_C2FA3000_0
(DIHYDROPTEROATE
SYNTHASE DHPS)
4f52 GLOMULIN
(Homo
sapiens)
5 / 12 GLU E  38
ILE E  89
LEU E  93
GLY E  33
ILE E  37
None
0.91A 4o1eA-4f52E:
undetectable
4o1eA-4f52E:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_B_C2FB4000_0
(DIHYDROPTEROATE
SYNTHASE DHPS)
4f52 GLOMULIN
(Homo
sapiens)
5 / 12 GLU E  38
ILE E  89
LEU E  93
GLY E  33
ILE E  37
None
0.89A 4o1eB-4f52E:
undetectable
4o1eB-4f52E:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_A_NOVA2000_1
(DNA GYRASE SUBUNIT B)
4f52 GLOMULIN
(Homo
sapiens)
5 / 12 ASP E 235
ILE E 298
ASP E 301
GLN E 302
ILE E 245
None
1.25A 4uroA-4f52E:
undetectable
4uroA-4f52E:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_B_NOVB2000_1
(DNA GYRASE SUBUNIT B)
4f52 GLOMULIN
(Homo
sapiens)
5 / 12 ASP E 235
ILE E 298
ASP E 301
GLN E 302
ILE E 245
None
1.29A 4uroB-4f52E:
undetectable
4uroB-4f52E:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_W_BEZW801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)
4f52 GLOMULIN
(Homo
sapiens)
4 / 5 PHE E  29
ILE E  48
GLY E  62
ILE E  10
None
0.84A 5dzkB-4f52E:
undetectable
5dzkI-4f52E:
1.9
5dzkW-4f52E:
undetectable
5dzkB-4f52E:
17.53
5dzkI-4f52E:
17.94
5dzkW-4f52E:
4.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JKW_A_TESA601_1
(AROMATASE)
4f52 GLOMULIN
(Homo
sapiens)
5 / 11 ILE E 501
PHE E 505
ILE E 579
VAL E 453
LEU E 475
None
1.34A 5jkwA-4f52E:
undetectable
5jkwA-4f52E:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIX_B_OQRB302_0
(SULFOTRANSFERASE)
4f52 E3 UBIQUITIN-PROTEIN
LIGASE RBX1
GLOMULIN

(Homo
sapiens;
Homo
sapiens)
5 / 10 MET E 472
ILE E 568
VAL E 575
LEU E 578
GLU B  55
None
1.46A 5tixB-4f52E:
undetectable
5tixB-4f52E:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XOO_B_ADNB503_1
(GLYCOSAMINOGLYCAN
XYLOSYLKINASE)
4f52 GLOMULIN
(Homo
sapiens)
4 / 5 LEU E 478
VAL E 575
GLU E 576
LEU E 506
None
1.03A 5xooB-4f52E:
undetectable
5xooB-4f52E:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_B_9CRB501_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
4f52 E3 UBIQUITIN-PROTEIN
LIGASE RBX1
GLOMULIN

(Homo
sapiens)
3 / 3 GLN E 427
ILE B  37
HIS E 413
None
0.70A 5z12B-4f52E:
undetectable
5z12B-4f52E:
9.62