SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4f53'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_C_DVAC6_0
(GRAMICIDIN A)		 4f53 SUSD HOMOLOG
(Bacteroides
ovatus) 		3 / 3 ALA A 202
VAL A  48
TRP A  45
 None
 0.88A 1av2C-4f53A:
undetectable
1av2D-4f53A:
undetectable		 1av2C-4f53A:
2.62
1av2D-4f53A:
2.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_D_THAD4_2
(LIVER
CARBOXYLESTERASE I)		 4f53 SUSD HOMOLOG
(Bacteroides
ovatus) 		3 / 3 PHE A 216
LEU A 138
MET A 179
 None
 0.74A 1mx1D-4f53A:
undetectable		 1mx1D-4f53A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT2_A_SAMA301_0
(FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN)		 4f53 SUSD HOMOLOG
(Bacteroides
ovatus) 		5 / 12 TYR A 262
GLY A 260
ALA A 357
SER A 358
ALA A 212
 None
 1.17A 1nt2A-4f53A:
undetectable		 1nt2A-4f53A:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT6_A_DVAA6_0
(GRAMICIDIN C)		 4f53 SUSD HOMOLOG
(Bacteroides
ovatus) 		3 / 3 ALA A 202
VAL A  48
TRP A  45
 None
 0.88A 1nt6A-4f53A:
undetectable		 1nt6A-4f53A:
2.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT6_B_DVAB6_0
(GRAMICIDIN C)		 4f53 SUSD HOMOLOG
(Bacteroides
ovatus) 		3 / 3 ALA A 202
VAL A  48
TRP A  45
 None
 0.88A 1nt6B-4f53A:
undetectable		 1nt6B-4f53A:
2.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_A_SAMA801_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 4f53 SUSD HOMOLOG
(Bacteroides
ovatus) 		4 / 6 ARG A 223
ASP A  71
ASN A 269
GLU A 464
 None
 1.15A 1rjdA-4f53A:
undetectable		 1rjdA-4f53A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_B_SAMB802_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 4f53 SUSD HOMOLOG
(Bacteroides
ovatus) 		4 / 6 ARG A 223
ASP A  71
ASN A 269
GLU A 464
 None
 1.18A 1rjdB-4f53A:
undetectable		 1rjdB-4f53A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_C_SAMC803_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 4f53 SUSD HOMOLOG
(Bacteroides
ovatus) 		4 / 6 ARG A 223
ASP A  71
ASN A 269
GLU A 464
 None
 1.19A 1rjdC-4f53A:
undetectable		 1rjdC-4f53A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_A_VIBA502_1
(YKOF)		 4f53 SUSD HOMOLOG
(Bacteroides
ovatus) 		4 / 6 PHE A 216
ALA A 217
LEU A 220
ILE A 141
 None
 0.98A 1sbrA-4f53A:
undetectable
1sbrB-4f53A:
undetectable		 1sbrA-4f53A:
17.07
1sbrB-4f53A:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UUJ_B_ACTB1077_0
(PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE IB
ALPHA SUBUNIT)		 4f53 SUSD HOMOLOG
(Bacteroides
ovatus) 		3 / 3 ARG A 140
TYR A 120
LYS A 124
 ACT  A 601 (-3.2A)
None
ACT  A 601 (-3.1A)
 0.70A 1uujB-4f53A:
0.0		 1uujB-4f53A:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_A_NCTA1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4f53 SUSD HOMOLOG
(Bacteroides
ovatus) 		4 / 8 TYR A 206
THR A 258
TYR A 262
LEU A 388
 None
None
None
CA  A 603 ( 4.7A)
 1.41A 1uw6A-4f53A:
undetectable
1uw6B-4f53A:
undetectable		 1uw6A-4f53A:
16.77
1uw6B-4f53A:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_D_NCTD1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4f53 SUSD HOMOLOG
(Bacteroides
ovatus) 		4 / 8 TYR A 206
THR A 258
TYR A 262
LEU A 388
 None
None
None
CA  A 603 ( 4.7A)
 1.39A 1uw6D-4f53A:
undetectable
1uw6E-4f53A:
undetectable		 1uw6D-4f53A:
16.77
1uw6E-4f53A:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_G_NCTG1206_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4f53 SUSD HOMOLOG
(Bacteroides
ovatus) 		4 / 8 TYR A 206
THR A 258
TYR A 262
LEU A 388
 None
None
None
CA  A 603 ( 4.7A)
 1.40A 1uw6G-4f53A:
undetectable
1uw6H-4f53A:
undetectable		 1uw6G-4f53A:
16.77
1uw6H-4f53A:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_P_NCTP1206_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4f53 SUSD HOMOLOG
(Bacteroides
ovatus) 		4 / 8 TYR A 206
THR A 258
TYR A 262
LEU A 388
 None
None
None
CA  A 603 ( 4.7A)
 1.41A 1uw6P-4f53A:
undetectable
1uw6Q-4f53A:
undetectable		 1uw6P-4f53A:
16.77
1uw6Q-4f53A:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_T_NCTT1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4f53 SUSD HOMOLOG
(Bacteroides
ovatus) 		4 / 8 LEU A 388
TYR A 206
THR A 258
TYR A 262
 CA  A 603 ( 4.7A)
None
None
None
 1.41A 1uw6P-4f53A:
undetectable
1uw6T-4f53A:
undetectable		 1uw6P-4f53A:
16.77
1uw6T-4f53A:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_C_DVAC6_0
(GRAMICIDIN D)		 4f53 SUSD HOMOLOG
(Bacteroides
ovatus) 		3 / 3 ALA A 202
VAL A  48
TRP A  45
 None
 0.86A 1w5uC-4f53A:
undetectable
1w5uD-4f53A:
undetectable		 1w5uC-4f53A:
2.62
1w5uD-4f53A:
2.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DXR_A_SORA1002_0
(LACTOTRANSFERRIN)		 4f53 SUSD HOMOLOG
(Bacteroides
ovatus) 		3 / 3 THR A 432
PRO A 475
TYR A 290
 None
 0.82A 2dxrA-4f53A:
undetectable		 2dxrA-4f53A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_B_DVAB6_0
(GRAMICIDIN D)		 4f53 SUSD HOMOLOG
(Bacteroides
ovatus) 		3 / 3 TRP A  45
ALA A 202
VAL A  48
 None
 0.76A 2izqA-4f53A:
undetectable
2izqB-4f53A:
undetectable		 2izqA-4f53A:
2.62
2izqB-4f53A:
2.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_A_CHDA153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4f53 SUSD HOMOLOG
(Bacteroides
ovatus) 		4 / 5 ILE A 186
THR A 210
PHE A 198
PHE A 132
 None
 1.14A 3em0A-4f53A:
undetectable		 3em0A-4f53A:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_K_TFPK202_1
(PROTEIN S100-A4)		 4f53 SUSD HOMOLOG
(Bacteroides
ovatus) 		5 / 12 LEU A 138
SER A 134
ILE A 141
LEU A 183
ASP A 184
 None
 1.20A 3ko0K-4f53A:
undetectable
3ko0L-4f53A:
undetectable
3ko0S-4f53A:
undetectable
3ko0T-4f53A:
undetectable		 3ko0K-4f53A:
10.94
3ko0L-4f53A:
10.94
3ko0S-4f53A:
10.94
3ko0T-4f53A:
10.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_M_TFPM202_1
(PROTEIN S100-A4)		 4f53 SUSD HOMOLOG
(Bacteroides
ovatus) 		5 / 12 LEU A 138
SER A 134
ILE A 141
LEU A 183
ASP A 184
 None
 1.16A 3ko0M-4f53A:
undetectable
3ko0N-4f53A:
undetectable
3ko0O-4f53A:
undetectable
3ko0P-4f53A:
undetectable		 3ko0M-4f53A:
10.94
3ko0N-4f53A:
10.94
3ko0O-4f53A:
10.94
3ko0P-4f53A:
10.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_A_DVAA6_0
(GRAMICIDIN D)		 4f53 SUSD HOMOLOG
(Bacteroides
ovatus) 		3 / 3 ALA A 202
VAL A  48
TRP A  45
 None
 0.77A 3l8lA-4f53A:
undetectable
3l8lB-4f53A:
undetectable		 3l8lA-4f53A:
2.62
3l8lB-4f53A:
3.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_C_DVAC6_0
(GRAMICIDIN D)		 4f53 SUSD HOMOLOG
(Bacteroides
ovatus) 		3 / 3 ALA A 202
VAL A  48
TRP A  45
 None
 0.81A 3l8lC-4f53A:
undetectable
3l8lD-4f53A:
undetectable		 3l8lC-4f53A:
2.62
3l8lD-4f53A:
3.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEO_A_ACRA1001_2
(ALPHA-GLUCOSIDASE)		 4f53 SUSD HOMOLOG
(Bacteroides
ovatus) 		4 / 6 ILE A 386
ILE A 283
MET A 291
TRP A 455
 None
 1.32A 3weoA-4f53A:
undetectable		 3weoA-4f53A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4f53 SUSD HOMOLOG
(Bacteroides
ovatus) 		4 / 6 ILE A 450
LEU A 369
ARG A 223
MET A 226
 None
 1.18A 3wg7A-4f53A:
undetectable
3wg7J-4f53A:
undetectable		 3wg7A-4f53A:
19.76
3wg7J-4f53A:
7.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2S_A_ACTA107_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
GUIDE RNA)		 4f53 SUSD HOMOLOG
(Bacteroides
ovatus) 		3 / 3 VAL A 253
THR A 255
ARG A 364
 None
 0.57A 5b2sB-4f53A:
1.3		 5b2sB-4f53A:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2T_A_ACTA108_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
GUIDE RNA)		 4f53 SUSD HOMOLOG
(Bacteroides
ovatus) 		3 / 3 VAL A 253
THR A 255
ARG A 364
 None
 0.62A 5b2tB-4f53A:
undetectable		 5b2tB-4f53A:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C6P_A_4YHA601_1
(PROTEIN C)		 4f53 SUSD HOMOLOG
(Bacteroides
ovatus) 		4 / 6 ALA A 285
SER A 338
ASP A 414
PRO A 415
 None
 1.00A 5c6pA-4f53A:
undetectable		 5c6pA-4f53A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1802_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4f53 SUSD HOMOLOG
(Bacteroides
ovatus) 		4 / 7 THR A 150
VAL A 147
PRO A 108
ILE A 107
 None
 1.21A 5vkqA-4f53A:
undetectable
5vkqB-4f53A:
undetectable		 5vkqA-4f53A:
14.28
5vkqB-4f53A:
14.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4f53 SUSD HOMOLOG
(Bacteroides
ovatus) 		4 / 7 THR A 150
VAL A 147
PRO A 108
ILE A 107
 None
 1.23A 5vkqC-4f53A:
undetectable
5vkqD-4f53A:
undetectable		 5vkqC-4f53A:
14.28
5vkqD-4f53A:
14.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9Y_A_ACTA412_0
(UNCHARACTERIZED
PROTEIN KDOO)		 4f53 SUSD HOMOLOG
(Bacteroides
ovatus) 		3 / 3 ARG A 471
PHE A 443
ARG A 370
 None
 1.15A 5y9yA-4f53A:
undetectable		 5y9yA-4f53A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWT_D_BEZD202_0
(PR 10 PROTEIN)		 4f53 SUSD HOMOLOG
(Bacteroides
ovatus) 		3 / 3 PHE A 109
ASP A 111
LYS A 106
 None
 0.81A 6awtD-4f53A:
undetectable		 6awtD-4f53A:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_2
(-)		 4f53 SUSD HOMOLOG
(Bacteroides
ovatus) 		4 / 8 VAL A 436
TYR A 402
ASN A 292
GLU A 410
 None
 1.28A 6gneB-4f53A:
undetectable		 6gneB-4f53A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H3D_A_DHIA601_0
(DUF2338
DOMAIN-CONTAINING
PROTEIN)		 4f53 SUSD HOMOLOG
(Bacteroides
ovatus) 		4 / 5 TYR A  95
ASN A  99
TYR A  98
PHE A  78
 None
 1.48A 6h3dA-4f53A:
0.6		 6h3dA-4f53A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_I_PCFI101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 4f53 SUSD HOMOLOG
(Bacteroides
ovatus) 		5 / 11 SER A 284
VAL A 409
GLY A 407
SER A 405
ALA A 404
 None
 1.32A 6hu9A-4f53A:
undetectable
6hu9E-4f53A:
undetectable
6hu9I-4f53A:
undetectable		 6hu9A-4f53A:
22.61
6hu9E-4f53A:
16.44
6hu9I-4f53A:
8.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_T_PCFT101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 4f53 SUSD HOMOLOG
(Bacteroides
ovatus) 		5 / 10 SER A 284
VAL A 409
GLY A 407
SER A 405
ALA A 404
 None
 1.30A 6hu9L-4f53A:
undetectable
6hu9P-4f53A:
undetectable
6hu9T-4f53A:
undetectable		 6hu9L-4f53A:
22.61
6hu9P-4f53A:
16.44
6hu9T-4f53A:
8.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4f53 SUSD HOMOLOG
(Bacteroides
ovatus) 		4 / 6 ILE A 451
LEU A 447
ARG A 223
MET A 226
 None
 1.04A 6nmfN-4f53A:
0.4
6nmfW-4f53A:
undetectable		 6nmfN-4f53A:
19.76
6nmfW-4f53A:
7.38