SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4f55'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_F_SAMF301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4f55 SPORE CORTEX-LYTIC
ENZYME
(Bacillus
cereus) 		5 / 12 GLY A 141
GLY A 222
ASN A 221
ALA A 219
ALA A 170
 None
 1.08A 2bm9F-4f55A:
undetectable		 2bm9F-4f55A:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_B_VIAB902_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4f55 SPORE CORTEX-LYTIC
ENZYME
(Bacillus
cereus) 		5 / 12 ASN A 209
ALA A 219
ILE A 220
ALA A 153
ILE A 190
 None
 1.06A 2h42B-4f55A:
undetectable		 2h42B-4f55A:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_B_VIAB902_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4f55 SPORE CORTEX-LYTIC
ENZYME
(Bacillus
cereus) 		5 / 12 ASN A 209
ALA A 219
VAL A 154
ALA A 153
ILE A 190
 None
 1.13A 2h42B-4f55A:
undetectable		 2h42B-4f55A:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_C_VIAC903_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4f55 SPORE CORTEX-LYTIC
ENZYME
(Bacillus
cereus) 		5 / 12 LEU A 217
ALA A 219
VAL A 154
ALA A 153
ILE A 190
 None
 0.95A 2h42C-4f55A:
undetectable		 2h42C-4f55A:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNJ_A_225A501_1
(CYTOCHROME P450 2C8)		 4f55 SPORE CORTEX-LYTIC
ENZYME
(Bacillus
cereus) 		5 / 10 VAL A 169
ALA A 170
VAL A 186
ILE A 190
VAL A 189
 None
 0.86A 2nnjA-4f55A:
undetectable		 2nnjA-4f55A:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4f55 SPORE CORTEX-LYTIC
ENZYME
(Bacillus
cereus) 		5 / 12 TYR A 232
VAL A 169
LEU A 174
ILE A 190
VAL A 186
 PO4  A 302 (-4.5A)
None
None
None
None
 1.19A 3w68A-4f55A:
undetectable		 3w68A-4f55A:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CU6_A_ACTA403_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 4f55 SPORE CORTEX-LYTIC
ENZYME
(Bacillus
cereus) 		5 / 6 TYR A 232
ILE A 249
VAL A 172
PRO A 225
ALA A 229
 PO4  A 302 (-4.5A)
None
None
None
None
 0.99A 5cu6A-4f55A:
undetectable		 5cu6A-4f55A:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OTR_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 4f55 SPORE CORTEX-LYTIC
ENZYME
(Bacillus
cereus) 		4 / 5 TYR A 232
VAL A 172
PRO A 225
ALA A 229
 PO4  A 302 (-4.5A)
None
None
None
 0.84A 5otrA-4f55A:
undetectable		 5otrA-4f55A:
16.96