SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4f58'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXT_A_MTXA2000_1
(ANTI-METHOTREXATE
CDR1-3 GRAFT VHH)		 4f58 HEAVY CHAIN OF FAB
OF A NEUTRALIZING
ANTIBODY L3
(Homo
sapiens) 		5 / 12 ALA H  24
MET H  34
ARG H  71
ASN H  76
VAL H  78
 None
 1.04A 3qxtA-4f58H:
20.3		 3qxtA-4f58H:
61.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXT_A_MTXA2000_1
(ANTI-METHOTREXATE
CDR1-3 GRAFT VHH)		 4f58 HEAVY CHAIN OF FAB
OF A NEUTRALIZING
ANTIBODY L3
(Homo
sapiens) 		5 / 12 VAL H   2
ALA H  24
MET H  34
ARG H  71
VAL H  78
 None
 1.00A 3qxtA-4f58H:
20.3		 3qxtA-4f58H:
61.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXT_B_MTXB2000_1
(ANTI-METHOTREXATE
CDR1-3 GRAFT VHH)		 4f58 HEAVY CHAIN OF FAB
OF A NEUTRALIZING
ANTIBODY L3
(Homo
sapiens) 		6 / 12 VAL H   2
LEU H   4
ALA H  24
MET H  34
ARG H  71
VAL H  78
 None
 0.85A 3qxtB-4f58H:
20.5		 3qxtB-4f58H:
61.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TZF_B_08DB280_1
(7,8-DIHYDROPTEROATE
SYNTHASE)		 4f58 HEAVY CHAIN OF FAB
OF A NEUTRALIZING
ANTIBODY L3
(Homo
sapiens) 		4 / 8 THR H  87
PRO H  84
GLY H 174
SER H 113
 None
 1.05A 3tzfB-4f58H:
undetectable		 3tzfB-4f58H:
22.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6CJK_B_ACTB302_0
(IMMUNOGLOBULIN FAB
HEAVY CHAIN)		 4f58 HEAVY CHAIN OF FAB
OF A NEUTRALIZING
ANTIBODY L3
(Homo
sapiens) 		3 / 3 TYR H  59
GLY H  65
THR H  68
 SO4  H 301 (-4.2A)
None
SO4  H 301 ( 4.3A)
 0.14A 6cjkB-4f58H:
19.9		 6cjkB-4f58H:
61.23