SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4f5x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSE_A_EAAA224_1
(GLUTATHIONE
TRANSFERASE)		 4f5x RNA-DIRECTED RNA
POLYMERASE
(Rotavirus
A) 		5 / 12 TYR W 561
LEU W 568
VAL W 589
ALA W 599
PHE W 534
 None
 1.22A 1gseA-4f5xW:
undetectable		 1gseA-4f5xW:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_SAMA293_1
(GLYCINE
N-METHYLTRANSFERASE)		 4f5x RNA-DIRECTED RNA
POLYMERASE
(Rotavirus
A) 		3 / 3 ARG W 723
ASP W 632
ASN W 604
 None
 0.94A 1nbhA-4f5xW:
undetectable		 1nbhA-4f5xW:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_1
(GLYCINE
N-METHYLTRANSFERASE)		 4f5x RNA-DIRECTED RNA
POLYMERASE
(Rotavirus
A) 		3 / 3 ARG W 723
ASP W 632
ASN W 604
 None
 0.94A 1nbhD-4f5xW:
undetectable		 1nbhD-4f5xW:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_A_BEZA501_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4f5x RNA-DIRECTED RNA
POLYMERASE
(Rotavirus
A) 		4 / 7 ARG W 814
ILE W 471
PRO W 435
GLU W 390
 None
 1.06A 1oniA-4f5xW:
undetectable
1oniB-4f5xW:
undetectable		 1oniA-4f5xW:
8.95
1oniB-4f5xW:
8.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_B_BEZB503_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4f5x RNA-DIRECTED RNA
POLYMERASE
(Rotavirus
A) 		4 / 6 ARG W 814
ILE W 471
PRO W 435
GLU W 390
 None
 1.02A 1oniB-4f5xW:
undetectable
1oniC-4f5xW:
undetectable		 1oniB-4f5xW:
8.95
1oniC-4f5xW:
8.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_E_BEZE509_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4f5x RNA-DIRECTED RNA
POLYMERASE
(Rotavirus
A) 		4 / 7 ILE W 471
PRO W 435
GLU W 390
ARG W 814
 None
 1.10A 1oniD-4f5xW:
undetectable
1oniE-4f5xW:
undetectable		 1oniD-4f5xW:
8.95
1oniE-4f5xW:
8.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_G_BEZG513_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4f5x RNA-DIRECTED RNA
POLYMERASE
(Rotavirus
A) 		4 / 5 ARG W 814
ILE W 471
PRO W 435
GLU W 390
 None
 1.06A 1oniG-4f5xW:
undetectable
1oniH-4f5xW:
undetectable		 1oniG-4f5xW:
8.95
1oniH-4f5xW:
8.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_I_BEZI517_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4f5x RNA-DIRECTED RNA
POLYMERASE
(Rotavirus
A) 		4 / 7 ILE W 471
PRO W 435
GLU W 390
ARG W 814
 None
 0.99A 1oniG-4f5xW:
undetectable
1oniI-4f5xW:
undetectable		 1oniG-4f5xW:
8.95
1oniI-4f5xW:
8.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA8_A_FOLA161_1
(DIHYDROFOLATE
REDUCTASE)		 4f5x RNA-DIRECTED RNA
POLYMERASE
(Rotavirus
A) 		3 / 3 ASP W 923
LYS W 927
ARG W 932
 None
 1.14A 1ra8A-4f5xW:
undetectable		 1ra8A-4f5xW:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_B_DVAB6_0
(GRAMICIDIN A)		 4f5x RNA-DIRECTED RNA
POLYMERASE
(Rotavirus
A) 		3 / 3 ALA W 668
VAL W 521
TRP W 524
 None
 0.87A 1tkqB-4f5xW:
undetectable		 1tkqB-4f5xW:
1.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_C_SPMC1434_1
(NITROALKANE OXIDASE)		 4f5x RNA-DIRECTED RNA
POLYMERASE
(Rotavirus
A) 		5 / 12 LEU W 288
MET W 322
LEU W 311
VAL W 312
ASP W 313
 None
 1.20A 2c12C-4f5xW:
undetectable		 2c12C-4f5xW:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HC4_A_VDXA525_1
(VITAMIN D RECEPTOR)		 4f5x RNA-DIRECTED RNA
POLYMERASE
(Rotavirus
A) 		5 / 12 PHE W 766
LEU W 757
VAL W 756
LEU W  75
LEU W 858
 None
 1.16A 2hc4A-4f5xW:
undetectable		 2hc4A-4f5xW:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HC4_A_VDXA525_1
(VITAMIN D RECEPTOR)		 4f5x RNA-DIRECTED RNA
POLYMERASE
(Rotavirus
A) 		5 / 12 PHE W 766
LEU W 757
VAL W 756
LEU W 858
LEU W 791
 None
 1.31A 2hc4A-4f5xW:
undetectable		 2hc4A-4f5xW:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PH9_A_GNTA301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4f5x RNA-DIRECTED RNA
POLYMERASE
(Rotavirus
A) 		4 / 7 TYR W 775
TYR W1004
TYR W1036
ILE W1032
 None
 1.25A 2ph9A-4f5xW:
undetectable
2ph9B-4f5xW:
undetectable		 2ph9A-4f5xW:
13.38
2ph9B-4f5xW:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_B_SAMB298_0
(PUTATIVE
MODIFICATION
METHYLASE)		 4f5x RNA-DIRECTED RNA
POLYMERASE
(Rotavirus
A) 		5 / 12 ALA W 603
SER W 522
ALA W 678
GLY W 630
LEU W 605
 None
 1.13A 2zifB-4f5xW:
undetectable		 2zifB-4f5xW:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_1
(N,N-DIMETHYLTRANSFER
ASE)		 4f5x RNA-DIRECTED RNA
POLYMERASE
(Rotavirus
A) 		3 / 3 TYR W1001
GLU W 922
ASP W 984
 None
 0.81A 3bxoA-4f5xW:
undetectable		 3bxoA-4f5xW:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_B_SAMB238_1
(N,N-DIMETHYLTRANSFER
ASE)		 4f5x RNA-DIRECTED RNA
POLYMERASE
(Rotavirus
A) 		3 / 3 TYR W1001
GLU W 922
ASP W 984
 None
 0.83A 3bxoB-4f5xW:
undetectable		 3bxoB-4f5xW:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR4_X_PNTX101_0
(PROTEIN S100-B)		 4f5x RNA-DIRECTED RNA
POLYMERASE
(Rotavirus
A) 		3 / 3 CYH W  38
HIS W  42
PHE W  41
 None
 0.89A 3cr4X-4f5xW:
undetectable		 3cr4X-4f5xW:
7.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK2_X_LDPX433_1
(6-HYDROXY-L-NICOTINE
OXIDASE)		 4f5x RNA-DIRECTED RNA
POLYMERASE
(Rotavirus
A) 		4 / 7 ASN W 421
MET W 422
LEU W 408
LEU W 839
 None
 1.28A 3nk2X-4f5xW:
undetectable		 3nk2X-4f5xW:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OCT_A_1N1A663_2
(TYROSINE-PROTEIN
KINASE BTK)		 4f5x RNA-DIRECTED RNA
POLYMERASE
(Rotavirus
A) 		4 / 5 PHE W 731
ILE W   7
ASN W 716
PHE W 147
 None
 1.29A 3octA-4f5xW:
undetectable		 3octA-4f5xW:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAV_A_RAVA183_1
(FERRITIN LIGHT CHAIN)		 4f5x RNA-DIRECTED RNA
POLYMERASE
(Rotavirus
A) 		4 / 6 LEU W 232
SER W 235
ALA W 100
LEU W 240
 None
 0.96A 3ravA-4f5xW:
undetectable		 3ravA-4f5xW:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		 4f5x RNA-DIRECTED RNA
POLYMERASE
(Rotavirus
A) 		4 / 6 LEU W 232
SER W 235
ALA W 100
LEU W 240
 None
 0.97A 3rd0A-4f5xW:
undetectable		 3rd0A-4f5xW:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_A_RBVA601_1
(RNA POLYMERASE)		 4f5x RNA-DIRECTED RNA
POLYMERASE
(Rotavirus
A) 		5 / 9 SER W 591
THR W 596
ASN W 600
GLY W 630
ASP W 629
 None
 1.45A 3sfuA-4f5xW:
2.3		 3sfuA-4f5xW:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_A_TPVA100_1
(HIV-1 PROTEASE)		 4f5x RNA-DIRECTED RNA
POLYMERASE
(Rotavirus
A) 		5 / 11 ILE W 682
GLY W 684
ILE W 316
PRO W 901
THR W 902
 None
 1.00A 3spkA-4f5xW:
undetectable		 3spkA-4f5xW:
6.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4f5x RNA-DIRECTED RNA
POLYMERASE
(Rotavirus
A) 		6 / 12 GLY W 592
ARG W 458
ILE W 575
ALA W 590
ARG W 460
ALA W 343
 None
 1.25A 3sudC-4f5xW:
undetectable		 3sudC-4f5xW:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_B_SAMB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4f5x RNA-DIRECTED RNA
POLYMERASE
(Rotavirus
A) 		5 / 12 LEU W 465
GLY W 450
ILE W 447
ARG W 460
ALA W 590
 None
 0.67A 3uj7B-4f5xW:
undetectable		 3uj7B-4f5xW:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_C_VIVC301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4f5x RNA-DIRECTED RNA
POLYMERASE
(Rotavirus
A) 		5 / 12 ILE W 677
VAL W 651
ILE W 608
VAL W 611
LEU W 612
 None
 1.22A 3w68C-4f5xW:
undetectable		 3w68C-4f5xW:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 4f5x RNA-DIRECTED RNA
POLYMERASE
(Rotavirus
A) 		5 / 12 SER W 140
THR W 727
ILE W 211
ASN W 208
PHE W 731
 None
 1.38A 4c49B-4f5xW:
undetectable		 4c49B-4f5xW:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4f5x RNA-DIRECTED RNA
POLYMERASE
(Rotavirus
A) 		4 / 7 GLU W 676
ILE W 675
ASN W 633
ASP W 632
 None
 1.03A 4d39B-4f5xW:
undetectable		 4d39B-4f5xW:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIX_A_NIMA201_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 4f5x RNA-DIRECTED RNA
POLYMERASE
(Rotavirus
A) 		4 / 4 LEU W1017
ALA W1045
ILE W1042
LYS W1016
 None
 1.42A 4eixA-4f5xW:
undetectable		 4eixA-4f5xW:
7.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8C_A_ADNA401_2
(SUGAR KINASE)		 4f5x RNA-DIRECTED RNA
POLYMERASE
(Rotavirus
A) 		3 / 3 SER W 671
TYR W 518
PRO W 281
 None
 0.85A 4k8cA-4f5xW:
undetectable		 4k8cA-4f5xW:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 4f5x RNA-DIRECTED RNA
POLYMERASE
(Rotavirus
A) 		3 / 3 SER W 671
TYR W 518
PRO W 281
 None
 0.83A 4kahA-4f5xW:
undetectable		 4kahA-4f5xW:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_B_ADNB502_2
(PROBABLE SUGAR
KINASE PROTEIN)		 4f5x RNA-DIRECTED RNA
POLYMERASE
(Rotavirus
A) 		3 / 3 SER W 671
TYR W 518
PRO W 281
 None
 0.82A 4kahB-4f5xW:
undetectable		 4kahB-4f5xW:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 4f5x RNA-DIRECTED RNA
POLYMERASE
(Rotavirus
A) 		3 / 3 SER W 671
TYR W 518
PRO W 281
 None
 0.85A 4kanA-4f5xW:
undetectable		 4kanA-4f5xW:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 4f5x RNA-DIRECTED RNA
POLYMERASE
(Rotavirus
A) 		3 / 3 SER W 671
TYR W 518
PRO W 281
 None
 0.84A 4kanB-4f5xW:
undetectable		 4kanB-4f5xW:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 4f5x RNA-DIRECTED RNA
POLYMERASE
(Rotavirus
A) 		3 / 3 SER W 671
TYR W 518
PRO W 281
 None
 0.80A 4kbeA-4f5xW:
undetectable		 4kbeA-4f5xW:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 4f5x RNA-DIRECTED RNA
POLYMERASE
(Rotavirus
A) 		3 / 3 SER W 671
TYR W 518
PRO W 281
 None
 0.80A 4kbeB-4f5xW:
undetectable		 4kbeB-4f5xW:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KMM_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4f5x RNA-DIRECTED RNA
POLYMERASE
(Rotavirus
A) 		4 / 5 LEU W 791
ARG W 850
PRO W 752
SER W  73
 None
 1.46A 4kmmB-4f5xW:
undetectable		 4kmmB-4f5xW:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 4f5x RNA-DIRECTED RNA
POLYMERASE
(Rotavirus
A) 		3 / 3 SER W 671
TYR W 518
PRO W 281
 None
 0.86A 4lbgA-4f5xW:
undetectable		 4lbgA-4f5xW:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 4f5x RNA-DIRECTED RNA
POLYMERASE
(Rotavirus
A) 		3 / 3 SER W 671
TYR W 518
PRO W 281
 None
 0.85A 4lbgB-4f5xW:
undetectable		 4lbgB-4f5xW:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_A_SPMA202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4f5x RNA-DIRECTED RNA
POLYMERASE
(Rotavirus
A) 		4 / 8 GLU W 593
ILE W 538
GLN W 565
ILE W 566
 None
 0.82A 4mj8A-4f5xW:
undetectable		 4mj8A-4f5xW:
10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OK1_A_198A1001_1
(ANDROGEN RECEPTOR)		 4f5x RNA-DIRECTED RNA
POLYMERASE
(Rotavirus
A) 		5 / 12 LEU W 542
LEU W 558
VAL W 477
THR W 564
ILE W 438
 None
 1.11A 4ok1A-4f5xW:
undetectable		 4ok1A-4f5xW:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PB1_A_RBVA501_1
(NUPC FAMILY PROTEIN)		 4f5x RNA-DIRECTED RNA
POLYMERASE
(Rotavirus
A) 		5 / 12 GLY W 702
TYR W1080
LEU W 135
ASN W 840
SER W 846
 None
 1.35A 4pb1A-4f5xW:
1.1		 4pb1A-4f5xW:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCU_A_SAMA603_0
(CYSTATHIONINE
BETA-SYNTHASE)		 4f5x RNA-DIRECTED RNA
POLYMERASE
(Rotavirus
A) 		4 / 7 ASP W 341
PRO W 576
THR W 459
ASP W 453
 None
 1.07A 4pcuA-4f5xW:
undetectable		 4pcuA-4f5xW:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_A_RBFA201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 4f5x RNA-DIRECTED RNA
POLYMERASE
(Rotavirus
A) 		4 / 8 ILE W 773
VAL W 993
LEU W 996
ILE W1073
 None
 0.78A 4r38A-4f5xW:
undetectable		 4r38A-4f5xW:
9.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA502_1
(PENTALENIC ACID
SYNTHASE)		 4f5x RNA-DIRECTED RNA
POLYMERASE
(Rotavirus
A) 		5 / 9 VAL W 765
LEU W 713
THR W 136
LEU W 135
ILE W 134
 None
 1.31A 4ubsA-4f5xW:
undetectable		 4ubsA-4f5xW:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 4f5x RNA-DIRECTED RNA
POLYMERASE
(Rotavirus
A) 		4 / 7 ASN W 906
LYS W1047
TYR W1044
LEU W 892
 None
 1.22A 4yv5A-4f5xW:
undetectable		 4yv5A-4f5xW:
7.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 4f5x RNA-DIRECTED RNA
POLYMERASE
(Rotavirus
A) 		4 / 6 LEU W 203
TYR W 202
PRO W 200
TYR W 234
 None
 1.30A 4z4gA-4f5xW:
undetectable		 4z4gA-4f5xW:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2Q_A_ACTA1728_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9)		 4f5x RNA-DIRECTED RNA
POLYMERASE
(Rotavirus
A) 		3 / 3 ASN W 697
SER W 209
ARG W 237
 None
 0.93A 5b2qA-4f5xW:
undetectable		 5b2qA-4f5xW:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HHJ_B_GLYB404_0
(RETRON-TYPE REVERSE
TRANSCRIPTASE)		 4f5x RNA-DIRECTED RNA
POLYMERASE
(Rotavirus
A) 		4 / 4 GLN W 346
ALA W 588
GLN W 528
THR W 531
 None
 1.32A 5hhjB-4f5xW:
10.1		 5hhjB-4f5xW:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M35_A_BEZA302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 4f5x RNA-DIRECTED RNA
POLYMERASE
(Rotavirus
A) 		4 / 5 PHE W 751
THR W 734
MET W 737
GLN W 738
 None
 0.75A 5m35A-4f5xW:
undetectable		 5m35A-4f5xW:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NR3_A_95EA401_0
(DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3B)		 4f5x RNA-DIRECTED RNA
POLYMERASE
(Rotavirus
A) 		4 / 7 ILE W 367
TRP W 524
ASP W 525
SER W 527
 None
 1.40A 5nr3A-4f5xW:
undetectable		 5nr3A-4f5xW:
9.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB303_1
(BIFUNCTIONAL PROTEIN
FOLD)		 4f5x RNA-DIRECTED RNA
POLYMERASE
(Rotavirus
A) 		4 / 5 TYR W 469
GLN W 473
GLY W 450
ILE W 447
 None
 1.30A 6debB-4f5xW:
undetectable		 6debB-4f5xW:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNA_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 4f5x RNA-DIRECTED RNA
POLYMERASE
(Rotavirus
A) 		3 / 3 ARG W 879
LYS W 882
TYR W1036
 None
 1.32A 6gnaA-4f5xW:
undetectable		 6gnaA-4f5xW:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNB_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 4f5x RNA-DIRECTED RNA
POLYMERASE
(Rotavirus
A) 		3 / 3 ARG W 879
LYS W 882
TYR W1036
 None
 1.32A 6gnbA-4f5xW:
undetectable		 6gnbA-4f5xW:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_A_TKTA508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 4f5x RNA-DIRECTED RNA
POLYMERASE
(Rotavirus
A) 		4 / 8 ASP W 131
ILE W 134
ARG W 701
ASN W 716
 None
 1.19A 6hisA-4f5xW:
2.3
6hisB-4f5xW:
2.3		 6hisA-4f5xW:
6.01
6hisB-4f5xW:
6.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_B_TKTB508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 4f5x RNA-DIRECTED RNA
POLYMERASE
(Rotavirus
A) 		4 / 8 ASP W 131
ILE W 134
ARG W 701
ASN W 716
 None
 1.19A 6hisB-4f5xW:
2.3
6hisC-4f5xW:
2.2		 6hisB-4f5xW:
6.01
6hisC-4f5xW:
6.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_C_TKTC508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 4f5x RNA-DIRECTED RNA
POLYMERASE
(Rotavirus
A) 		4 / 8 ASP W 131
ILE W 134
ARG W 701
ASN W 716
 None
 1.19A 6hisC-4f5xW:
2.2
6hisD-4f5xW:
2.2		 6hisC-4f5xW:
6.01
6hisD-4f5xW:
6.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_D_TKTD501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 4f5x RNA-DIRECTED RNA
POLYMERASE
(Rotavirus
A) 		4 / 8 ASP W 131
ILE W 134
ARG W 701
ASN W 716
 None
 1.19A 6hisD-4f5xW:
2.2
6hisE-4f5xW:
2.2		 6hisD-4f5xW:
6.01
6hisE-4f5xW:
6.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_E_TKTE501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 4f5x RNA-DIRECTED RNA
POLYMERASE
(Rotavirus
A) 		4 / 8 ASN W 716
ASP W 131
ILE W 134
ARG W 701
 None
 1.21A 6hisA-4f5xW:
2.3
6hisE-4f5xW:
2.2		 6hisA-4f5xW:
6.01
6hisE-4f5xW:
6.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_A_AM2A301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4f5x RNA-DIRECTED RNA
POLYMERASE
(Rotavirus
A) 		4 / 8 ASP W 728
ARG W 729
ASP W 770
GLU W 769
 None
 1.06A 6mn4A-4f5xW:
undetectable		 6mn4A-4f5xW:
13.37