SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4f67'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4001_1
(SERUM ALBUMIN)		 4f67 UPF0176 PROTEIN
LPG2838
(Legionella
pneumophila) 		4 / 5 ARG A 229
ALA A  50
ASP A 227
GLY A  48
 None
 1.15A 1e7cA-4f67A:
undetectable		 1e7cA-4f67A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZSE_A_PAUA600_0
(PANTOTHENATE KINASE)		 4f67 UPF0176 PROTEIN
LPG2838
(Legionella
pneumophila) 		4 / 7 ARG A  64
PHE A  59
PHE A  49
ILE A  25
 None
 1.25A 2zseA-4f67A:
undetectable		 2zseA-4f67A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEO_A_SAMA328_0
(MODIFICATION
METHYLASE HHAI)		 4f67 UPF0176 PROTEIN
LPG2838
(Legionella
pneumophila) 		5 / 12 LEU A 140
GLY A 221
ASP A 135
ILE A 147
LEU A 130
 None
 0.99A 3eeoA-4f67A:
undetectable		 3eeoA-4f67A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_A_SPMA201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4f67 UPF0176 PROTEIN
LPG2838
(Legionella
pneumophila) 		4 / 6 ASN A 134
GLU A 139
TYR A 138
GLU A 137
 None
 1.40A 4mi4A-4f67A:
undetectable		 4mi4A-4f67A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_A_0HKA2001_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 4f67 UPF0176 PROTEIN
LPG2838
(Legionella
pneumophila) 		5 / 12 ASP A 203
THR A 186
THR A 187
ALA A 188
TYR A  10
 None
 1.19A 4u15A-4f67A:
undetectable		 4u15A-4f67A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HQA_A_ACRA705_2
(ALPHA-GLUCOSIDASE)		 4f67 UPF0176 PROTEIN
LPG2838
(Legionella
pneumophila) 		4 / 8 PHE A 121
GLU A 117
HIS A 202
THR A 142
 None
 1.24A 5hqaA-4f67A:
undetectable		 5hqaA-4f67A:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4f67 UPF0176 PROTEIN
LPG2838
(Legionella
pneumophila) 		4 / 6 PHE A   9
VAL A  45
MET A  29
ILE A  25
 None
 1.30A 5iwuA-4f67A:
undetectable		 5iwuA-4f67A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_A_ACTA803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 4f67 UPF0176 PROTEIN
LPG2838
(Legionella
pneumophila) 		4 / 4 GLU A  23
PRO A  24
ILE A  25
LEU A  26
 None
 0.93A 5m45A-4f67A:
undetectable		 5m45A-4f67A:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_D_ACTD803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 4f67 UPF0176 PROTEIN
LPG2838
(Legionella
pneumophila) 		4 / 4 GLU A  23
PRO A  24
ILE A  25
LEU A  26
 None
 0.98A 5m45D-4f67A:
undetectable		 5m45D-4f67A:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_G_ACTG803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 4f67 UPF0176 PROTEIN
LPG2838
(Legionella
pneumophila) 		4 / 4 GLU A  23
PRO A  24
ILE A  25
LEU A  26
 None
 0.95A 5m45G-4f67A:
undetectable		 5m45G-4f67A:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_J_ACTJ803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 4f67 UPF0176 PROTEIN
LPG2838
(Legionella
pneumophila) 		4 / 4 GLU A  23
PRO A  24
ILE A  25
LEU A  26
 None
 1.00A 5m45J-4f67A:
undetectable		 5m45J-4f67A:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND7_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 4f67 UPF0176 PROTEIN
LPG2838
(Legionella
pneumophila) 		5 / 12 ASP A 135
GLU A 137
LEU A 165
ARG A 163
ARG A 182
 None
 1.10A 5nd7B-4f67A:
undetectable		 5nd7B-4f67A:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_B_ACTB804_0
(UNCHARACTERIZED
PROTEIN)		 4f67 UPF0176 PROTEIN
LPG2838
(Legionella
pneumophila) 		4 / 4 HIS A  30
VAL A  89
LEU A  26
ALA A  87
 None
 1.22A 6d8pB-4f67A:
3.3		 6d8pB-4f67A:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECX_A_SAMA1301_0
(STIE PROTEIN)		 4f67 UPF0176 PROTEIN
LPG2838
(Legionella
pneumophila) 		5 / 12 LEU A  21
ASP A  71
VAL A  45
LEU A  40
ILE A  39
 None
 1.00A 6ecxA-4f67A:
undetectable		 6ecxA-4f67A:
22.75