SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4f6a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1J3J_A_CP6A609_1 (BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE)	4f6a	BH1408 PROTEIN (Bacillus halodurans)	5 / 10	ALA A 6 ASP A 10 ILE A 105 ILE A 3 THR A 7	None None UNL A 501 ( 4.7A) None None	1.30A	1j3jA-4f6aA: undetectable	1j3jA-4f6aA: 21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1J3J_B_CP6B709_1 (BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE)	4f6a	BH1408 PROTEIN (Bacillus halodurans)	5 / 9	ALA A 6 ASP A 10 ILE A 105 ILE A 3 THR A 7	None None UNL A 501 ( 4.7A) None None	1.34A	1j3jB-4f6aA: undetectable	1j3jB-4f6aA: 21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2X45_C_HSMC1161_1 (ALLERGEN ARG R 1)	4f6a	BH1408 PROTEIN (Bacillus halodurans)	4 / 5	VAL A 89 TYR A 90 ASP A 93 SER A 70	None	1.16A	2x45C-4f6aA: undetectable	2x45C-4f6aA: 19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BJW_A_SVRA508_1 (PHOSPHOLIPASE A2)	4f6a	BH1408 PROTEIN (Bacillus halodurans)	4 / 5	VAL A 58 PHE A 110 ARG A 4 ARG A 16	None	1.05A	3bjwE-4f6aA: undetectable	3bjwE-4f6aA: 21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3P73_A_ACTA275_0 (MHC RFP-Y CLASS I ALPHA CHAIN)	4f6a	BH1408 PROTEIN (Bacillus halodurans)	3 / 3	ILE A 66 VAL A 58 ARG A 4	None	0.65A	3p73A-4f6aA: undetectable	3p73A-4f6aA: 20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3QOW_A_SAMA417_1 (HISTONE-LYSINE N-METHYLTRANSFERASE)	4f6a	BH1408 PROTEIN (Bacillus halodurans)	3 / 3	THR A 151 ASP A 128 GLU A 126	None	0.79A	3qowA-4f6aA: undetectable	3qowA-4f6aA: 15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3WZD_A_LEVA1201_2 (VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2)	4f6a	BH1408 PROTEIN (Bacillus halodurans)	4 / 5	ILE A 109 VAL A 14 LEU A 40 ASP A 93	None	1.07A	3wzdA-4f6aA: undetectable	3wzdA-4f6aA: 19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4OKX_A_198A1002_1 (ANDROGEN RECEPTOR)	4f6a	BH1408 PROTEIN (Bacillus halodurans)	5 / 12	LEU A 108 GLY A 106 LEU A 94 VAL A 58 VAL A 21	None UNL A 501 ( 3.5A) None None None	1.22A	4okxA-4f6aA: undetectable	4okxA-4f6aA: 22.05

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1J3J_A_CP6A609_1","BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE","4f6a","BH1408 PROTEIN","Bacillus halodurans",5,"ALA A   6;ASP A  10;ILE A 105;ILE A   3;THR A   7","None;None;UNL A 501 ( 4.7A);None;None","1.30A","1j3jA-4f6aA:undetectable","1j3jA-4f6aA:21.72"],["1J3J_B_CP6B709_1","BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE","4f6a","BH1408 PROTEIN","Bacillus halodurans",5,"ALA A   6;ASP A  10;ILE A 105;ILE A   3;THR A   7","None;None;UNL A 501 ( 4.7A);None;None","1.34A","1j3jB-4f6aA:undetectable","1j3jB-4f6aA:21.72"],["2X45_C_HSMC1161_1","ALLERGEN ARG R 1","4f6a","BH1408 PROTEIN","Bacillus halodurans",4,"VAL A  89;TYR A  90;ASP A  93;SER A  70","None","1.16A","2x45C-4f6aA:undetectable","2x45C-4f6aA:19.08"],["3BJW_A_SVRA508_1","PHOSPHOLIPASE A2;PHOSPHOLIPASE A2","4f6a","BH1408 PROTEIN","Bacillus halodurans",4,"VAL A  58;PHE A 110;ARG A   4;ARG A  16","None","1.05A","3bjwE-4f6aA:undetectable","3bjwE-4f6aA:21.52"],["3P73_A_ACTA275_0","MHC RFP-Y CLASS I ALPHA CHAIN","4f6a","BH1408 PROTEIN","Bacillus halodurans",3,"ILE A  66;VAL A  58;ARG A   4","None","0.65A","3p73A-4f6aA:undetectable","3p73A-4f6aA:20.15"],["3QOW_A_SAMA417_1","HISTONE-LYSINE N-METHYLTRANSFERASE","4f6a","BH1408 PROTEIN","Bacillus halodurans",3,"THR A 151;ASP A 128;GLU A 126","None","0.79A","3qowA-4f6aA:undetectable","3qowA-4f6aA:15.96"],["3WZD_A_LEVA1201_2","VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2","4f6a","BH1408 PROTEIN","Bacillus halodurans",4,"ILE A 109;VAL A  14;LEU A  40;ASP A  93","None","1.07A","3wzdA-4f6aA:undetectable","3wzdA-4f6aA:19.87"],["4OKX_A_198A1002_1","ANDROGEN RECEPTOR","4f6a","BH1408 PROTEIN","Bacillus halodurans",5,"LEU A 108;GLY A 106;LEU A  94;VAL A  58;VAL A  21","None;UNL A 501 ( 3.5A);None;None;None","1.22A","4okxA-4f6aA:undetectable","4okxA-4f6aA:22.05"]]