SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4f6c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_1
(DNA GYRASE SUBUNIT B)		 4f6c AUSA REDUCTASE
DOMAIN PROTEIN
(Staphylococcus
aureus) 		5 / 12 ARG A2070
ILE A2071
ILE A2061
ALA A2052
THR A2047
 None
 1.14A 1kijB-4f6cA:
undetectable		 1kijB-4f6cA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_C_NCAC439_0
(ADP-RIBOSYL CYCLASE)		 4f6c AUSA REDUCTASE
DOMAIN PROTEIN
(Staphylococcus
aureus) 		3 / 3 TRP A2377
PHE A2274
TRP A2381
 None
 1.50A 1r15C-4f6cA:
2.5		 1r15C-4f6cA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_F_NCAF469_0
(ADP-RIBOSYL CYCLASE)		 4f6c AUSA REDUCTASE
DOMAIN PROTEIN
(Staphylococcus
aureus) 		3 / 3 TRP A2377
PHE A2274
TRP A2381
 None
 1.49A 1r15F-4f6cA:
2.5		 1r15F-4f6cA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_G_NCAG479_0
(ADP-RIBOSYL CYCLASE)		 4f6c AUSA REDUCTASE
DOMAIN PROTEIN
(Staphylococcus
aureus) 		3 / 3 TRP A2377
PHE A2274
TRP A2381
 None
 1.49A 1r15G-4f6cA:
2.4		 1r15G-4f6cA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4f6c AUSA REDUCTASE
DOMAIN PROTEIN
(Staphylococcus
aureus) 		4 / 5 GLY A2066
GLN A2065
VAL A2285
SER A2068
 None
 1.45A 1zzuA-4f6cA:
undetectable		 1zzuA-4f6cA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AYL_A_FLPA1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4f6c AUSA REDUCTASE
DOMAIN PROTEIN
(Staphylococcus
aureus) 		5 / 12 VAL A2229
TYR A2203
GLY A2133
ALA A2132
LEU A2056
 None
 1.10A 2aylA-4f6cA:
undetectable		 2aylA-4f6cA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AYL_B_FLPB2701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4f6c AUSA REDUCTASE
DOMAIN PROTEIN
(Staphylococcus
aureus) 		5 / 12 VAL A2229
TYR A2203
GLY A2133
ALA A2132
LEU A2056
 None
 1.08A 2aylB-4f6cA:
undetectable		 2aylB-4f6cA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA508_0
(CHORISMATE SYNTHASE)		 4f6c AUSA REDUCTASE
DOMAIN PROTEIN
(Staphylococcus
aureus) 		4 / 5 LEU A2287
ARG A2166
ALA A2286
ILE A2168
 None
 1.12A 2qhfA-4f6cA:
undetectable		 2qhfA-4f6cA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_A_P1ZA1351_1
(PROSTAGLANDIN
REDUCTASE 2)		 4f6c AUSA REDUCTASE
DOMAIN PROTEIN
(Staphylococcus
aureus) 		5 / 10 ILE A2385
PHE A2274
LEU A2311
VAL A2307
LEU A2310
 None
 1.46A 2w98A-4f6cA:
5.9		 2w98A-4f6cA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HZN_G_ACTG225_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4f6c AUSA REDUCTASE
DOMAIN PROTEIN
(Staphylococcus
aureus) 		3 / 3 PRO A2043
LEU A2044
GLN A2289
 None
 0.70A 3hznG-4f6cA:
undetectable
3hznH-4f6cA:
undetectable		 3hznG-4f6cA:
19.48
3hznH-4f6cA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_A_DIFA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4f6c AUSA REDUCTASE
DOMAIN PROTEIN
(Staphylococcus
aureus) 		5 / 11 VAL A2229
TYR A2203
GLY A2133
ALA A2132
LEU A2056
 None
 1.17A 3n8yA-4f6cA:
undetectable		 3n8yA-4f6cA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_B_FLPB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4f6c AUSA REDUCTASE
DOMAIN PROTEIN
(Staphylococcus
aureus) 		5 / 12 VAL A2229
TYR A2203
GLY A2133
ALA A2132
LEU A2056
 None
 1.06A 3n8zB-4f6cA:
undetectable		 3n8zB-4f6cA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NT1_A_NPSA5_1
(PROSTAGLANDIN-ENDOPE
ROXIDE SYNTHASE 2)		 4f6c AUSA REDUCTASE
DOMAIN PROTEIN
(Staphylococcus
aureus) 		5 / 12 VAL A2229
TYR A2203
GLY A2133
ALA A2132
LEU A2056
 None
 1.10A 3nt1A-4f6cA:
undetectable		 3nt1A-4f6cA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1004_1
(HEMOLYTIC LECTIN
CEL-III)		 4f6c AUSA REDUCTASE
DOMAIN PROTEIN
(Staphylococcus
aureus) 		4 / 5 ASP A2278
GLY A2238
TYR A2059
GLU A2062
 None
 1.39A 3w9tA-4f6cA:
undetectable		 3w9tA-4f6cA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1002_1
(HEMOLYTIC LECTIN
CEL-III)		 4f6c AUSA REDUCTASE
DOMAIN PROTEIN
(Staphylococcus
aureus) 		4 / 5 ASP A2278
GLY A2238
TYR A2059
GLU A2062
 None
 1.39A 3w9tC-4f6cA:
undetectable		 3w9tC-4f6cA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD512_1
(HEMOLYTIC LECTIN
CEL-III)		 4f6c AUSA REDUCTASE
DOMAIN PROTEIN
(Staphylococcus
aureus) 		4 / 5 ASP A2278
GLY A2238
TYR A2059
GLU A2062
 None
 1.39A 3w9tD-4f6cA:
undetectable		 3w9tD-4f6cA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG502_1
(HEMOLYTIC LECTIN
CEL-III)		 4f6c AUSA REDUCTASE
DOMAIN PROTEIN
(Staphylococcus
aureus) 		4 / 5 ASP A2278
GLY A2238
TYR A2059
GLU A2062
 None
 1.39A 3w9tG-4f6cA:
undetectable		 3w9tG-4f6cA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_A_IMNA701_1
(CYCLOOXYGENASE-2)		 4f6c AUSA REDUCTASE
DOMAIN PROTEIN
(Staphylococcus
aureus) 		5 / 12 VAL A2229
TYR A2203
GLY A2133
ALA A2132
LEU A2056
 None
 1.06A 4coxA-4f6cA:
undetectable		 4coxA-4f6cA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_B_IMNB701_1
(CYCLOOXYGENASE-2)		 4f6c AUSA REDUCTASE
DOMAIN PROTEIN
(Staphylococcus
aureus) 		5 / 12 VAL A2229
TYR A2203
GLY A2133
ALA A2132
LEU A2056
 None
 1.06A 4coxB-4f6cA:
undetectable		 4coxB-4f6cA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_C_IMNC701_1
(CYCLOOXYGENASE-2)		 4f6c AUSA REDUCTASE
DOMAIN PROTEIN
(Staphylococcus
aureus) 		5 / 12 VAL A2229
TYR A2203
GLY A2133
ALA A2132
LEU A2056
 None
 1.06A 4coxC-4f6cA:
undetectable		 4coxC-4f6cA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_D_IMND701_1
(CYCLOOXYGENASE-2)		 4f6c AUSA REDUCTASE
DOMAIN PROTEIN
(Staphylococcus
aureus) 		5 / 12 VAL A2229
TYR A2203
GLY A2133
ALA A2132
LEU A2056
 None
 1.06A 4coxD-4f6cA:
undetectable		 4coxD-4f6cA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4f6c AUSA REDUCTASE
DOMAIN PROTEIN
(Staphylococcus
aureus) 		5 / 12 VAL A2229
TYR A2203
GLY A2133
ALA A2132
LEU A2056
 None
 1.08A 4rrwA-4f6cA:
undetectable		 4rrwA-4f6cA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4f6c AUSA REDUCTASE
DOMAIN PROTEIN
(Staphylococcus
aureus) 		5 / 12 VAL A2229
TYR A2203
GLY A2133
ALA A2132
LEU A2056
 None
 1.10A 4rrwB-4f6cA:
undetectable		 4rrwB-4f6cA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_C_LURC705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4f6c AUSA REDUCTASE
DOMAIN PROTEIN
(Staphylococcus
aureus) 		5 / 12 VAL A2229
TYR A2203
GLY A2133
ALA A2132
LEU A2056
 None
 1.10A 4rrwC-4f6cA:
undetectable		 4rrwC-4f6cA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRX_A_LURA706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4f6c AUSA REDUCTASE
DOMAIN PROTEIN
(Staphylococcus
aureus) 		5 / 12 VAL A2229
TYR A2203
GLY A2133
ALA A2132
LEU A2056
 None
 1.09A 4rrxA-4f6cA:
undetectable		 4rrxA-4f6cA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4f6c AUSA REDUCTASE
DOMAIN PROTEIN
(Staphylococcus
aureus) 		5 / 12 VAL A2229
TYR A2203
GLY A2133
ALA A2132
LEU A2056
 None
 1.08A 4rrzA-4f6cA:
undetectable		 4rrzA-4f6cA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4f6c AUSA REDUCTASE
DOMAIN PROTEIN
(Staphylococcus
aureus) 		5 / 12 VAL A2229
TYR A2203
GLY A2133
ALA A2132
LEU A2056
 None
 1.10A 4rrzB-4f6cA:
undetectable		 4rrzB-4f6cA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_C_LURC705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4f6c AUSA REDUCTASE
DOMAIN PROTEIN
(Staphylococcus
aureus) 		5 / 12 VAL A2229
TYR A2203
GLY A2133
ALA A2132
LEU A2056
 None
 1.10A 4rrzC-4f6cA:
undetectable		 4rrzC-4f6cA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZGF_A_BEZA210_0
(UNCHARACTERIZED
PROTEIN)		 4f6c AUSA REDUCTASE
DOMAIN PROTEIN
(Staphylococcus
aureus) 		4 / 4 VAL A2214
ALA A2217
ASN A2220
GLN A2161
 None
 1.26A 4zgfA-4f6cA:
undetectable		 4zgfA-4f6cA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DNU_A_BEZA319_0
(SHKAI2IB)		 4f6c AUSA REDUCTASE
DOMAIN PROTEIN
(Staphylococcus
aureus) 		4 / 5 GLN A2161
HIS A2163
ILE A2157
ILE A2129
 None
 1.24A 5dnuA-4f6cA:
3.9		 5dnuA-4f6cA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DNV_A_BEZA304_0
(SHKAI2IB)		 4f6c AUSA REDUCTASE
DOMAIN PROTEIN
(Staphylococcus
aureus) 		4 / 5 GLN A2161
HIS A2163
ILE A2157
ILE A2129
 None
 1.28A 5dnvA-4f6cA:
4.2		 5dnvA-4f6cA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4f6c AUSA REDUCTASE
DOMAIN PROTEIN
(Staphylococcus
aureus) 		5 / 12 VAL A2229
TYR A2203
GLY A2133
ALA A2132
LEU A2056
 None
 1.12A 5ikrA-4f6cA:
undetectable		 5ikrA-4f6cA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4f6c AUSA REDUCTASE
DOMAIN PROTEIN
(Staphylococcus
aureus) 		5 / 12 VAL A2229
TYR A2203
GLY A2133
ALA A2132
LEU A2056
 None
 1.11A 5ikrB-4f6cA:
undetectable		 5ikrB-4f6cA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JVZ_B_FLPB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4f6c AUSA REDUCTASE
DOMAIN PROTEIN
(Staphylococcus
aureus) 		5 / 12 VAL A2229
TYR A2203
GLY A2133
ALA A2132
LEU A2056
 None
 1.11A 5jvzB-4f6cA:
undetectable		 5jvzB-4f6cA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MFX_A_ACTA701_0
(GENOME POLYPROTEIN)		 4f6c AUSA REDUCTASE
DOMAIN PROTEIN
(Staphylococcus
aureus) 		4 / 5 ARG A2228
HIS A2298
ALA A2191
ASP A2192
 None
 1.35A 5mfxA-4f6cA:
undetectable		 5mfxA-4f6cA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		 4f6c AUSA REDUCTASE
DOMAIN PROTEIN
(Staphylococcus
aureus) 		5 / 11 ALA A2217
VAL A2214
VAL A2156
THR A2153
ILE A2168
 None
 1.28A 6h1lB-4f6cA:
undetectable		 6h1lB-4f6cA:
21.69