SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4f6e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_B_ADNB602_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 4f6e SUPEROXIDE DISMUTASE
[MN], MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 12 HIS A  81
ASP A 168
HIS A 172
GLY A  76
PHE A 135
 MN  A 301 (-3.4A)
MN  A 301 (-2.6A)
MN  A 301 (-3.4A)
MLY  A  72 ( 3.5A)
None
 1.03A 1d4fB-4f6eA:
undetectable		 1d4fB-4f6eA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_C_ADNC1503_1
(CLASS B ACID
PHOSPHATASE)		 4f6e SUPEROXIDE DISMUTASE
[MN], MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		4 / 8 LEU A   7
TRP A   9
GLY A  12
ASP A  10
 MLY  A   8 ( 4.0A)
MLY  A   8 ( 4.7A)
None
None
 0.95A 1rmtC-4f6eA:
undetectable		 1rmtC-4f6eA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQN_B_NDRB2001_0
(PROGESTERONE
RECEPTOR)		 4f6e SUPEROXIDE DISMUTASE
[MN], MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 114
LEU A 117
LEU A 120
LEU A 103
LEU A 164
 None
None
MLY  A 119 ( 4.6A)
None
MLY  A 138 ( 4.3A)
 0.99A 1sqnB-4f6eA:
undetectable		 1sqnB-4f6eA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXC_A_P1ZA2001_1
(SERUM ALBUMIN)		 4f6e SUPEROXIDE DISMUTASE
[MN], MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		6 / 12 SER A 131
GLN A 154
LEU A  88
HIS A  81
ILE A  22
ALA A 173
 None
None
None
MN  A 301 (-3.4A)
None
MN  A 301 ( 4.9A)
 1.18A 2bxcA-4f6eA:
undetectable		 2bxcA-4f6eA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_D_2FAD500_1
(ADENOSYLHOMOCYSTEINA
SE)		 4f6e SUPEROXIDE DISMUTASE
[MN], MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 12 HIS A  81
ASP A 168
HIS A 172
GLY A  76
PHE A 135
 MN  A 301 (-3.4A)
MN  A 301 (-2.6A)
MN  A 301 (-3.4A)
MLY  A  72 ( 3.5A)
None
 1.08A 2zj0D-4f6eA:
undetectable		 2zj0D-4f6eA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O7G_A_ASCA303_0
(PROBABLE
TRANSMEMBRANE
ASCORBATE
FERRIREDUCTASE 2)		 4f6e SUPEROXIDE DISMUTASE
[MN], MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		4 / 7 ILE A  18
TYR A 185
PHE A  84
ASN A  87
 None
 1.44A 4o7gA-4f6eA:
undetectable
4o7gB-4f6eA:
undetectable		 4o7gA-4f6eA:
19.26
4o7gB-4f6eA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_A_ADNA501_1
(ADENOSYLHOMOCYSTEINA
SE)		 4f6e SUPEROXIDE DISMUTASE
[MN], MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 12 HIS A  81
ASP A 168
HIS A 172
GLY A  76
PHE A 135
 MN  A 301 (-3.4A)
MN  A 301 (-2.6A)
MN  A 301 (-3.4A)
MLY  A  72 ( 3.5A)
None
 1.07A 5hm8A-4f6eA:
undetectable		 5hm8A-4f6eA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_B_ADNB501_1
(ADENOSYLHOMOCYSTEINA
SE)		 4f6e SUPEROXIDE DISMUTASE
[MN], MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 12 HIS A  81
ASP A 168
HIS A 172
GLY A  76
PHE A 135
 MN  A 301 (-3.4A)
MN  A 301 (-2.6A)
MN  A 301 (-3.4A)
MLY  A  72 ( 3.5A)
None
 1.07A 5hm8B-4f6eA:
undetectable		 5hm8B-4f6eA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_C_ADNC501_1
(ADENOSYLHOMOCYSTEINA
SE)		 4f6e SUPEROXIDE DISMUTASE
[MN], MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 12 HIS A  81
ASP A 168
HIS A 172
GLY A  76
PHE A 135
 MN  A 301 (-3.4A)
MN  A 301 (-2.6A)
MN  A 301 (-3.4A)
MLY  A  72 ( 3.5A)
None
 1.07A 5hm8C-4f6eA:
undetectable		 5hm8C-4f6eA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_D_ADND501_1
(ADENOSYLHOMOCYSTEINA
SE)		 4f6e SUPEROXIDE DISMUTASE
[MN], MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 12 HIS A  81
ASP A 168
HIS A 172
GLY A  76
PHE A 135
 MN  A 301 (-3.4A)
MN  A 301 (-2.6A)
MN  A 301 (-3.4A)
MLY  A  72 ( 3.5A)
None
 1.07A 5hm8D-4f6eA:
undetectable		 5hm8D-4f6eA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_E_ADNE501_1
(ADENOSYLHOMOCYSTEINA
SE)		 4f6e SUPEROXIDE DISMUTASE
[MN], MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 12 HIS A  81
ASP A 168
HIS A 172
GLY A  76
PHE A 135
 MN  A 301 (-3.4A)
MN  A 301 (-2.6A)
MN  A 301 (-3.4A)
MLY  A  72 ( 3.5A)
None
 1.07A 5hm8E-4f6eA:
undetectable		 5hm8E-4f6eA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_F_ADNF501_1
(ADENOSYLHOMOCYSTEINA
SE)		 4f6e SUPEROXIDE DISMUTASE
[MN], MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 12 HIS A  81
ASP A 168
HIS A 172
GLY A  76
PHE A 135
 MN  A 301 (-3.4A)
MN  A 301 (-2.6A)
MN  A 301 (-3.4A)
MLY  A  72 ( 3.5A)
None
 1.07A 5hm8F-4f6eA:
undetectable		 5hm8F-4f6eA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_G_ADNG501_1
(ADENOSYLHOMOCYSTEINA
SE)		 4f6e SUPEROXIDE DISMUTASE
[MN], MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 12 HIS A  81
ASP A 168
HIS A 172
GLY A  76
PHE A 135
 MN  A 301 (-3.4A)
MN  A 301 (-2.6A)
MN  A 301 (-3.4A)
MLY  A  72 ( 3.5A)
None
 1.07A 5hm8G-4f6eA:
undetectable		 5hm8G-4f6eA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_H_ADNH501_1
(ADENOSYLHOMOCYSTEINA
SE)		 4f6e SUPEROXIDE DISMUTASE
[MN], MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 12 HIS A  81
ASP A 168
HIS A 172
GLY A  76
PHE A 135
 MN  A 301 (-3.4A)
MN  A 301 (-2.6A)
MN  A 301 (-3.4A)
MLY  A  72 ( 3.5A)
None
 1.07A 5hm8H-4f6eA:
undetectable		 5hm8H-4f6eA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSU_A_SAMA1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2)		 4f6e SUPEROXIDE DISMUTASE
[MN], MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 132
TRP A 170
TYR A 185
ASN A 122
THR A 121
 None
None
None
MLY  A 187 ( 4.3A)
None
 1.06A 5lsuA-4f6eA:
undetectable		 5lsuA-4f6eA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSU_B_SAMB1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2)		 4f6e SUPEROXIDE DISMUTASE
[MN], MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 132
TRP A 170
TYR A 185
ASN A 122
THR A 121
 None
None
None
MLY  A 187 ( 4.3A)
None
 1.03A 5lsuB-4f6eA:
undetectable		 5lsuB-4f6eA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_A_SAMA306_1
(METHYLTRANSFERASE)		 4f6e SUPEROXIDE DISMUTASE
[MN], MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 103
PHE A 202
ILE A 207
ASN A  87
 None
MLY  A 138 ( 3.9A)
MLY  A 206 ( 4.0A)
None
 1.01A 5n5dA-4f6eA:
undetectable		 5n5dA-4f6eA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB303_1
(BIFUNCTIONAL PROTEIN
FOLD)		 4f6e SUPEROXIDE DISMUTASE
[MN], MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		4 / 5 TYR A 178
GLN A 179
GLY A  12
ILE A  18
 None
MLY  A 181 ( 3.9A)
None
None
 1.15A 6debB-4f6eA:
undetectable		 6debB-4f6eA:
17.91