SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4f6l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_C_NCAC439_0
(ADP-RIBOSYL CYCLASE)		 4f6l AUSA REDUCTASE
DOMAIN PROTEIN
(Staphylococcus
aureus) 		3 / 3 TRP B2377
PHE B2274
TRP B2381
 None
 1.50A 1r15C-4f6lB:
undetectable		 1r15C-4f6lB:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_F_NCAF469_0
(ADP-RIBOSYL CYCLASE)		 4f6l AUSA REDUCTASE
DOMAIN PROTEIN
(Staphylococcus
aureus) 		3 / 3 TRP B2377
PHE B2274
TRP B2381
 None
 1.49A 1r15F-4f6lB:
undetectable		 1r15F-4f6lB:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_G_NCAG479_0
(ADP-RIBOSYL CYCLASE)		 4f6l AUSA REDUCTASE
DOMAIN PROTEIN
(Staphylococcus
aureus) 		3 / 3 TRP B2377
PHE B2274
TRP B2381
 None
 1.49A 1r15G-4f6lB:
undetectable		 1r15G-4f6lB:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_H_NCAH489_0
(ADP-RIBOSYL CYCLASE)		 4f6l AUSA REDUCTASE
DOMAIN PROTEIN
(Staphylococcus
aureus) 		3 / 3 TRP B2377
PHE B2274
TRP B2381
 None
 1.50A 1r15H-4f6lB:
2.0		 1r15H-4f6lB:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U70_A_MTXA187_2
(DIHYDROFOLATE
REDUCTASE)		 4f6l AUSA REDUCTASE
DOMAIN PROTEIN
(Staphylococcus
aureus) 		4 / 4 SER B2171
ILE B2226
VAL B2193
THR B2187
 None
 1.13A 1u70A-4f6lB:
undetectable		 1u70A-4f6lB:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X7P_B_SAMB302_0
(RRNA
METHYLTRANSFERASE)		 4f6l AUSA REDUCTASE
DOMAIN PROTEIN
(Staphylococcus
aureus) 		5 / 10 GLY B2238
ILE B2061
MET B2103
LEU B2091
ALA B2058
 None
 1.06A 1x7pA-4f6lB:
2.5
1x7pB-4f6lB:
2.2		 1x7pA-4f6lB:
19.69
1x7pB-4f6lB:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4f6l AUSA REDUCTASE
DOMAIN PROTEIN
(Staphylococcus
aureus) 		4 / 5 GLY B2066
GLN B2065
VAL B2285
SER B2068
 None
 1.42A 1zzuA-4f6lB:
undetectable		 1zzuA-4f6lB:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXM_A_IMNA2002_1
(SERUM ALBUMIN)		 4f6l AUSA REDUCTASE
DOMAIN PROTEIN
(Staphylococcus
aureus) 		5 / 11 ARG B2239
ILE B2061
LEU B2049
ARG B2243
GLY B2054
 None
 1.27A 2bxmA-4f6lB:
undetectable		 2bxmA-4f6lB:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6O_B_SAMB500_0
(HYPOTHETICAL PROTEIN)		 4f6l AUSA REDUCTASE
DOMAIN PROTEIN
(Staphylococcus
aureus) 		4 / 6 VAL B2150
PHE B2145
PRO B2202
THR B2204
 None
 1.35A 2q6oB-4f6lB:
undetectable		 2q6oB-4f6lB:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA508_0
(CHORISMATE SYNTHASE)		 4f6l AUSA REDUCTASE
DOMAIN PROTEIN
(Staphylococcus
aureus) 		4 / 5 LEU B2287
ARG B2166
ALA B2286
ILE B2168
 None
 1.16A 2qhfA-4f6lB:
undetectable		 2qhfA-4f6lB:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZGF_A_BEZA210_0
(UNCHARACTERIZED
PROTEIN)		 4f6l AUSA REDUCTASE
DOMAIN PROTEIN
(Staphylococcus
aureus) 		4 / 4 VAL B2214
ALA B2217
ASN B2220
GLN B2161
 None
 1.34A 4zgfA-4f6lB:
undetectable		 4zgfA-4f6lB:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_B_REAB602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 4f6l AUSA REDUCTASE
DOMAIN PROTEIN
(Staphylococcus
aureus) 		5 / 9 ILE B2130
GLY B2051
THR B2053
GLN B2289
LEU B2087
 None
 1.35A 5fhzB-4f6lB:
3.8		 5fhzB-4f6lB:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MFX_A_ACTA701_0
(GENOME POLYPROTEIN)		 4f6l AUSA REDUCTASE
DOMAIN PROTEIN
(Staphylococcus
aureus) 		4 / 5 ARG B2228
HIS B2298
ALA B2191
ASP B2192
 None
 1.41A 5mfxA-4f6lB:
undetectable		 5mfxA-4f6lB:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_A_ACTA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4f6l AUSA REDUCTASE
DOMAIN PROTEIN
(Staphylococcus
aureus) 		4 / 5 GLY B2066
GLN B2065
VAL B2285
SER B2068
 None
 1.32A 5vunA-4f6lB:
undetectable		 5vunA-4f6lB:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FTP_B_DM2B501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 4f6l AUSA REDUCTASE
DOMAIN PROTEIN
(Staphylococcus
aureus) 		5 / 9 GLN B2197
LEU B2212
SER B2210
LEU B2199
VAL B2193
 None
 1.30A 6ftpA-4f6lB:
undetectable
6ftpB-4f6lB:
undetectable		 6ftpA-4f6lB:
11.02
6ftpB-4f6lB:
7.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FTP_B_DM2B501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 4f6l AUSA REDUCTASE
DOMAIN PROTEIN
(Staphylococcus
aureus) 		5 / 9 GLN B2197
LEU B2212
SER B2210
PHE B2208
LEU B2199
 None
 1.36A 6ftpA-4f6lB:
undetectable
6ftpB-4f6lB:
undetectable		 6ftpA-4f6lB:
11.02
6ftpB-4f6lB:
7.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		 4f6l AUSA REDUCTASE
DOMAIN PROTEIN
(Staphylococcus
aureus) 		5 / 11 ALA B2217
VAL B2214
VAL B2156
THR B2153
ALA B2165
 None
 1.26A 6h1lB-4f6lB:
undetectable		 6h1lB-4f6lB:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		 4f6l AUSA REDUCTASE
DOMAIN PROTEIN
(Staphylococcus
aureus) 		5 / 11 ALA B2217
VAL B2214
VAL B2156
THR B2153
ILE B2168
 None
 1.24A 6h1lB-4f6lB:
undetectable		 6h1lB-4f6lB:
21.76