SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4f6o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q97_B_ADNB486_1
(SR PROTEIN KINASE)		 4f6o METACASPASE-1
(Saccharomyces
cerevisiae) 		4 / 4 VAL A 388
ALA A 384
LEU A 359
PHE A 385
 None
 1.04A 1q97B-4f6oA:
undetectable		 1q97B-4f6oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_B_DESB459_2
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 4f6o METACASPASE-1
(Saccharomyces
cerevisiae) 		3 / 3 LEU A 284
HIS A 422
ILE A 424
 None
 0.61A 1s9pB-4f6oA:
undetectable		 1s9pB-4f6oA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_A_ZMRA1478_1
(NEURAMINIDASE)		 4f6o METACASPASE-1
(Saccharomyces
cerevisiae) 		4 / 7 ASP A 158
SER A 218
ASN A 144
GLN A 151
 None
 1.09A 2cmlA-4f6oA:
undetectable		 2cmlA-4f6oA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_A_SAMA2001_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 4f6o METACASPASE-1
(Saccharomyces
cerevisiae) 		4 / 7 TYR A 412
GLY A 379
THR A 378
ASP A 274
 None
 1.09A 2g70A-4f6oA:
undetectable		 2g70A-4f6oA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_A_TMQA611_1
(DHFR-TS)		 4f6o METACASPASE-1
(Saccharomyces
cerevisiae) 		5 / 11 ALA A 199
ILE A 141
ILE A 162
LEU A 166
ILE A 177
 None
 1.08A 3clbA-4f6oA:
undetectable		 3clbA-4f6oA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_A_TMQA611_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4f6o METACASPASE-1
(Saccharomyces
cerevisiae) 		5 / 10 ALA A 199
ILE A 141
ILE A 162
LEU A 166
ILE A 177
 None
 1.09A 3hbbA-4f6oA:
undetectable		 3hbbA-4f6oA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_A_MTXA164_2
(DIHYDROFOLATE
REDUCTASE)		 4f6o METACASPASE-1
(Saccharomyces
cerevisiae) 		4 / 4 ILE A 140
PHE A 163
ILE A 177
THR A 181
 None
 1.04A 3ia4A-4f6oA:
undetectable		 3ia4A-4f6oA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQT_A_TESA1000_1
(ANDROGEN RECEPTOR)		 4f6o METACASPASE-1
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 418
LEU A 359
LEU A 272
MET A 389
MET A 432
 None
 1.30A 3zqtA-4f6oA:
undetectable		 3zqtA-4f6oA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQT_A_TESA1000_1
(ANDROGEN RECEPTOR)		 4f6o METACASPASE-1
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 418
LEU A 359
LEU A 272
VAL A 388
MET A 432
 None
 1.40A 3zqtA-4f6oA:
undetectable		 3zqtA-4f6oA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G10_A_ACTA301_0
(GLUTATHIONE
S-TRANSFERASE
HOMOLOG)		 4f6o METACASPASE-1
(Saccharomyces
cerevisiae) 		4 / 6 PRO A 393
ILE A 386
TYR A 170
PHE A 165
 None
 1.21A 4g10A-4f6oA:
undetectable		 4g10A-4f6oA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_B_SAMB301_1
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 4f6o METACASPASE-1
(Saccharomyces
cerevisiae) 		4 / 5 GLN A 417
SER A 360
ASP A 237
ASP A 253
 None
 1.21A 4qtuB-4f6oA:
2.6		 4qtuB-4f6oA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_D_SAMD301_1
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 4f6o METACASPASE-1
(Saccharomyces
cerevisiae) 		4 / 5 GLN A 417
SER A 360
ASP A 237
ASP A 253
 None
 1.21A 4qtuD-4f6oA:
undetectable		 4qtuD-4f6oA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDZ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4f6o METACASPASE-1
(Saccharomyces
cerevisiae) 		4 / 7 ILE A 250
PHE A 273
LEU A 269
MET A 358
 None
 0.64A 4zdzA-4f6oA:
undetectable		 4zdzA-4f6oA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALC_L_TIQL1210_2
(ANTI-TICAGRELOR FAB
72, LIGHT CHAIN)		 4f6o METACASPASE-1
(Saccharomyces
cerevisiae) 		4 / 8 SER A 382
GLY A 379
ILE A 143
GLY A 154
 None
 0.69A 5alcL-4f6oA:
undetectable		 5alcL-4f6oA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESJ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4f6o METACASPASE-1
(Saccharomyces
cerevisiae) 		4 / 8 ILE A 250
PHE A 273
LEU A 269
MET A 358
 None
 0.87A 5esjA-4f6oA:
undetectable		 5esjA-4f6oA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_B_GLYB709_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 4f6o METACASPASE-1
(Saccharomyces
cerevisiae) 		4 / 5 GLY A 134
ASP A 211
ARG A 136
ARG A 135
 None
 1.38A 6dwdB-4f6oA:
undetectable
6dwdD-4f6oA:
undetectable		 6dwdB-4f6oA:
20.36
6dwdD-4f6oA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWJ_B_GLYB710_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 4f6o METACASPASE-1
(Saccharomyces
cerevisiae) 		4 / 5 ARG A 136
ARG A 135
GLY A 134
ASP A 211
 None
 1.31A 6dwjB-4f6oA:
undetectable
6dwjD-4f6oA:
undetectable		 6dwjB-4f6oA:
20.36
6dwjD-4f6oA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKZ_A_SNPA413_0
(AROMATIC
PEROXYGENASE)		 4f6o METACASPASE-1
(Saccharomyces
cerevisiae) 		4 / 7 ASP A 158
GLY A 221
SER A 218
GLY A 219
 None
 0.83A 6ekzA-4f6oA:
undetectable		 6ekzA-4f6oA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA810_0
(GEPHYRIN)		 4f6o METACASPASE-1
(Saccharomyces
cerevisiae) 		3 / 3 LEU A 359
SER A 382
PHE A 385
 None
 0.60A 6fgcA-4f6oA:
4.0		 6fgcA-4f6oA:
21.73