SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4f78'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 4f78 D,D-DIPEPTIDASE/D,D-
CARBOXYPEPTIDASE
(Enterococcus
faecalis) 		3 / 3 ARG A  74
THR A  95
VAL A  99
 SO4  A 303 (-3.1A)
None
SO4  A 303 (-3.6A)
 1.00A 2qakA-4f78A:
undetectable		 2qakA-4f78A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9H_A_NCAA1163_0
(TANKYRASE-2)		 4f78 D,D-DIPEPTIDASE/D,D-
CARBOXYPEPTIDASE
(Enterococcus
faecalis) 		5 / 8 GLY A 172
TYR A 145
LYS A 177
SER A 176
TYR A 173
 None
None
None
None
EDO  A 313 ( 3.9A)
 1.21A 3u9hA-4f78A:
undetectable		 3u9hA-4f78A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9H_B_NCAB1164_0
(TANKYRASE-2)		 4f78 D,D-DIPEPTIDASE/D,D-
CARBOXYPEPTIDASE
(Enterococcus
faecalis) 		5 / 8 GLY A 172
TYR A 145
LYS A 177
SER A 176
TYR A 173
 None
None
None
None
EDO  A 313 ( 3.9A)
 1.22A 3u9hB-4f78A:
undetectable		 3u9hB-4f78A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FR0_A_SAMA401_0
(ARSENIC
METHYLTRANSFERASE)		 4f78 D,D-DIPEPTIDASE/D,D-
CARBOXYPEPTIDASE
(Enterococcus
faecalis) 		5 / 12 PHE A 124
ILE A 122
ASN A  65
VAL A  68
LEU A 115
 None
None
GOL  A 315 (-4.1A)
None
None
 1.09A 4fr0A-4f78A:
undetectable		 4fr0A-4f78A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_B_NCAB1201_0
(TANKYRASE-2)		 4f78 D,D-DIPEPTIDASE/D,D-
CARBOXYPEPTIDASE
(Enterococcus
faecalis) 		5 / 8 GLY A 172
TYR A 145
LYS A 177
SER A 176
TYR A 173
 None
None
None
None
EDO  A 313 ( 3.9A)
 1.13A 4hyfB-4f78A:
undetectable		 4hyfB-4f78A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_C_NCAC1201_0
(TANKYRASE-2)		 4f78 D,D-DIPEPTIDASE/D,D-
CARBOXYPEPTIDASE
(Enterococcus
faecalis) 		5 / 8 GLY A 172
TYR A 145
LYS A 177
SER A 176
TYR A 173
 None
None
None
None
EDO  A 313 ( 3.9A)
 1.08A 4hyfC-4f78A:
undetectable		 4hyfC-4f78A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RV6_A_RPBA1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		 4f78 D,D-DIPEPTIDASE/D,D-
CARBOXYPEPTIDASE
(Enterococcus
faecalis) 		5 / 11 GLY A 172
TYR A 145
LYS A 177
SER A 176
TYR A 173
 None
None
None
None
EDO  A 313 ( 3.9A)
 1.20A 4rv6A-4f78A:
undetectable		 4rv6A-4f78A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RV6_B_RPBB1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		 4f78 D,D-DIPEPTIDASE/D,D-
CARBOXYPEPTIDASE
(Enterococcus
faecalis) 		5 / 11 GLY A 172
TYR A 145
LYS A 177
SER A 176
TYR A 173
 None
None
None
None
EDO  A 313 ( 3.9A)
 1.17A 4rv6B-4f78A:
undetectable		 4rv6B-4f78A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_2
(CYCLIN-DEPENDENT
KINASE 6)		 4f78 D,D-DIPEPTIDASE/D,D-
CARBOXYPEPTIDASE
(Enterococcus
faecalis) 		4 / 4 LYS A 194
HIS A 175
VAL A 171
ASN A 240
 None
 1.06A 5l2iA-4f78A:
undetectable		 5l2iA-4f78A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NVP_A_ACAA18_1
(ENVELOPE
GLYCOPROTEIN,GP41)		 4f78 D,D-DIPEPTIDASE/D,D-
CARBOXYPEPTIDASE
(Enterococcus
faecalis) 		5 / 12 LYS A  22
ASN A  23
GLU A 187
LEU A  19
LEU A 186
 None
EDO  A 309 ( 4.2A)
None
None
None
 1.42A 5nvpA-4f78A:
0.0		 5nvpA-4f78A:
9.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_A_ACTA816_0
(UNCHARACTERIZED
PROTEIN)		 4f78 D,D-DIPEPTIDASE/D,D-
CARBOXYPEPTIDASE
(Enterococcus
faecalis) 		3 / 3 ARG A 140
ARG A 139
ASP A 136
 None
 0.90A 6d8pA-4f78A:
undetectable		 6d8pA-4f78A:
16.69