SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4f7o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_J_TACJ5888_1
(ELONGATION FACTOR
EF-TU)		 4f7o COP9 SIGNALOSOME
COMPLEX SUBUNIT 5
(Homo
sapiens) 		4 / 6 THR A 173
ASP A 171
PRO A 141
VAL A  77
 None
 1.17A 2hdnI-4f7oA:
undetectable
2hdnJ-4f7oA:
undetectable
2hdnL-4f7oA:
undetectable		 2hdnI-4f7oA:
13.38
2hdnJ-4f7oA:
21.04
2hdnL-4f7oA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_E_GCSE710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 4f7o COP9 SIGNALOSOME
COMPLEX SUBUNIT 5
(Homo
sapiens) 		4 / 8 HIS A 138
SER A 148
ILE A 150
HIS A 140
 ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
None
ZN  A 301 (-3.2A)
 1.00A 2xadA-4f7oA:
undetectable		 2xadA-4f7oA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_F_GCSF710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 4f7o COP9 SIGNALOSOME
COMPLEX SUBUNIT 5
(Homo
sapiens) 		4 / 8 HIS A 138
SER A 148
ILE A 150
HIS A 140
 ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
None
ZN  A 301 (-3.2A)
 0.97A 2xadB-4f7oA:
undetectable		 2xadB-4f7oA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_G_GCSG710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 4f7o COP9 SIGNALOSOME
COMPLEX SUBUNIT 5
(Homo
sapiens) 		4 / 8 HIS A 138
SER A 148
ILE A 150
HIS A 140
 ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
None
ZN  A 301 (-3.2A)
 0.98A 2xadC-4f7oA:
undetectable		 2xadC-4f7oA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_H_GCSH710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 4f7o COP9 SIGNALOSOME
COMPLEX SUBUNIT 5
(Homo
sapiens) 		4 / 8 HIS A 138
SER A 148
ILE A 150
HIS A 140
 ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
None
ZN  A 301 (-3.2A)
 0.99A 2xadD-4f7oA:
undetectable		 2xadD-4f7oA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_B_C2FB314_1
(UNCHARACTERIZED
PROTEIN)		 4f7o COP9 SIGNALOSOME
COMPLEX SUBUNIT 5
(Homo
sapiens) 		3 / 3 THR A 103
LYS A 219
GLU A  76
 None
 0.92A 3ijdB-4f7oA:
undetectable		 3ijdB-4f7oA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L35_H_DHIH3_0
(GP41 N-PEPTIDE
HIV ENTRY INHIBITOR
PIE12)		 4f7o COP9 SIGNALOSOME
COMPLEX SUBUNIT 5
(Homo
sapiens) 		3 / 3 LEU A 147
TRP A 146
GLY A 144
 None
 0.78A 3l35A-4f7oA:
undetectable
3l35H-4f7oA:
undetectable		 3l35A-4f7oA:
9.73
3l35H-4f7oA:
5.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L35_K_DHIK3_0
(GP41 N-PEPTIDE
HIV ENTRY INHIBITOR
PIE12)		 4f7o COP9 SIGNALOSOME
COMPLEX SUBUNIT 5
(Homo
sapiens) 		3 / 3 LEU A 147
TRP A 146
GLY A 144
 None
 0.78A 3l35B-4f7oA:
undetectable
3l35K-4f7oA:
undetectable		 3l35B-4f7oA:
9.73
3l35K-4f7oA:
5.06