SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4f7z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_B_CHDB1250_0
(ALCOHOL
DEHYDROGENASE)		 4f7z RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4
(Mus
musculus) 		3 / 3 MET A 298
LEU A 301
SER A 302
 None
 0.67A 1ee2A-4f7zA:
undetectable		 1ee2A-4f7zA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		 4f7z RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4
(Mus
musculus) 		4 / 8 HIS A 519
LEU A 528
ALA A 531
LEU A 532
 None
 0.94A 1hwiB-4f7zA:
undetectable		 1hwiB-4f7zA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		 4f7z RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4
(Mus
musculus) 		4 / 8 HIS A 519
LEU A 528
ALA A 531
LEU A 532
 None
 0.94A 1hwiD-4f7zA:
undetectable		 1hwiD-4f7zA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		 4f7z RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4
(Mus
musculus) 		4 / 8 HIS A 519
LEU A 528
ALA A 531
LEU A 532
 None
 0.94A 1hwiC-4f7zA:
undetectable		 1hwiC-4f7zA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V2X_A_SAMA400_0
(TRNA (GM18)
METHYLTRANSFERASE)		 4f7z RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4
(Mus
musculus) 		5 / 12 LYS A 831
ILE A 832
SER A 754
LEU A 758
ALA A 759
 GOL  A1003 (-2.7A)
None
GOL  A1003 (-4.5A)
None
None
 0.86A 1v2xA-4f7zA:
undetectable		 1v2xA-4f7zA:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_B_DVAB8_0
(GRAMICIDIN D)		 4f7z RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4
(Mus
musculus) 		3 / 3 VAL A 974
VAL A 810
TRP A 808
 None
 0.98A 1w5uA-4f7zA:
undetectable
1w5uB-4f7zA:
undetectable		 1w5uA-4f7zA:
2.20
1w5uB-4f7zA:
2.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_C_DVAC8_0
(GRAMICIDIN D)		 4f7z RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4
(Mus
musculus) 		3 / 3 VAL A 810
TRP A 808
VAL A 974
 None
 0.95A 2izqC-4f7zA:
undetectable
2izqD-4f7zA:
undetectable		 2izqC-4f7zA:
2.20
2izqD-4f7zA:
2.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KUH_A_HLTA150_1
(CALMODULIN)		 4f7z RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4
(Mus
musculus) 		4 / 6 LEU A 428
LEU A 339
GLU A 332
MET A 310
 None
 1.09A 2kuhA-4f7zA:
1.4		 2kuhA-4f7zA:
5.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA801_1
(TRANSPORTER)		 4f7z RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4
(Mus
musculus) 		5 / 12 LEU A 146
ILE A  55
ALA A  43
PHE A  44
LEU A 136
 None
 0.97A 2qb4A-4f7zA:
2.1		 2qb4A-4f7zA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QJU_A_DSMA801_1
(TRANSPORTER)		 4f7z RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4
(Mus
musculus) 		5 / 11 LEU A 146
ILE A  55
ALA A  43
PHE A  44
LEU A 136
 None
 1.00A 2qjuA-4f7zA:
1.1		 2qjuA-4f7zA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		 4f7z RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4
(Mus
musculus) 		4 / 6 ILE A 498
LEU A 500
LEU A 512
ASP A 509
 None
 0.86A 2rlfA-4f7zA:
undetectable
2rlfD-4f7zA:
undetectable		 2rlfA-4f7zA:
4.24
2rlfD-4f7zA:
4.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1501_1
(CYTOCHROME P450 3A4)		 4f7z RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4
(Mus
musculus) 		5 / 10 ILE A 104
PHE A  71
LEU A  64
ILE A 388
GLY A 114
 None
GOL  A1001 (-4.5A)
None
None
GOL  A1001 ( 2.8A)
 1.15A 2v0mA-4f7zA:
undetectable		 2v0mA-4f7zA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WM3_A_NFLA1301_1
(NMRA-LIKE FAMILY
DOMAIN CONTAINING
PROTEIN 1)		 4f7z RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4
(Mus
musculus) 		4 / 6 LEU A 862
THR A 863
ARG A 991
LEU A 988
 None
 0.93A 2wm3A-4f7zA:
undetectable		 2wm3A-4f7zA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_A_CHDA153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4f7z RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4
(Mus
musculus) 		4 / 5 ILE A 975
THR A 746
PHE A 750
PHE A 829
 None
 1.12A 3em0A-4f7zA:
undetectable		 3em0A-4f7zA:
9.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 4f7z RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4
(Mus
musculus) 		6 / 12 ALA A  85
LEU A 135
ARG A 137
ILE A  68
LEU A  70
LEU A  88
 None
 1.22A 3k2hA-4f7zA:
undetectable		 3k2hA-4f7zA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 4f7z RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4
(Mus
musculus) 		5 / 12 ALA A 338
ARG A 429
LEU A 428
ILE A 329
LEU A 314
 None
 1.14A 3k2hB-4f7zA:
undetectable		 3k2hB-4f7zA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_B_D16B520_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4f7z RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4
(Mus
musculus) 		5 / 12 ALA A  85
LEU A 135
ARG A 137
ILE A  68
LEU A  88
 None
 0.95A 3nrrB-4f7zA:
undetectable		 3nrrB-4f7zA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PP1_A_ACTA590_0
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 4f7z RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4
(Mus
musculus) 		4 / 5 GLU A 576
LEU A 574
HIS A 774
GLY A 571
 None
None
GOL  A1006 (-4.7A)
None
 0.90A 3pp1A-4f7zA:
undetectable		 3pp1A-4f7zA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA2_1
(CYTOCHROME P450 2D6)		 4f7z RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4
(Mus
musculus) 		5 / 11 THR A 345
SER A 484
GLU A 931
VAL A 447
THR A 446
 None
 1.39A 3tbgA-4f7zA:
undetectable		 3tbgA-4f7zA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_C_SALC404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 4f7z RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4
(Mus
musculus) 		4 / 7 ALA A 672
PRO A 669
ARG A 667
ALA A 680
 None
 1.10A 3twpC-4f7zA:
undetectable		 3twpC-4f7zA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VKX_A_T3A301_1
(PROLIFERATING CELL
NUCLEAR ANTIGEN)		 4f7z RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4
(Mus
musculus) 		4 / 6 MET A 933
PRO A 524
GLN A 527
PRO A 487
 None
 1.23A 3vkxA-4f7zA:
undetectable		 3vkxA-4f7zA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1476_0
(MJ0495-LIKE PROTEIN)		 4f7z RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4
(Mus
musculus) 		4 / 5 ILE A 779
ALA A 937
HIS A 519
MET A 517
 None
 0.98A 4ac9B-4f7zA:
undetectable
4ac9C-4f7zA:
undetectable		 4ac9B-4f7zA:
20.96
4ac9C-4f7zA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1476_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4f7z RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4
(Mus
musculus) 		4 / 5 ILE A 779
ALA A 937
HIS A 519
MET A 517
 None
 0.97A 4acaB-4f7zA:
undetectable
4acaC-4f7zA:
undetectable		 4acaB-4f7zA:
20.96
4acaC-4f7zA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_C_NCTC501_1
(CYTOCHROME P450 2A6)		 4f7z RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4
(Mus
musculus) 		4 / 5 PHE A 403
PHE A 427
ILE A 379
GLY A 382
 None
 1.03A 4ejjC-4f7zA:
undetectable		 4ejjC-4f7zA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_A_FOLA301_1
(FOLATE RECEPTOR
ALPHA)		 4f7z RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4
(Mus
musculus) 		3 / 3 ASP A 296
TRP A 244
SER A 880
 None
 1.06A 4lrhA-4f7zA:
undetectable		 4lrhA-4f7zA:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_A_MXMA606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4f7z RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4
(Mus
musculus) 		5 / 12 ILE A 438
VAL A 442
LEU A 439
SER A 343
LEU A 342
 None
 0.94A 4m11A-4f7zA:
1.9		 4m11A-4f7zA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_B_MXMB606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4f7z RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4
(Mus
musculus) 		5 / 12 ILE A 438
VAL A 442
LEU A 439
SER A 343
LEU A 342
 None
 0.92A 4m11B-4f7zA:
undetectable		 4m11B-4f7zA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_C_MXMC606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4f7z RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4
(Mus
musculus) 		5 / 12 ILE A 438
VAL A 442
LEU A 439
SER A 343
LEU A 342
 None
 0.93A 4m11C-4f7zA:
undetectable		 4m11C-4f7zA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_D_MXMD606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4f7z RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4
(Mus
musculus) 		5 / 12 ILE A 438
VAL A 442
LEU A 439
SER A 343
LEU A 342
 None
 0.95A 4m11D-4f7zA:
undetectable		 4m11D-4f7zA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_A_0HKA2001_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 4f7z RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4
(Mus
musculus) 		3 / 3 ASN A 803
PHE A 798
TYR A 765
 None
 0.88A 4u15A-4f7zA:
2.2		 4u15A-4f7zA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECM_D_LEUD602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4f7z RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4
(Mus
musculus) 		4 / 7 ALA A 507
THR A 508
VAL A 511
GLU A 501
 None
 0.71A 5ecmD-4f7zA:
1.0		 5ecmD-4f7zA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECN_D_LEUD602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4f7z RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4
(Mus
musculus) 		4 / 8 ALA A 507
THR A 508
VAL A 511
GLU A 501
 None
 0.68A 5ecnD-4f7zA:
undetectable		 5ecnD-4f7zA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECO_D_LEUD602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4f7z RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4
(Mus
musculus) 		4 / 7 ALA A 507
THR A 508
VAL A 511
GLU A 501
 None
 0.75A 5ecoD-4f7zA:
0.9		 5ecoD-4f7zA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_A_ACTA1231_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SU SUBUNIT
PUTATIVE XANTHINE
DEHYDROGENASE YAGT
IRON-SULFUR-BINDING
SUBUNIT)		 4f7z RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4
(Mus
musculus) 		3 / 3 ARG A 785
THR A 715
ASP A 796
 None
 0.72A 5g5gA-4f7zA:
1.4
5g5gB-4f7zA:
undetectable		 5g5gA-4f7zA:
13.36
5g5gB-4f7zA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQB_C_KANC600_1
(BIFUNCTIONAL AAC/APH)		 4f7z RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4
(Mus
musculus) 		5 / 11 GLU A 289
GLU A 286
GLU A 285
GLU A 293
GLU A 183
 None
 1.32A 5iqbC-4f7zA:
1.3		 5iqbC-4f7zA:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_A_EU7A102_0
(MATRIX PROTEIN 2)		 4f7z RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4
(Mus
musculus) 		4 / 6 SER A 673
ALA A 680
SER A 679
ALA A 672
 None
 1.00A 6bocA-4f7zA:
undetectable
6bocB-4f7zA:
undetectable
6bocC-4f7zA:
undetectable
6bocD-4f7zA:
undetectable		 6bocA-4f7zA:
2.11
6bocB-4f7zA:
2.11
6bocC-4f7zA:
2.11
6bocD-4f7zA:
2.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6I_A_8PRA509_1
(ENVELOPE
GLYCOPROTEIN,GP,GP1
ENVELOPE
GLYCOPROTEIN)		 4f7z RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4
(Mus
musculus) 		5 / 12 VAL A 430
LEU A 354
LEU A 439
LEU A 339
LEU A 350
 None
 1.08A 6f6iA-4f7zA:
undetectable
6f6iB-4f7zA:
undetectable		 6f6iA-4f7zA:
7.56
6f6iB-4f7zA:
5.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		 4f7z RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4
(Mus
musculus) 		5 / 11 ALA A 940
VAL A 943
PHE A 770
VAL A 773
LEU A 909
 None
 1.29A 6h1lB-4f7zA:
undetectable		 6h1lB-4f7zA:
18.30