SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4f85'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JZS_A_MRCA1301_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 4f85 GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E
(Streptomyces
lasaliensis) 		5 / 11 GLY A 115
HIS A  86
HIS A  56
SER A 159
ILE A  82
 None
 0.96A 1jzsA-4f85A:
undetectable		 1jzsA-4f85A:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK2_A_ACAA91_1
(TISSUE-TYPE
PLASMINOGEN
ACTIVATOR)		 4f85 GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E
(Streptomyces
lasaliensis) 		4 / 8 VAL A 110
ASP A 166
HIS A 195
LEU A 199
 None
 1.00A 1pk2A-4f85A:
undetectable		 1pk2A-4f85A:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CP4_A_CAMA416_0
(CYTOCHROME P450-CAM)		 4f85 GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E
(Streptomyces
lasaliensis) 		5 / 10 PHE A 198
THR A 167
VAL A 134
GLY A 113
VAL A 191
 None
 1.37A 2cp4A-4f85A:
undetectable		 2cp4A-4f85A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_A_SAMA300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 4f85 GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E
(Streptomyces
lasaliensis) 		5 / 12 GLY A 113
GLY A 115
GLY A 118
THR A 135
LEU A 136
 None
 0.74A 2oxtA-4f85A:
8.9		 2oxtA-4f85A:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_B_SAMB300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 4f85 GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E
(Streptomyces
lasaliensis) 		5 / 12 GLY A 113
GLY A 115
GLY A 117
THR A 135
LEU A 136
 None
 0.82A 2oxtB-4f85A:
8.6		 2oxtB-4f85A:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_C_SAMC300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 4f85 GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E
(Streptomyces
lasaliensis) 		5 / 12 GLY A 113
GLY A 115
GLY A 118
THR A 135
LEU A 136
 None
 0.69A 2oxtC-4f85A:
8.4		 2oxtC-4f85A:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_D_SAMD300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 4f85 GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E
(Streptomyces
lasaliensis) 		6 / 12 ASP A 111
GLY A 113
GLY A 115
GLY A 118
THR A 135
LEU A 136
 None
 0.78A 2oxtD-4f85A:
8.5		 2oxtD-4f85A:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_0
(N,N-DIMETHYLTRANSFER
ASE)		 4f85 GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E
(Streptomyces
lasaliensis) 		5 / 12 GLY A 115
HIS A  58
LEU A 136
SER A 137
MET A 164
 None
 1.36A 3bxoA-4f85A:
17.2		 3bxoA-4f85A:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_0
(N,N-DIMETHYLTRANSFER
ASE)		 4f85 GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E
(Streptomyces
lasaliensis) 		6 / 12 GLY A 115
LEU A 136
SER A 137
MET A 164
SER A 182
TYR A 185
 None
 0.97A 3bxoA-4f85A:
17.2		 3bxoA-4f85A:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_B_SAMB238_0
(N,N-DIMETHYLTRANSFER
ASE)		 4f85 GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E
(Streptomyces
lasaliensis) 		5 / 12 GLY A 115
HIS A  58
LEU A 136
SER A 137
MET A 164
 None
 1.39A 3bxoB-4f85A:
16.3		 3bxoB-4f85A:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_B_SAMB238_0
(N,N-DIMETHYLTRANSFER
ASE)		 4f85 GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E
(Streptomyces
lasaliensis) 		5 / 12 GLY A 115
LEU A 136
MET A 164
SER A 182
TYR A 185
 None
 0.91A 3bxoB-4f85A:
16.3		 3bxoB-4f85A:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_B_SAMB238_0
(N,N-DIMETHYLTRANSFER
ASE)		 4f85 GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E
(Streptomyces
lasaliensis) 		5 / 12 GLY A 115
LEU A 136
SER A 137
MET A 164
TYR A 185
 None
 0.83A 3bxoB-4f85A:
16.3		 3bxoB-4f85A:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELU_A_SAMA4633_0
(METHYLTRANSFERASE)		 4f85 GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E
(Streptomyces
lasaliensis) 		6 / 12 GLY A 113
GLY A 115
GLY A 118
THR A 135
LEU A 136
ASN A 163
 None
 0.76A 3eluA-4f85A:
7.1		 3eluA-4f85A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELW_A_SAMA4633_0
(METHYLTRANSFERASE)		 4f85 GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E
(Streptomyces
lasaliensis) 		6 / 12 GLY A 113
GLY A 115
GLY A 118
THR A 135
LEU A 136
ASN A 163
 None
 0.76A 3elwA-4f85A:
7.8		 3elwA-4f85A:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EMB_A_SAMA4633_0
(METHYLTRANSFERASE)		 4f85 GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E
(Streptomyces
lasaliensis) 		6 / 12 GLY A 113
GLY A 115
GLY A 118
THR A 135
LEU A 136
ASN A 163
 None
 0.74A 3embA-4f85A:
8.5		 3embA-4f85A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_A_SAMA500_0
(PCZA361.24)		 4f85 GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E
(Streptomyces
lasaliensis) 		5 / 12 GLY A 115
LEU A 136
SER A 137
MET A 164
SER A 182
 None
 0.93A 3g2oA-4f85A:
16.7		 3g2oA-4f85A:
29.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_B_TMQB612_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4f85 GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E
(Streptomyces
lasaliensis) 		5 / 9 VAL A 191
ALA A 112
THR A 209
PHE A 230
TYR A 205
 None
 1.49A 3hbbB-4f85A:
undetectable		 3hbbB-4f85A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSK_A_ACTA901_0
(PYRANOSE 2-OXIDASE)		 4f85 GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E
(Streptomyces
lasaliensis) 		4 / 5 SER A 119
GLN A  92
HIS A  57
ASN A 180
 None
 1.38A 3lskA-4f85A:
1.8		 3lskA-4f85A:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSK_B_ACTB901_0
(PYRANOSE 2-OXIDASE)		 4f85 GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E
(Streptomyces
lasaliensis) 		4 / 6 SER A 119
GLN A  92
HIS A  57
ASN A 180
 None
 1.31A 3lskB-4f85A:
2.0		 3lskB-4f85A:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSK_C_ACTC901_0
(PYRANOSE 2-OXIDASE)		 4f85 GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E
(Streptomyces
lasaliensis) 		4 / 5 SER A 119
GLN A  92
HIS A  57
ASN A 180
 None
 1.32A 3lskC-4f85A:
2.0		 3lskC-4f85A:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSK_D_ACTD901_0
(PYRANOSE 2-OXIDASE)		 4f85 GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E
(Streptomyces
lasaliensis) 		4 / 6 SER A 119
GLN A  92
HIS A  57
ASN A 180
 None
 1.31A 3lskD-4f85A:
undetectable		 3lskD-4f85A:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LW5_B_PQNB5002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4f85 GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E
(Streptomyces
lasaliensis) 		5 / 10 ILE A 295
PHE A 198
ARG A 200
ALA A 175
LEU A 199
 None
 1.40A 3lw5B-4f85A:
undetectable		 3lw5B-4f85A:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NW2_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4f85 GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E
(Streptomyces
lasaliensis) 		3 / 3 ARG A 237
ILE A 234
TRP A 212
 None
 1.04A 3nw2B-4f85A:
undetectable		 3nw2B-4f85A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PFG_A_SAMA264_0
(N-METHYLTRANSFERASE)		 4f85 GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E
(Streptomyces
lasaliensis) 		5 / 12 GLY A 115
HIS A  58
LEU A 136
SER A 137
MET A 164
 None
 1.35A 3pfgA-4f85A:
15.9		 3pfgA-4f85A:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PFG_A_SAMA264_0
(N-METHYLTRANSFERASE)		 4f85 GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E
(Streptomyces
lasaliensis) 		5 / 12 GLY A 115
LEU A 136
SER A 137
MET A 164
SER A 182
 None
 1.03A 3pfgA-4f85A:
15.9		 3pfgA-4f85A:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_B_ACTB1358_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 4f85 GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E
(Streptomyces
lasaliensis) 		4 / 7 PRO A 168
ARG A 160
GLY A 133
VAL A 110
 None
 0.97A 4a3uB-4f85A:
undetectable		 4a3uB-4f85A:
22.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4F84_A_SAMA501_0
(GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E)		 4f85 GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E
(Streptomyces
lasaliensis) 		12 / 12 HIS A  57
GLY A 113
GLY A 115
VAL A 134
THR A 135
LEU A 136
GLN A 140
ASN A 163
MET A 164
SER A 182
TYR A 185
VAL A 186
 None
 0.27A 4f84A-4f85A:
42.8		 4f84A-4f85A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_SAMA301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 4f85 GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E
(Streptomyces
lasaliensis) 		5 / 12 GLY A 113
GLY A 115
LEU A 136
SER A 137
VAL A 186
 None
 0.79A 4htfA-4f85A:
17.6		 4htfA-4f85A:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_B_SAMB301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 4f85 GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E
(Streptomyces
lasaliensis) 		5 / 12 GLY A 113
GLY A 115
LEU A 136
SER A 137
VAL A 186
 None
 0.74A 4htfB-4f85A:
17.6		 4htfB-4f85A:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KT0_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 4f85 GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E
(Streptomyces
lasaliensis) 		5 / 11 PHE A 127
GLY A 106
ALA A 175
LEU A 109
LEU A 257
 None
 1.12A 4kt0A-4f85A:
undetectable
4kt0J-4f85A:
undetectable		 4kt0A-4f85A:
18.47
4kt0J-4f85A:
9.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_D_FOLD301_1
(FOLATE RECEPTOR
ALPHA)		 4f85 GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E
(Streptomyces
lasaliensis) 		3 / 3 HIS A  58
TRP A 265
SER A 119
 None
 1.17A 4lrhD-4f85A:
undetectable		 4lrhD-4f85A:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CP4_A_CAMA422_0
(CYTOCHROME P450CAM)		 4f85 GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E
(Streptomyces
lasaliensis) 		5 / 9 PHE A 198
THR A 167
VAL A 134
GLY A 113
VAL A 191
 None
 1.33A 5cp4A-4f85A:
undetectable		 5cp4A-4f85A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_A_RFPA502_2
(RIFAMPIN
MONOOXYGENASE)		 4f85 GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E
(Streptomyces
lasaliensis) 		4 / 4 GLN A 291
VAL A 223
ARG A 242
ARG A 237
 None
 1.16A 6brdA-4f85A:
3.2		 6brdA-4f85A:
14.83