SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4f8a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1Q23_A_FUAA702_1 (CHLORAMPHENICOL ACETYLTRANSFERASE)	4f8a	POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY H MEMBER 1 (Mus musculus)	5 / 12	PHE A 691 SER A 690 VAL A 575 PHE A 620 ALA A 592	None	1.31A	1q23A-4f8aA: undetectable 1q23B-4f8aA: undetectable	1q23A-4f8aA: 22.77 1q23B-4f8aA: 22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1WRK_A_TFPA204_1 (TROPONIN C, SLOW SKELETAL AND CARDIAC MUSCLES)	4f8a	POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY H MEMBER 1 (Mus musculus)	5 / 9	PHE A 620 VAL A 643 LEU A 697 PHE A 582 LEU A 618	None	1.05A	1wrkA-4f8aA: undetectable 1wrkB-4f8aA: undetectable	1wrkA-4f8aA: 23.08 1wrkB-4f8aA: 23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1WRL_B_TFPB203_1 (TROPONIN C, SLOW SKELETAL AND CARDIAC MUSCLES)	4f8a	POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY H MEMBER 1 (Mus musculus)	4 / 6	PHE A 620 VAL A 643 LEU A 697 PHE A 582	None	0.93A	1wrlB-4f8aA: undetectable	1wrlB-4f8aA: 23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1WRL_C_TFPC208_1 (TROPONIN C, SLOW SKELETAL AND CARDIAC MUSCLES)	4f8a	POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY H MEMBER 1 (Mus musculus)	4 / 5	PHE A 620 LEU A 697 PHE A 582 SER A 688	None	1.10A	1wrlC-4f8aA: undetectable	1wrlC-4f8aA: 23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3N8X_B_NIMB1701_1 (PROSTAGLANDIN G/H SYNTHASE 1)	4f8a	POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY H MEMBER 1 (Mus musculus)	5 / 12	LEU A 607 ILE A 629 ALA A 659 SER A 657 LEU A 701	None	1.11A	3n8xB-4f8aA: undetectable	3n8xB-4f8aA: 14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3U9F_R_CLMR221_0 (CHLORAMPHENICOL ACETYLTRANSFERASE)	4f8a	POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY H MEMBER 1 (Mus musculus)	5 / 10	SER A 623 LEU A 626 VAL A 661 PHE A 644 VAL A 621	None	1.38A	3u9fR-4f8aA: undetectable	3u9fR-4f8aA: 22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5IY5_P_CHDP307_0 (CYTOCHROME C OXIDASE SUBUNIT 3 CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL)	4f8a	POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY H MEMBER 1 (Mus musculus)	4 / 5	LEU A 697 PHE A 644 LEU A 695 PHE A 691	None	1.22A	5iy5P-4f8aA: undetectable 5iy5W-4f8aA: undetectable	5iy5P-4f8aA: 19.23 5iy5W-4f8aA: 18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XDX_C_CHDC308_0 (CYTOCHROME C OXIDASE SUBUNIT 3 CYTOCHROME C OXIDASE SUBUNIT VIIA-HEART)	4f8a	POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY H MEMBER 1 (Mus musculus)	4 / 5	LEU A 697 PHE A 644 LEU A 695 PHE A 691	None	1.25A	5xdxC-4f8aA: undetectable 5xdxJ-4f8aA: undetectable	5xdxC-4f8aA: 19.16 5xdxJ-4f8aA: 18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XDX_P_CHDP306_0 (CYTOCHROME C OXIDASE SUBUNIT 3 CYTOCHROME C OXIDASE SUBUNIT VIIA-HEART)	4f8a	POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY H MEMBER 1 (Mus musculus)	4 / 5	LEU A 697 PHE A 644 LEU A 695 PHE A 691	None	1.23A	5xdxP-4f8aA: undetectable 5xdxW-4f8aA: undetectable	5xdxP-4f8aA: 19.16 5xdxW-4f8aA: 18.59

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1Q23_A_FUAA702_1","CHLORAMPHENICOL ACETYLTRANSFERASE;CHLORAMPHENICOL ACETYLTRANSFERASE","4f8a","POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY H MEMBER 1","Mus musculus",5,"PHE A 691;SER A 690;VAL A 575;PHE A 620;ALA A 592","None","1.31A","1q23A-4f8aA:undetectable;1q23B-4f8aA:undetectable","1q23A-4f8aA:22.77;1q23B-4f8aA:22.77"],["1WRK_A_TFPA204_1","TROPONIN C, SLOW SKELETAL AND CARDIAC MUSCLES;TROPONIN C, SLOW SKELETAL AND CARDIAC MUSCLES","4f8a","POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY H MEMBER 1","Mus musculus",5,"PHE A 620;VAL A 643;LEU A 697;PHE A 582;LEU A 618","None","1.05A","1wrkA-4f8aA:undetectable;1wrkB-4f8aA:undetectable","1wrkA-4f8aA:23.08;1wrkB-4f8aA:23.08"],["1WRL_B_TFPB203_1","TROPONIN C, SLOW SKELETAL AND CARDIAC MUSCLES","4f8a","POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY H MEMBER 1","Mus musculus",4,"PHE A 620;VAL A 643;LEU A 697;PHE A 582","None","0.93A","1wrlB-4f8aA:undetectable","1wrlB-4f8aA:23.08"],["1WRL_C_TFPC208_1","TROPONIN C, SLOW SKELETAL AND CARDIAC MUSCLES","4f8a","POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY H MEMBER 1","Mus musculus",4,"PHE A 620;LEU A 697;PHE A 582;SER A 688","None","1.10A","1wrlC-4f8aA:undetectable","1wrlC-4f8aA:23.08"],["3N8X_B_NIMB1701_1","PROSTAGLANDIN G\/H SYNTHASE 1","4f8a","POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY H MEMBER 1","Mus musculus",5,"LEU A 607;ILE A 629;ALA A 659;SER A 657;LEU A 701","None","1.11A","3n8xB-4f8aA:undetectable","3n8xB-4f8aA:14.95"],["3U9F_R_CLMR221_0","CHLORAMPHENICOL ACETYLTRANSFERASE","4f8a","POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY H MEMBER 1","Mus musculus",5,"SER A 623;LEU A 626;VAL A 661;PHE A 644;VAL A 621","None","1.38A","3u9fR-4f8aA:undetectable","3u9fR-4f8aA:22.77"],["5IY5_P_CHDP307_0","CYTOCHROME C OXIDASE SUBUNIT 3;CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL","4f8a","POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY H MEMBER 1","Mus musculus",4,"LEU A 697;PHE A 644;LEU A 695;PHE A 691","None","1.22A","5iy5P-4f8aA:undetectable;5iy5W-4f8aA:undetectable","5iy5P-4f8aA:19.23;5iy5W-4f8aA:18.59"],["5XDX_C_CHDC308_0","CYTOCHROME C OXIDASE SUBUNIT 3;CYTOCHROME C OXIDASE SUBUNIT VIIA-HEART","4f8a","POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY H MEMBER 1","Mus musculus",4,"LEU A 697;PHE A 644;LEU A 695;PHE A 691","None","1.25A","5xdxC-4f8aA:undetectable;5xdxJ-4f8aA:undetectable","5xdxC-4f8aA:19.16;5xdxJ-4f8aA:18.59"],["5XDX_P_CHDP306_0","CYTOCHROME C OXIDASE SUBUNIT 3;CYTOCHROME C OXIDASE SUBUNIT VIIA-HEART","4f8a","POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY H MEMBER 1","Mus musculus",4,"LEU A 697;PHE A 644;LEU A 695;PHE A 691","None","1.23A","5xdxP-4f8aA:undetectable;5xdxW-4f8aA:undetectable","5xdxP-4f8aA:19.16;5xdxW-4f8aA:18.59"]]