SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4f8c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_A_SAMA1001_1
(SAM DEPENDENT
METHYLTRANSFERASE)
4f8c CYCLE INHIBITING
FACTOR

(Yersinia
pseudotuberculos
is)
3 / 3 ASP A 195
ASP A 168
ASP A 245
None
0.73A 2igtA-4f8cA:
undetectable
2igtA-4f8cA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_B_SAMB1002_1
(SAM DEPENDENT
METHYLTRANSFERASE)
4f8c CYCLE INHIBITING
FACTOR

(Yersinia
pseudotuberculos
is)
3 / 3 ASP A 195
ASP A 168
ASP A 245
None
0.73A 2igtB-4f8cA:
undetectable
2igtB-4f8cA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QL8_B_BEZB143_0
(PUTATIVE REDOX
PROTEIN)
4f8c CYCLE INHIBITING
FACTOR

(Yersinia
pseudotuberculos
is)
4 / 6 THR A 182
ALA A 181
ARG A 187
PRO A 185
None
1.32A 2ql8A-4f8cA:
undetectable
2ql8B-4f8cA:
undetectable
2ql8A-4f8cA:
19.25
2ql8B-4f8cA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKY_A_DR7A100_2
(PROTEASE)
4f8c CYCLE INHIBITING
FACTOR

(Yersinia
pseudotuberculos
is)
5 / 9 ARG A 165
ASP A 274
ILE A  72
VAL A 176
ILE A 163
None
1.20A 3ekyB-4f8cA:
undetectable
3ekyB-4f8cA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_A_EPAA1_2
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))
4f8c CYCLE INHIBITING
FACTOR

(Yersinia
pseudotuberculos
is)
5 / 12 THR A 201
ILE A 230
ILE A 235
HIS A 226
TYR A 175
None
EDO  A 302 ( 4.5A)
EDO  A 302 (-4.6A)
EDO  A 302 (-3.9A)
None
1.01A 3gwxA-4f8cA:
undetectable
3gwxA-4f8cA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_A_SAMA405_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)
4f8c CYCLE INHIBITING
FACTOR

(Yersinia
pseudotuberculos
is)
4 / 8 ALA A 214
ILE A 124
ASP A 178
ILE A 163
None
0.74A 4kttB-4f8cA:
undetectable
4kttB-4f8cA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_C_SAMC404_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)
4f8c CYCLE INHIBITING
FACTOR

(Yersinia
pseudotuberculos
is)
4 / 8 ALA A 214
ILE A 124
ASP A 178
ILE A 163
None
0.81A 4kttD-4f8cA:
undetectable
4kttD-4f8cA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWJ_B_GLYB710_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)
4f8c CYCLE INHIBITING
FACTOR

(Yersinia
pseudotuberculos
is)
4 / 5 ARG A 202
GLY A 248
ASN A 249
ASP A 247
None
1.40A 6dwjB-4f8cA:
undetectable
6dwjD-4f8cA:
undetectable
6dwjB-4f8cA:
21.52
6dwjD-4f8cA:
21.52