SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4f8x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_B_ESTB354_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 4f8x ENDO-1,4-BETA-XYLANA
SE
(Penicillium
canescens) 		4 / 8 SER A 169
VAL A 170
LEU A 131
TYR A 179
 None
 1.01A 1fduB-4f8xA:
undetectable		 1fduB-4f8xA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKV_A_EFZA2000_1
(POL POLYPROTEIN)		 4f8x ENDO-1,4-BETA-XYLANA
SE
(Penicillium
canescens) 		5 / 9 LEU A 225
VAL A 235
TYR A 203
GLY A 234
LEU A 221
 None
 1.27A 1ikvA-4f8xA:
1.9		 1ikvA-4f8xA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2002_1
(SERUM ALBUMIN)		 4f8x ENDO-1,4-BETA-XYLANA
SE
(Penicillium
canescens) 		5 / 10 PHE A 180
ALA A 183
ALA A 187
LEU A 191
LEU A 201
 None
 1.19A 2bxeA-4f8xA:
undetectable		 2bxeA-4f8xA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_B_SAMB238_1
(N,N-DIMETHYLTRANSFER
ASE)		 4f8x ENDO-1,4-BETA-XYLANA
SE
(Penicillium
canescens) 		3 / 3 TYR A 203
GLU A 270
ASP A  46
 None
 0.88A 3bxoB-4f8xA:
undetectable		 3bxoB-4f8xA:
24.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_A_ERYA195_0
(REPRESSOR PROTEIN
MPHR(A))		 4f8x ENDO-1,4-BETA-XYLANA
SE
(Penicillium
canescens) 		5 / 12 VAL A 117
LEU A 131
MET A 135
VAL A 170
ILE A 175
 None
 1.17A 3frqA-4f8xA:
undetectable		 3frqA-4f8xA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NMU_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 4f8x ENDO-1,4-BETA-XYLANA
SE
(Penicillium
canescens) 		5 / 11 GLU A 291
TYR A 293
GLY A 244
ILE A 242
GLN A 289
 None
 1.08A 3nmuB-4f8xA:
undetectable
3nmuJ-4f8xA:
undetectable		 3nmuB-4f8xA:
23.00
3nmuJ-4f8xA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R24_A_SAMA302_0
(2'-O-METHYL
TRANSFERASE)		 4f8x ENDO-1,4-BETA-XYLANA
SE
(Penicillium
canescens) 		5 / 12 ASN A 302
GLY A 304
LEU A  32
ASP A  28
PHE A  41
 None
 1.22A 3r24A-4f8xA:
undetectable		 3r24A-4f8xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_B_ADNB401_2
(PUTATIVE ADENOSINE
KINASE)		 4f8x ENDO-1,4-BETA-XYLANA
SE
(Penicillium
canescens) 		4 / 5 LEU A  62
ALA A  99
THR A  43
PHE A  95
 None
 1.33A 3vasB-4f8xA:
2.7		 3vasB-4f8xA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQ8_D_DVAD8_0
(VAL-GRAMICIDIN A)		 4f8x ENDO-1,4-BETA-XYLANA
SE
(Penicillium
canescens) 		3 / 3 TRP A 321
VAL A 312
TRP A 313
 None
 1.13A 3zq8C-4f8xA:
undetectable
3zq8D-4f8xA:
undetectable		 3zq8C-4f8xA:
4.08
3zq8D-4f8xA:
4.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M83_B_ERYB501_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 4f8x ENDO-1,4-BETA-XYLANA
SE
(Penicillium
canescens) 		5 / 11 HIS A 138
TRP A 153
VAL A 156
ALA A 114
SER A 169
 None
 1.47A 4m83B-4f8xA:
undetectable		 4m83B-4f8xA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA306_1
(CHITOSANASE)		 4f8x ENDO-1,4-BETA-XYLANA
SE
(Penicillium
canescens) 		3 / 3 SER A 320
ASP A 317
GLN A 289
 None
 0.86A 4oltA-4f8xA:
undetectable
4oltB-4f8xA:
undetectable		 4oltA-4f8xA:
22.16
4oltB-4f8xA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_D_SAMD301_0
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 4f8x ENDO-1,4-BETA-XYLANA
SE
(Penicillium
canescens) 		5 / 12 GLY A 164
GLY A 162
ILE A 208
SER A 215
ALA A 217
 None
 1.12A 4qtuD-4f8xA:
undetectable		 4qtuD-4f8xA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB304_1
(CHITOSANASE)		 4f8x ENDO-1,4-BETA-XYLANA
SE
(Penicillium
canescens) 		3 / 3 GLN A 289
SER A 320
ASP A 317
 None
 0.81A 4qwpA-4f8xA:
undetectable
4qwpB-4f8xA:
undetectable		 4qwpA-4f8xA:
22.16
4qwpB-4f8xA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_F_CVIF301_1
(REGULATORY PROTEIN
TETR)		 4f8x ENDO-1,4-BETA-XYLANA
SE
(Penicillium
canescens) 		4 / 8 ILE A 242
GLN A 289
TYR A 293
VAL A 322
 None
 1.10A 5vlmF-4f8xA:
undetectable		 5vlmF-4f8xA:
23.37