SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4f9o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4S_A_TPVA201_1
(PROTEIN (HIV-1
PROTEASE))		 4f9o HEXOKINASE-1
(Homo
sapiens) 		5 / 10 ALA A 236
VAL A 386
ILE A 230
GLY A 233
PHE A 264
 None
None
None
BGC  A1001 ( 3.8A)
None
 1.01A 1d4sA-4f9oA:
undetectable		 1d4sA-4f9oA:
8.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_A_9CRA165_1
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 4f9o HEXOKINASE-1
(Homo
sapiens) 		5 / 12 ILE A  92
VAL A 130
VAL A 150
ALA A 201
ILE A 203
 None
 0.86A 1epbA-4f9oA:
undetectable		 1epbA-4f9oA:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_B_9CRB165_1
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 4f9o HEXOKINASE-1
(Homo
sapiens) 		5 / 12 ILE A  92
VAL A 130
VAL A 150
ALA A 201
ILE A 203
 None
 0.92A 1epbB-4f9oA:
undetectable		 1epbB-4f9oA:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRQ_A_STRA501_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 4f9o HEXOKINASE-1
(Homo
sapiens) 		5 / 11 GLU A 343
VAL A 339
ILE A 342
LEU A 328
LEU A 359
 None
 1.15A 1mrqA-4f9oA:
undetectable		 1mrqA-4f9oA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_4
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 4f9o HEXOKINASE-1
(Homo
sapiens) 		4 / 5 VAL A 858
CYH A 672
ALA A 666
CYH A 665
 None
 1.13A 1mz9D-4f9oA:
undetectable		 1mz9D-4f9oA:
4.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PTH_A_SALA710_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 4f9o HEXOKINASE-1
(Homo
sapiens) 		4 / 7 VAL A 410
VAL A 386
ALA A 236
LEU A 228
 None
 0.87A 1pthA-4f9oA:
undetectable		 1pthA-4f9oA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PTH_B_SALB711_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 4f9o HEXOKINASE-1
(Homo
sapiens) 		4 / 7 VAL A 410
VAL A 386
ALA A 236
LEU A 228
 None
 0.88A 1pthB-4f9oA:
undetectable		 1pthB-4f9oA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T88_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 4f9o HEXOKINASE-1
(Homo
sapiens) 		4 / 7 PHE A 427
VAL A 412
GLY A 411
VAL A 440
 None
 0.97A 1t88A-4f9oA:
undetectable		 1t88A-4f9oA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA130_0
(FATTY ACID-BINDING
PROTEIN)		 4f9o HEXOKINASE-1
(Homo
sapiens) 		5 / 12 LEU A 758
ILE A 790
ASP A 815
HIS A 467
ILE A 470
 None
 1.05A 1tw4A-4f9oA:
undetectable		 1tw4A-4f9oA:
9.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_A_SAMA301_0
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 4f9o HEXOKINASE-1
(Homo
sapiens) 		5 / 12 PHE A 515
ALA A 613
THR A 905
VAL A 907
GLU A 524
 None
 1.30A 1vq1A-4f9oA:
undetectable		 1vq1A-4f9oA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4f9o HEXOKINASE-1
(Homo
sapiens) 		3 / 3 MET A 491
ASN A 683
GLN A 739
 None
BGC  A1003 (-3.9A)
BGC  A1003 (-4.4A)
 0.78A 1xoqB-4f9oA:
undetectable		 1xoqB-4f9oA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		 4f9o HEXOKINASE-1
(Homo
sapiens) 		4 / 8 SER A 449
LEU A  93
ASP A  84
ASP A 209
 0NZ  A1002 (-2.8A)
None
0NZ  A1002 (-2.7A)
BGC  A1001 ( 3.0A)
 1.10A 2j2pA-4f9oA:
undetectable
2j2pB-4f9oA:
undetectable		 2j2pA-4f9oA:
13.24
2j2pB-4f9oA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0A_A_GLYA73_0
(NONSTRUCTURAL
PROTEIN 1)		 4f9o HEXOKINASE-1
(Homo
sapiens) 		4 / 5 GLN A 799
ALA A 802
GLN A 805
ILE A 803
 None
 1.39A 2z0aA-4f9oA:
undetectable		 2z0aA-4f9oA:
7.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0A_A_GLYA73_0
(NONSTRUCTURAL
PROTEIN 1)		 4f9o HEXOKINASE-1
(Homo
sapiens) 		4 / 5 GLN A 799
ALA A 802
GLN A 806
ILE A 803
 None
 1.24A 2z0aA-4f9oA:
undetectable		 2z0aA-4f9oA:
7.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A2Q_A_ACAA601_1
(6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE)		 4f9o HEXOKINASE-1
(Homo
sapiens) 		4 / 7 GLY A 135
ALA A 201
VAL A 150
ILE A  92
 None
 0.65A 3a2qA-4f9oA:
undetectable		 3a2qA-4f9oA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIA_B_SAMB206_0
(UPF0217 PROTEIN
MJ1640)		 4f9o HEXOKINASE-1
(Homo
sapiens) 		4 / 5 LEU A 574
GLY A 569
GLU A 572
CYH A 628
 None
 1.08A 3aiaA-4f9oA:
undetectable
3aiaB-4f9oA:
undetectable		 3aiaA-4f9oA:
12.35
3aiaB-4f9oA:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DHID8_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 4f9o HEXOKINASE-1
(Homo
sapiens) 		4 / 4 SER A 415
GLY A 414
GLY A 299
GLY A 233
 0NZ  A1002 (-2.6A)
0NZ  A1002 (-3.1A)
None
BGC  A1001 ( 3.8A)
 0.89A 3bogB-4f9oA:
undetectable
3bogD-4f9oA:
undetectable		 3bogB-4f9oA:
undetectable
3bogD-4f9oA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4f9o HEXOKINASE-1
(Homo
sapiens) 		5 / 9 PHE A 538
SER A 583
LEU A 649
VAL A 651
ILE A 641
 None
 1.39A 3claA-4f9oA:
undetectable		 3claA-4f9oA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHX_B_PXLB313_1
(PYRIDOXAL KINASE)		 4f9o HEXOKINASE-1
(Homo
sapiens) 		4 / 8 SER A 382
VAL A 378
THR A 336
VAL A 306
 None
 1.02A 3fhxB-4f9oA:
undetectable		 3fhxB-4f9oA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IX9_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 4f9o HEXOKINASE-1
(Homo
sapiens) 		5 / 12 ILE A 753
LEU A 474
GLN A 832
VAL A 754
THR A 723
 None
 1.19A 3ix9A-4f9oA:
undetectable		 3ix9A-4f9oA:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_4
(HIV-1 PROTEASE)		 4f9o HEXOKINASE-1
(Homo
sapiens) 		4 / 4 ARG A 638
ASP A 532
GLY A 660
THR A 905
 None
0NZ  A1004 (-2.9A)
None
None
 1.24A 3k4vB-4f9oA:
undetectable		 3k4vB-4f9oA:
8.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK7_A_SAMA770_0
(23S RRNA
METHYLTRANSFERASE)		 4f9o HEXOKINASE-1
(Homo
sapiens) 		5 / 12 THR A 664
GLY A 675
GLY A 859
ILE A 904
SER A 897
 None
None
None
None
0NZ  A1004 (-2.5A)
 1.04A 3nk7A-4f9oA:
undetectable		 3nk7A-4f9oA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QT0_A_486A4_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4f9o HEXOKINASE-1
(Homo
sapiens) 		5 / 12 CYH A 823
SER A 827
ALA A 830
ILE A 757
PHE A 786
 None
 1.04A 3qt0A-4f9oA:
undetectable		 3qt0A-4f9oA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TTR_A_LQZA90_1
(LACTOTRANSFERRIN)		 4f9o HEXOKINASE-1
(Homo
sapiens) 		3 / 3 PRO A 115
THR A 114
LEU A 126
 None
 0.69A 3ttrA-4f9oA:
undetectable		 3ttrA-4f9oA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4f9o HEXOKINASE-1
(Homo
sapiens) 		5 / 11 ALA A 166
PHE A 152
PHE A  90
LEU A 126
VAL A 180
 None
 1.23A 4eilA-4f9oA:
undetectable		 4eilA-4f9oA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_C_FOLC703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4f9o HEXOKINASE-1
(Homo
sapiens) 		5 / 11 ALA A 166
PHE A 152
PHE A  90
LEU A 126
VAL A 180
 None
 1.26A 4eilC-4f9oA:
undetectable		 4eilC-4f9oA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_D_CLQD303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4f9o HEXOKINASE-1
(Homo
sapiens) 		4 / 6 GLY A 681
GLY A 679
GLU A 742
ILE A 745
 BGC  A1003 ( 3.8A)
0NZ  A1004 (-3.2A)
BGC  A1003 (-2.7A)
None
 0.93A 4fglD-4f9oA:
undetectable		 4fglD-4f9oA:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6C_A_STRA501_1
(CYTOCHROME P450
MONOOXYGENASE)		 4f9o HEXOKINASE-1
(Homo
sapiens) 		5 / 11 ALA A 836
ALA A 840
ALA A 839
VAL A 858
LEU A 676
 None
 1.08A 4j6cA-4f9oA:
undetectable		 4j6cA-4f9oA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6C_B_STRB503_1
(CYTOCHROME P450
MONOOXYGENASE)		 4f9o HEXOKINASE-1
(Homo
sapiens) 		5 / 10 ALA A 836
ALA A 840
ALA A 839
VAL A 858
LEU A 676
 None
 1.08A 4j6cB-4f9oA:
undetectable		 4j6cB-4f9oA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6D_A_TESA503_1
(CYTOCHROME P450
MONOOXYGENASE)		 4f9o HEXOKINASE-1
(Homo
sapiens) 		5 / 12 ALA A 836
ALA A 840
ALA A 839
VAL A 858
LEU A 676
 None
 1.04A 4j6dA-4f9oA:
undetectable		 4j6dA-4f9oA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6D_B_TESB502_1
(CYTOCHROME P450
MONOOXYGENASE)		 4f9o HEXOKINASE-1
(Homo
sapiens) 		5 / 12 ALA A 836
ALA A 840
ALA A 839
VAL A 858
LEU A 676
 None
 1.07A 4j6dB-4f9oA:
undetectable		 4j6dB-4f9oA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JBT_A_ASDA501_1
(CYTOCHROME P450
MONOOXYGENASE)		 4f9o HEXOKINASE-1
(Homo
sapiens) 		5 / 12 ALA A 836
ALA A 840
ALA A 839
VAL A 858
LEU A 676
 None
 1.06A 4jbtA-4f9oA:
undetectable		 4jbtA-4f9oA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JBT_B_ASDB502_1
(CYTOCHROME P450
MONOOXYGENASE)		 4f9o HEXOKINASE-1
(Homo
sapiens) 		5 / 11 ALA A 836
ALA A 840
ALA A 839
VAL A 858
LEU A 676
 None
 1.07A 4jbtB-4f9oA:
undetectable		 4jbtB-4f9oA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JUO_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA)		 4f9o HEXOKINASE-1
(Homo
sapiens) 		3 / 4 SER A 733
GLY A 710
GLU A 494
 None
 0.60A 4juoA-4f9oA:
2.7
4juoC-4f9oA:
undetectable		 4juoA-4f9oA:
19.78
4juoC-4f9oA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R21_B_STRB601_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 4f9o HEXOKINASE-1
(Homo
sapiens) 		5 / 9 VAL A 659
GLY A 900
ALA A 902
THR A 905
VAL A 655
 None
 1.05A 4r21B-4f9oA:
undetectable		 4r21B-4f9oA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XT8_A_TMQA302_1
(RV2671)		 4f9o HEXOKINASE-1
(Homo
sapiens) 		5 / 12 ILE A 229
GLY A 414
ASP A 209
GLU A 294
THR A 210
 BGC  A1001 (-4.2A)
0NZ  A1002 (-3.1A)
BGC  A1001 ( 3.0A)
BGC  A1001 (-2.6A)
BGC  A1001 (-4.0A)
 1.31A 4xt8A-4f9oA:
undetectable		 4xt8A-4f9oA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_A_DB8A800_2
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 4f9o HEXOKINASE-1
(Homo
sapiens) 		4 / 4 VAL A 841
ILE A 705
ASN A 683
VAL A 509
 None
None
BGC  A1003 (-3.9A)
None
 1.24A 5ajqA-4f9oA:
undetectable		 5ajqA-4f9oA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBS_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 4f9o HEXOKINASE-1
(Homo
sapiens) 		5 / 12 VAL A 678
LEU A 864
ILE A 721
ILE A 745
LEU A 484
 None
 1.03A 5hbsA-4f9oA:
undetectable		 5hbsA-4f9oA:
9.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_B_6V8B304_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		 4f9o HEXOKINASE-1
(Homo
sapiens) 		6 / 12 THR A 153
THR A 457
ALA A 460
SER A 449
GLY A 450
THR A 216
 0NZ  A1002 ( 4.6A)
None
None
0NZ  A1002 (-2.8A)
None
None
 1.49A 5lf7V-4f9oA:
undetectable
5lf7b-4f9oA:
undetectable		 5lf7V-4f9oA:
13.99
5lf7b-4f9oA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_B_SAMB303_0
(METHYLTRANSFERASE)		 4f9o HEXOKINASE-1
(Homo
sapiens) 		5 / 12 ALA A 183
VAL A 180
ILE A 193
ALA A 201
PHE A 127
 None
 1.14A 5n5dB-4f9oA:
undetectable		 5n5dB-4f9oA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_H_RITH602_1
(CYTOCHROME P450 3A5)		 4f9o HEXOKINASE-1
(Homo
sapiens) 		5 / 12 LEU A 397
ILE A 393
ALA A 236
THR A 210
GLY A 218
 None
None
None
BGC  A1001 (-4.0A)
None
 1.07A 5veuH-4f9oA:
undetectable		 5veuH-4f9oA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BZO_C_FI8C1201_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 4f9o HEXOKINASE-1
(Homo
sapiens) 		5 / 12 THR A 821
VAL A 822
VAL A 825
SER A 816
GLU A 252
 None
 1.29A 6bzoC-4f9oA:
undetectable		 6bzoC-4f9oA:
23.00