SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4f9u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GXS_A_BEZA601_0
(P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
A
P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
B)		 4f9u CG32412
(Drosophila
melanogaster) 		4 / 7 GLY A  58
ASP A 168
SER A  56
ALA A  95
 None
 0.90A 1gxsA-4f9uA:
3.1
1gxsB-4f9uA:
undetectable		 1gxsA-4f9uA:
23.19
1gxsB-4f9uA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q0Y_H_MOIH401_1
(FAB 9B1, HEAVY CHAIN
FAB 9B1, LIGHT CHAIN)		 4f9u CG32412
(Drosophila
melanogaster) 		4 / 7 GLU A 171
TRP A 296
LEU A 219
TRP A 176
 ZN  A 401 ( 2.1A)
ZN  A 401 (-4.8A)
None
PBD  A 402 (-4.0A)
 1.31A 1q0yH-4f9uA:
undetectable
1q0yL-4f9uA:
undetectable		 1q0yH-4f9uA:
20.52
1q0yL-4f9uA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_C_TFPC208_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4f9u CG32412
(Drosophila
melanogaster) 		4 / 5 PHE A 318
LEU A 164
PHE A 314
SER A 132
 None
 1.17A 1wrlC-4f9uA:
undetectable		 1wrlC-4f9uA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XPQ_A_SPMA924_1
(FMS1 PROTEIN)		 4f9u CG32412
(Drosophila
melanogaster) 		5 / 11 ASP A  80
ASN A  96
LEU A 216
PHE A 277
LEU A 214
 None
 1.30A 1xpqA-4f9uA:
1.1		 1xpqA-4f9uA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XPQ_C_SPMC921_1
(FMS1 PROTEIN)		 4f9u CG32412
(Drosophila
melanogaster) 		5 / 11 ASP A  80
ASN A  96
LEU A 216
PHE A 277
LEU A 214
 None
 1.30A 1xpqC-4f9uA:
0.0		 1xpqC-4f9uA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HKK_A_ALEA300_1
(CARBONIC ANHYDRASE 2)		 4f9u CG32412
(Drosophila
melanogaster) 		4 / 6 ASN A 141
HIS A  40
ASN A 315
ILE A 220
 None
 1.20A 2hkkA-4f9uA:
undetectable		 2hkkA-4f9uA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_1
(O-METHYLTRANSFERASE)		 4f9u CG32412
(Drosophila
melanogaster) 		3 / 3 ASP A 116
PHE A  94
SER A 185
 None
 0.76A 3i5uB-4f9uA:
undetectable		 3i5uB-4f9uA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 4f9u CG32412
(Drosophila
melanogaster) 		5 / 12 ILE A 220
GLY A 221
PHE A 314
ALA A 133
VAL A 134
 None
 0.94A 3jb2A-4f9uA:
undetectable		 3jb2A-4f9uA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 4f9u CG32412
(Drosophila
melanogaster) 		5 / 12 ILE A 220
GLY A 221
PHE A 314
ALA A 133
VAL A 134
 None
 0.95A 3jb3A-4f9uA:
undetectable		 3jb3A-4f9uA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_A_CGEA501_1
(CYTOCHROME P450 2B4)		 4f9u CG32412
(Drosophila
melanogaster) 		5 / 10 VAL A 322
PHE A 318
ALA A 112
ILE A 211
VAL A 213
 None
 1.04A 3me6A-4f9uA:
undetectable		 3me6A-4f9uA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MJR_D_AC2D601_1
(DEOXYCYTIDINE KINASE)		 4f9u CG32412
(Drosophila
melanogaster) 		4 / 8 GLU A 255
ARG A 316
ARG A 312
ASP A  36
 None
 0.85A 3mjrD-4f9uA:
1.7		 3mjrD-4f9uA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N2O_C_AG2C1002_1
(BIOSYNTHETIC
ARGININE
DECARBOXYLASE)		 4f9u CG32412
(Drosophila
melanogaster) 		4 / 8 ASP A 131
LEU A 219
ASP A 272
ASP A 273
 ZN  A 401 ( 2.3A)
None
PBD  A 402 ( 4.3A)
None
 1.22A 3n2oC-4f9uA:
undetectable
3n2oD-4f9uA:
undetectable		 3n2oC-4f9uA:
18.41
3n2oD-4f9uA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OI8_A_ADNA2_1
(UNCHARACTERIZED
PROTEIN)		 4f9u CG32412
(Drosophila
melanogaster) 		4 / 6 HIS A 297
PRO A 293
LEU A 219
ASP A 272
 ZN  A 401 ( 3.1A)
None
None
PBD  A 402 ( 4.3A)
 1.16A 3oi8A-4f9uA:
undetectable		 3oi8A-4f9uA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_A_SAMA401_1
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 4f9u CG32412
(Drosophila
melanogaster) 		4 / 5 SER A 181
THR A 177
GLU A 171
ASP A 301
 None
None
ZN  A 401 ( 2.1A)
None
 1.37A 3tm4A-4f9uA:
undetectable		 3tm4A-4f9uA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_1
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 4f9u CG32412
(Drosophila
melanogaster) 		4 / 5 SER A 181
THR A 177
GLU A 171
ASP A 301
 None
None
ZN  A 401 ( 2.1A)
None
 1.37A 3tm4B-4f9uA:
undetectable		 3tm4B-4f9uA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3XIM_C_SORC397_0
(D-XYLOSE ISOMERASE)		 4f9u CG32412
(Drosophila
melanogaster) 		5 / 12 GLU A 170
HIS A 114
ASP A 273
ASP A 131
ASP A 272
 PBD  A 402 (-3.4A)
None
None
ZN  A 401 ( 2.3A)
PBD  A 402 ( 4.3A)
 1.50A 3ximC-4f9uA:
undetectable		 3ximC-4f9uA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_C_PXLC300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4f9u CG32412
(Drosophila
melanogaster) 		4 / 8 ASP A 168
GLY A 169
VAL A  86
HIS A  59
 None
 0.77A 4c5nC-4f9uA:
undetectable		 4c5nC-4f9uA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PQA_A_X8ZA401_1
(SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE)		 4f9u CG32412
(Drosophila
melanogaster) 		5 / 11 HIS A 114
ASP A 131
GLU A 170
GLU A 171
HIS A 297
 None
ZN  A 401 ( 2.3A)
PBD  A 402 (-3.4A)
ZN  A 401 ( 2.1A)
ZN  A 401 ( 3.1A)
 0.34A 4pqaA-4f9uA:
21.9		 4pqaA-4f9uA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEP_A_VDYA201_1
(CDL2.3B)		 4f9u CG32412
(Drosophila
melanogaster) 		5 / 12 LEU A 278
LEU A 287
LEU A 217
THR A 234
LEU A 109
 GOL  A 405 (-4.8A)
None
None
GOL  A 405 ( 4.1A)
None
 1.09A 5iepA-4f9uA:
undetectable		 5iepA-4f9uA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIM_A_SORA397_0
(D-XYLOSE ISOMERASE)		 4f9u CG32412
(Drosophila
melanogaster) 		5 / 12 GLU A 170
HIS A 114
ASP A 273
ASP A 131
ASP A 272
 PBD  A 402 (-3.4A)
None
None
ZN  A 401 ( 2.3A)
PBD  A 402 ( 4.3A)
 1.50A 5ximA-4f9uA:
undetectable		 5ximA-4f9uA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIM_C_SORC397_0
(D-XYLOSE ISOMERASE)		 4f9u CG32412
(Drosophila
melanogaster) 		5 / 12 GLU A 170
HIS A 114
ASP A 273
ASP A 131
ASP A 272
 PBD  A 402 (-3.4A)
None
None
ZN  A 401 ( 2.3A)
PBD  A 402 ( 4.3A)
 1.49A 5ximC-4f9uA:
undetectable		 5ximC-4f9uA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIM_D_SORD397_0
(D-XYLOSE ISOMERASE)		 4f9u CG32412
(Drosophila
melanogaster) 		5 / 12 GLU A 170
HIS A 114
ASP A 273
ASP A 131
ASP A 272
 PBD  A 402 (-3.4A)
None
None
ZN  A 401 ( 2.3A)
PBD  A 402 ( 4.3A)
 1.49A 5ximD-4f9uA:
undetectable		 5ximD-4f9uA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0K_B_DAHB98_0
(MELC
TYROSINASE)		 4f9u CG32412
(Drosophila
melanogaster) 		5 / 11 HIS A 114
HIS A 297
VAL A 295
SER A 132
PRO A 299
 None
ZN  A 401 ( 3.1A)
None
None
None
 1.49A 5z0kA-4f9uA:
undetectable
5z0kB-4f9uA:
undetectable		 5z0kA-4f9uA:
14.47
5z0kB-4f9uA:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_B_HISB402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 4f9u CG32412
(Drosophila
melanogaster) 		5 / 9 VAL A 127
VAL A 295
LEU A  49
GLY A 221
LEU A 306
 None
 1.34A 6czmA-4f9uA:
undetectable
6czmB-4f9uA:
undetectable		 6czmA-4f9uA:
23.58
6czmB-4f9uA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_F_HISF402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 4f9u CG32412
(Drosophila
melanogaster) 		5 / 10 VAL A 127
VAL A 295
LEU A  49
GLY A 221
LEU A 306
 None
 1.33A 6czmE-4f9uA:
undetectable
6czmF-4f9uA:
undetectable		 6czmE-4f9uA:
23.58
6czmF-4f9uA:
23.58