SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4f9z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D55_C_DVAC8_0
(ACTINOMYCIN D)		 4f9z ENDOPLASMIC
RETICULUM RESIDENT
PROTEIN 27
(Homo
sapiens) 		3 / 3 PRO D 236
THR D 237
PRO D 220
 None
 0.84A 2d55C-4f9zD:
undetectable		 2d55C-4f9zD:
7.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KUH_A_HLTA150_1
(CALMODULIN)		 4f9z ENDOPLASMIC
RETICULUM RESIDENT
PROTEIN 27
(Homo
sapiens) 		4 / 6 MET D 168
LEU D 197
MET D 179
GLU D 176
 None
 1.16A 2kuhA-4f9zD:
undetectable		 2kuhA-4f9zD:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_B_SAMB1000_1
(UNCHARACTERIZED
PROTEIN MJ0100)		 4f9z ENDOPLASMIC
RETICULUM RESIDENT
PROTEIN 27
(Homo
sapiens) 		3 / 3 ASN D 205
ASN D 169
GLU D 216
 None
 0.88A 3kpdC-4f9zD:
undetectable		 3kpdC-4f9zD:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_C_SAMC1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 4f9z ENDOPLASMIC
RETICULUM RESIDENT
PROTEIN 27
(Homo
sapiens) 		3 / 3 ASN D 205
ASN D 169
GLU D 216
 None
 0.81A 3kpdB-4f9zD:
undetectable		 3kpdB-4f9zD:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BB2_B_STRB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 4f9z ENDOPLASMIC
RETICULUM RESIDENT
PROTEIN 27
(Homo
sapiens) 		5 / 11 ALA D 129
SER D 133
PHE D  64
ILE D 106
HIS D  76
 None
 1.45A 4bb2A-4f9zD:
undetectable
4bb2B-4f9zD:
undetectable		 4bb2A-4f9zD:
23.01
4bb2B-4f9zD:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G5J_A_0WMA1102_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4f9z ENDOPLASMIC
RETICULUM RESIDENT
PROTEIN 27
(Homo
sapiens) 		4 / 7 TYR D 225
HIS D 163
ILE D 196
TYR D 147
 None
 1.12A 4g5jA-4f9zD:
undetectable		 4g5jA-4f9zD:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GRQ_C_AVLC203_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 4f9z ENDOPLASMIC
RETICULUM RESIDENT
PROTEIN 27
(Homo
sapiens) 		4 / 7 PHE D 212
TYR D 225
TYR D 147
PHE D 156
 None
 1.16A 4grqA-4f9zD:
undetectable
4grqC-4f9zD:
undetectable		 4grqA-4f9zD:
18.75
4grqC-4f9zD:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)		 4f9z ENDOPLASMIC
RETICULUM RESIDENT
PROTEIN 27
(Homo
sapiens) 		5 / 12 VAL D 208
SER D 210
PHE D 212
VAL D 240
LEU D 166
 None
 1.16A 5ergB-4f9zD:
undetectable		 5ergB-4f9zD:
19.79