SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4fab'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2M2P_B_DHIB24_0 (INSULIN B CHAIN)	4fab	IGG2A-KAPPA 4-4-20 FAB (HEAVY CHAIN) (Mus musculus)	3 / 3	TYR H 180 GLY H 149 PHE H 151	None	0.71A	2m2pB-4fabH: undetectable	2m2pB-4fabH: 9.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5LAK_I_BEZI1_0 (3CL PROTEASE BEZ-TYR-TYR-ASN-ECC PEPTIDE INHIBITOR)	4fab	IGG2A-KAPPA 4-4-20 FAB (HEAVY CHAIN) (Mus musculus)	3 / 3	SER H 63 TYR H 62 TYR H 61	None	0.66A	5lakA-4fabH: undetectable 5lakI-4fabH: undetectable	5lakA-4fabH: 20.25 5lakI-4fabH: 2.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5LAK_J_BEZJ1_0 (3CL PROTEASE BEZ-TYR-TYR-ASN-ECC PEPTIDE INHIBITOR)	4fab	IGG2A-KAPPA 4-4-20 FAB (HEAVY CHAIN) (Mus musculus)	3 / 3	SER H 63 TYR H 62 TYR H 61	None	0.59A	5lakC-4fabH: undetectable 5lakJ-4fabH: undetectable	5lakC-4fabH: 20.25 5lakJ-4fabH: 2.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6AUU_A_ACTA804_0 (NITRIC OXIDE SYNTHASE, BRAIN)	4fab	IGG2A-KAPPA 4-4-20 FAB (HEAVY CHAIN) (Mus musculus)	3 / 3	GLN H 196 TRP H 193 VAL H 188	None	1.10A	6auuA-4fabH: undetectable	6auuA-4fabH: 18.01

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2M2P_B_DHIB24_0","INSULIN B CHAIN","4fab","IGG2A-KAPPA 4-4-20 FAB (HEAVY CHAIN)","Mus musculus",3,"TYR H 180;GLY H 149;PHE H 151","None","0.71A","2m2pB-4fabH:undetectable","2m2pB-4fabH:9.62"],["5LAK_I_BEZI1_0","3CL PROTEASE;BEZ-TYR-TYR-ASN-ECC PEPTIDE INHIBITOR","4fab","IGG2A-KAPPA 4-4-20 FAB (HEAVY CHAIN)","Mus musculus",3,"SER H  63;TYR H  62;TYR H  61","None","0.66A","5lakA-4fabH:undetectable;5lakI-4fabH:undetectable","5lakA-4fabH:20.25;5lakI-4fabH:2.27"],["5LAK_J_BEZJ1_0","3CL PROTEASE;BEZ-TYR-TYR-ASN-ECC PEPTIDE INHIBITOR","4fab","IGG2A-KAPPA 4-4-20 FAB (HEAVY CHAIN)","Mus musculus",3,"SER H  63;TYR H  62;TYR H  61","None","0.59A","5lakC-4fabH:undetectable;5lakJ-4fabH:undetectable","5lakC-4fabH:20.25;5lakJ-4fabH:2.27"],["6AUU_A_ACTA804_0","NITRIC OXIDE SYNTHASE, BRAIN","4fab","IGG2A-KAPPA 4-4-20 FAB (HEAVY CHAIN)","Mus musculus",3,"GLN H 196;TRP H 193;VAL H 188","None","1.10A","6auuA-4fabH:undetectable","6auuA-4fabH:18.01"]]